Frequency of CCR5Δ32 allele in healthy Bosniak population.

  • Grażyna Adler The Department of Gerontobiology, Pomeranian Medical University, ul. Żołnierska 48, 71-210 Szczecin, Poland
  • Amina Valjevac Laboratory for Molecular Medicine, Center for Genetics, Medical Faculty, University Sarajevo, Cekalusa 90, 71 000 Sarajevo, Bosnia and Herzegovina
  • Karolina Skonieczna-Żydecka The Department of Gerontobiology, Pomeranian Medical University, ul. Żołnierska 48, 71-210 Szczecin, Poland
  • Mirela Mackic-Djurovic Laboratory for Molecular Medicine, Center for Genetics, Medical Faculty, University Sarajevo, Cekalusa 90, 71 000 Sarajevo, Bosnia and Herzegovina
  • Miłosz Parczewski Department of Infectious Diseases and Hepatology, Pomeranian Medical University, ul. Arkońska 4, 71-455 Szczecin, Poland
  • Anna Urbańska Department of Infectious Diseases and Hepatology, Pomeranian Medical University, ul. Arkońska 4, 71-455 Szczecin, Poland
  • Nermin Nusret Salkic Department of Gastroenterology and Hepatology, University Clinical Center Tuzla, Trnovac bb, 75 000 Tuzla, Bosnia and Herzegovina
Keywords: cytokine receptor, del32 variant, genetic epidemiology, HIV susceptibility

Abstract

Recent evidence has demonstrated the role of CCR5Δ32 in a variety of human diseases: from infectious and inflammatory diseases to cancer. Several studies have confirmed that genetic variants in chemokine receptor CCR5 gene are correlated with susceptibility and resistance to HIV infection. A 32-nucleotide deletion within the CCR5 reading frame is associated with decreased susceptibility to HIV acquisition and a slower progression to AIDS. Mean frequency of CCR5Δ32 allele in Europe is approximately 10%. The highest allele frequency is observed among Nordic populations (about 12%) and lower in the regions of Southeast Mediterranean (about 5%). Although the frequency of CCR5Δ32 was determined in numerous European populations, there is a lack of studies on this variant in the Bosnia and Hercegovina population. Therefore, the aim of our study was to assess the frequency of CCR5Δ32 allele in the cohort of Bosniaks and compare the results with European reports. CCR5Δ32 was detected by sequence-specific PCR in a sample of 100 healthy subjects from Bosnia and Herzegovina (DNA collected 2011-2013).  Mean age of the cohort being 58.8 (±10.7) years, with 82% of women. We identified 17 heterozygotes and one mutant homozygote in study group, with mean ∆32 allele frequency of 9.5%. CCR5∆32 allele frequency among Bosniaks is comparable to that found in Caucasian populations and follows the pattern of the north-southern gradient observed for Europe. Further studies on larger cohorts with adequate female-to-male ratio are necessary.

 

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Author Biography

Grażyna Adler, The Department of Gerontobiology, Pomeranian Medical University, ul. Żołnierska 48, 71-210 Szczecin, Poland

The present study was performed in accordance with the ethical standards and the Declaration of Helsinki. Written informed consent was obtained from all participants.

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Published
2014-08-28
How to Cite
1.
Adler G, Valjevac A, Skonieczna-Żydecka K, Mackic-Djurovic M, Parczewski M, Urbańska A, Salkic NN. Frequency of CCR5Δ32 allele in healthy Bosniak population. Bosn J of Basic Med Sci [Internet]. 2014Aug.28 [cited 2019Dec.10];14(3):150-4. Available from: http://www.bjbms.org/ojs/index.php/bjbms/article/view/150
Section
Molecular Biology