Changes in Serum Homocysteine Level Follow Two Different Trends in Patients During Early Post Myocardial Infarction Period

  • Amina Valjevac Institute of Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
  • Alen Džubur Clinic for Heart Diseases and Rheumatism, University of Sarajevo Clinics Centre
  • Emina Nakaš-Ićindić Institute of Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
  • Almira Hadžović-Džuvo Institute of Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
  • Asija Zaćiragić Institute of Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
  • Orhan Lepara Institute of Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
  • Amila Arslanagić Clinic for Heart Diseases and Rheumatism, University of Sarajevo Clinics Centre
Keywords: homocysteine, acute myocardial infarction, post myocardial period, risk factor

Abstract

The evolution of homocysteine (Hcy) changes after acute myocardial infarction is still not elucidated. Serum Hcy concentration has been shown to increase between acute and convalescent period after myocardial infarction and stroke, Also a decrease in serum Hcy during acute phase was observed, It is still not clear whether the Hcy is a culprit or an innocent bystander in cardiovascular diseases, Addressing the discrepancies in Hcy changes in patients with acute myocardial infarction might give insight in Hcy role in cardiovascular diseases and offer implications both for the clinical interpretation and patients risk stratification, The aim of the study was to evaluate serum Hcy concentration changes during early post myocardial infarction, The study included 55 patients with AMI from the Clinics for Heart Diseases and Rheumatism at University of Sarajevo Clinics Centre, For Hcy analysis blood was collected on day 2 and 5 after the AMI onset, Serum Hcy concentration was determined quantitatively with fluorescent polarisation immunoassay on AxSYM system, Cluster analysis revealed two groups ofAMI patients with different trends of serum Hcy changes, Increase in serum Hcy concentration was observed in 33 (60,0%) patients (AMI 1 group), while in 22 (40,0%) patients a decrease was observed (AMI 2 group), On day 2, patients in AMI 2 group had significantly higher mean Hcy concentration compared to AMI 1 group of patients (15,27±0,96 and 11,59±0,61 μmol/L p<0,05), On day 5, no significant difference in mean Hcy level between AMI 1 and AMI 2 group of patients was observed (14,86±1,1 vs, 12,75±0,74 μmol/L respectively), Significant differences between AMI 1 and AMI 2 patients were observed in VLDLC levels and CK-MB activity on day 2,

Patients in AMI 1 group had significant increase in platelets count from day 2 to day 5 (230,1±11,6 vs. 244,2±11,0; p<0,05). Our study of serial Hcy changes in patients with AMI revealed two different patterns of Hcy changes in early post infarction period which might reflect two distinct populations of AMI patients. Although further research is necessary, possible explanation for the observed findings could be a different genetic background, vitamin and oxidative status of patients with AMI.

Downloads

Download data is not yet available.
Published
2009-05-20
How to Cite
1.
Valjevac A, Džubur A, Nakaš-Ićindić E, Hadžović-Džuvo A, Zaćiragić A, Lepara O, Arslanagić A. Changes in Serum Homocysteine Level Follow Two Different Trends in Patients During Early Post Myocardial Infarction Period. Bosn J of Basic Med Sci [Internet]. 2009May20 [cited 2019Dec.10];9(2):161-73. Available from: http://www.bjbms.org/ojs/index.php/bjbms/article/view/2837
Section
Biochemistry

Most read articles by the same author(s)

1 2 > >>