Characteristics and prognostic factors of age-stratified high-grade intracranial glioma patients: A population-based analysis

Authors

  • Yun Sun Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
  • Zhi-Yong Xiong Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
  • Peng-Fei Yan Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
  • Liang-Lei Jiang Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
  • Chuan-Sheng Nie Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
  • Xuan Wang Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

DOI:

https://doi.org/10.17305/bjbms.2019.4213

Keywords:

prognosis, surveillance, Epidemiology and End Results (SEER) Program, SEER, glioma

Abstract

We evaluated characteristics and different prognostic factors for survival in age-stratified high-grade glioma in a U.S. cohort. Eligible patients were identified in the Surveillance, Epidemiology, and End Results (SEER) registries and stratified into 3 age groups: 20–39 years old (1,043 patients), 40–59 years old (4,503 patients), and >60 years old (5,045 patients). Overall and cancer-related survival data were obtained. Cox models were built to analyze the outcomes and risk factors. It showed that race was a prognostic factor for survival in patients 40 to 59 years old and in patients ≥60 years old. Partial resection was associated with lower overall survival and cause-specific survival in all age groups (overall survival: 20–39 yr: HR = 6.41; 40–59 yr: HR = 4.84; >60 yr: HR = 5.06; cause-specific survival: 20–39 yr: HR = 5.87; 40–59 yr: HR = 4.01; >60 yr: HR = 3.36). The study highlights that, while some prognostic factors are universal, others are age-dependent. The effectiveness of treatment approaches differs for patients in different age groups. Results of this study may help to develop personalized treatment protocols for glioma patients of different ages.

Characteristics and prognostic factors of age-stratified high-grade intracranial glioma patients: A population-based analysis

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Published

08-11-2019

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Section

Translational and Clinical Research

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How to Cite

1.
Characteristics and prognostic factors of age-stratified high-grade intracranial glioma patients: A population-based analysis. Biomol Biomed [Internet]. 2019 Nov. 8 [cited 2024 Mar. 29];19(4):375-83. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/4213