Influence of Rho Kinase Inhibitor Fasudil on Late Endothelial Progenitor Cells in Peripheral Blood of COPD Patients with Pulmonary Artery Hypertension

  • Pei Liu Intense Care Unit, Taihe Hospital of Hubei Medical University
  • Hongmei Zhang Department of Respiratoy Diseases, Taihe Hospital of Hubei Medical University
  • Yijun Tang Department of Respiratoy Diseases, Taihe Hospital of Hubei Medical University
  • Chunfeng Sheng Intense Care Unit, Taihe Hospital of Hubei Medical University
  • Jianxin Liu Department of Ultrasound Imaging, Taihe Hospital of Hubei Medical University Shiyan
  • Yanjun Zeng Beijing University of Technology
Keywords: Rho Kinase Inhibitor Fasudil, chronic obstructive pulmonary diseases, pulmonary artery hypertensio, endothelial progenitor cells, number and function of the late endothelial progenitor cells

Abstract

The objective of our work was to investigate the influence of Fasudil, a Rho inhibitor on the number and function of the late endothelial progenitor cells in peripheral blood of chronic obstructive pulmonary diseases (COPD) patients with pulmonary artery hypertension. Eighty COPD patients with pulmonary artery hypertension were selected and divided into two groups: the treatment group and the control group, which had 40 patients respectively. The control group received routine treatment, including oxygen uptake, anti-infection and phlegm dissolving. The treatment group received the Fasudil in addition to the routine treatment. The changes on the number and function of the late endothelial progenitor cells in peripheral blood of the patients before and after the treatment were compared between the two groups. The changes on the pulmonary artery pressure were also compared. The number of the late endothelial progenitor cells in peripheral blood of the treatment group increased and the function was enhanced. The pulmonary artery pressure was reduced. The difference before and after the treatment and with the control group was statistically significant (p<0.05). The changes on the number and function of the late endothelial progenitor cells in peripheral blood and the pulmonary artery pressure before and after the treatment of the control group were not statistically significant (p>0.05). The Rho-kinase inhibitor Fasudil increased the number and enhanced the function of the late endothelial progenitor cells in peripheral blood of COPD patients with pulmonary artery hypertension.

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Influence of Rho Kinase Inhibitor Fasudil on Late Endothelial Progenitor Cells in Peripheral Blood of COPD Patients with Pulmonary Artery Hypertension
Published
2014-05-20
How to Cite
1.
Liu P, Zhang H, Tang Y, Sheng C, Liu J, Zeng Y. Influence of Rho Kinase Inhibitor Fasudil on Late Endothelial Progenitor Cells in Peripheral Blood of COPD Patients with Pulmonary Artery Hypertension. Bosn J of Basic Med Sci [Internet]. 2014May20 [cited 2020Aug.15];14(1):40-4. Available from: http://www.bjbms.org/ojs/index.php/bjbms/article/view/2295
Section
Translational and Clinical Research