2024-03-28T12:00:03Z
https://www.bjbms.org/ojs/index.php/bjbms/oai
oai:ojs2.www.bjbms.org:article/203
2021-03-16T20:11:51Z
bjbms:REV
driver
Progress on diabetic cerebrovascular diseases
Zhou, Houguang
Zhang, Xiaoming
Lu, Jianfeng
Diabetes
Cerebrovascular diseases
Diabetic cerebral large vascular disease
Diabetic cerebral small vessel disease
Diabetic cerebrovascular diseases are defined as cerebral vascular diseases induced by diabetes with sugar, fat and a series of nutrient substance metabolic disorders, resulting in intracranial large and small vessel diseases. About 20%-40% patients with type 2 diabetes suffer from cerebral blood vessel diseases. Diabetic cerebrovascular diseases are the main causes of death in patients with diabetes mellitus. The major clinical manifestations are asymptomatic cerebral atherosclerosis, stroke, cerebral small vessel disease and acute cerebral vascular disease. The pathogenesis, clinical characteristics, treatment and prognosis of diabetic cerebrovascular disease are obviously different from non-diabetic cerebral vascular diseases. This paper will focus on the diabetic cerebrovascular disease, including its latest research progress. Diabetic cerebral large vascular disease and diabetic cerebral small vessel disease will be reviewed here.
Association of Basic Medical Sciences of FBIH
2014-11-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/185
10.17305/bjbms.2014.4.203
Biomolecules and Biomedicine; Vol. 14 No. 4 (2014); 185-190
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/185/69
https://www.bjbms.org/ojs/index.php/bjbms/article/view/185/2041
Copyright (c) 2015 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/205
2021-03-16T20:13:15Z
bjbms:REV
driver
Epigenetic alterations of the Wnt signaling pathway in cancer: a mini review
Serman, Ljiljana
Nikuseva Martic, Tamara
Serman, Alan
Vranic, Semir
Cancer
epigenetics
Wnt signaling pathway
Epigenetic mechanisms play a crucial role in cellular proliferation, migration and differentiation in both normal and neoplastic development. One of the key signaling pathways whose components are altered through the epigenetic mechanisms is the Wnt signaling pathway. In this review, we briefly discuss the key concepts of epigenetics and focus on the recent advances in the Wnt signaling pathway research and its potential diagnostic and therapeutic implications.
Association of Basic Medical Sciences of FBIH
2014-11-12
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/a191
10.17305/bjbms.2014.4.205
Biomolecules and Biomedicine; Vol. 14 No. 4 (2014); 191-194
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/a191/70
https://www.bjbms.org/ojs/index.php/bjbms/article/view/a191/2042
Copyright (c) 2015 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/247
2021-03-17T14:52:25Z
bjbms:REV
driver
Imaging Characteristics of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leucoencephalopathy (CADASIL)
Stojanov, Dragan
Vojinovic, Slobodan
Aracki-Trenkic, Aleksandra
Tasic, Aleksandar
Benedeto-Stojanov, Daniela
Ljubisavljevic, Srdjan
Vujnovic, Sasa
CADASIL
MRI
computed tomography
white matter hyperintensities
cerebral microbleeds
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) is an autosomal dominant vascular disorder. Diagnosis and follow-up in patients with CADASIL are based mainly on magnetic resonance imaging (MRI). MRI shows white matter hyperintensities (WMHs), lacunar infarcts and cerebral microbleeds (CMBs). WMHs lesions tend to be symmetrical and bilateral, distributed in the periventricular and deep white matter. The anterior temporal lobe and external capsules are predilection sites for WMHs, with higher specificity and sensitivity of anterior temporal lobe involvement compared to an external capsule involvement. Lacunar infarcts are presented by an imaging signal that has intensity of cerebrospinal fluid in all MRI sequences. They are localized within the semioval center, thalamus, basal ganglia and pons. CMBs are depicted as focal areas of signal loss on T2 images which increases in size on the T2*-weighted gradient echo planar images (“blooming effect”).
Association of Basic Medical Sciences of FBIH
2015-02-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/247
10.17305/bjbms.2015.247
Biomolecules and Biomedicine; Vol. 15 No. 1 (2015); 1-8
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/247/106
https://www.bjbms.org/ojs/index.php/bjbms/article/view/247/2057
oai:ojs2.www.bjbms.org:article/449
2021-03-17T15:24:15Z
bjbms:REV
driver
Prostate cancer stroma: an important factor in cancer growth and progression
Krušlin, Božo
Ulamec, Monika
Tomas, Davor
Prostate cancer
stroma
myofibroblast
extracellular matrix components
Reactive stromal changes that occur in different human cancers might play a role in local tumor spreading and progression. Studies done on various human cancers have shown activated stromal cell phenotypes, modified extracellular matrix (ECM) composition, and increased microvessel density. Furthermore, they exhibit biological markers consistent with stroma at the site of wound repair. In prostate cancer, stroma is composed of fibroblasts, myofibroblasts, endothelial cells and immune cells. Predominant cells in the tumorous stroma are, however, fibroblasts/ myofibroblasts. They are responsible for the synthesis, deposition and remodeling of the ECM. Epithelial tumorous cells, in interaction with stromal cells and with the help of various molecules of ECM, create a microenvironment suitable for cancer cell proliferation, movement, and differentiation. In this review, we discussed the role of different stromal components in prostate cancer as well as their potential prognostic and therapeutic significance.
Association of Basic Medical Sciences of FBIH
2015-05-13
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/449
10.17305/bjbms.2015.449
Biomolecules and Biomedicine; Vol. 15 No. 2 (2015); 1-8
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/449/126
https://www.bjbms.org/ojs/index.php/bjbms/article/view/449/2069
Copyright (c) 2015 Krušlin et al.; licensee ABMSFBIH. This is an Open Access article distributed under the terms of the Creative Commons Attribution License
oai:ojs2.www.bjbms.org:article/525
2020-09-18T17:45:30Z
bjbms:REV
driver
Biomaterials and host versus graft response: a short review
Velnar, Tomaz
Bunc, Gorazd
Klobucar, Robert
Gradisnik, Lidija
host versus graft disease
biomaterial
wound healing
transplant
tissue
Biomaterials and biotechnology are increasing becoming an important area in modern medicine. The main aim in this area is the development of materials, which are biocompatible to normal tissue. Tissue-implant interactions with molecular, biological and cellular characteristics at the implant-tissue interface are important for the use and development of implants. Implantation may cause an inflammatory and immune response in tissue, foreign body reaction, systemic toxicity and imminent infection. Tissue-implant interactions determine the implant life-period. The aims of the study are to consider the biological response to implants. Biomaterials and host reactions to implants and their mechanisms are also briefly discussed.
Association of Basic Medical Sciences of FBIH
2016-02-19
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/525
10.17305/bjbms.2016.525
Biomolecules and Biomedicine; Vol. 16 No. 2 (2016); 82-90
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/525/225
https://www.bjbms.org/ojs/index.php/bjbms/article/view/525/1589
Copyright (c) 2016 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/594
2021-03-15T21:41:02Z
bjbms:REV
driver
Lyme Borreliosis: Is there a preexisting (natural) variation in antimicrobial susceptibility among Borrelia burgdorferi strains?
Hodzic, Emir
Borrelia burgdorferi
antibiotics
persistence
antimicrobial resistance
antimicrobial tolerance
ticks
small mammals
The development of antibiotics changed the world of medicine and has saved countless human and animal lives. Bacterial resistance/tolerance to antibiotics have spread silently across the world and has emerged as a major public health concern. The recent emergence of pan-resistant bacteria can overcome virtually any antibiotic and poses a major problem for their successful control. Selection for antibiotic resistance may take place where an antibiotic is present: in the skin, gut, and other tissues of humans and animals and in the environment. Borrelia burgdorferi, the etiological agents of Lyme borreliosis, evades host immunity and establishes persistent infections in its mammalian hosts. The persistent infection poses a challenge to the effective antibiotic treatment, as demonstrated in various animal models. An increasingly heterogeneous subpopulation of replicatively attenuated spirochetes arises following treatment, and these persistent antimicrobial tolerant/resistant spirochetes are non-cultivable. The non-cultivable spirochetes resurge in multiple tissues at 12 months after treatment, with B. burgdorferi-specific DNA copy levels nearly equivalent to those found in shame-treated experimental animals. These attenuated spirochetes remain viable, but divide slowly, thereby being tolerant to antibiotics. Despite the continued non-cultivable state, RNA transcription of multiple B. burgdorferi genes was detected in host tissues, spirochetes were acquired by xenodiagnostic ticks, and spirochetal forms could be visualized within ticks and mouse tissues. A number of host cytokines were up- or down-regulated in tissues of both shame- and antibiotic-treated mice in the absence of histopathology, indicating a lack of host response to the presence of antimicrobial tolerant/resistant spirochetes.
Association of Basic Medical Sciences of FBIH
2015-07-08
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/594
10.17305/bjbms.2015.594
Biomolecules and Biomedicine; Vol. 15 No. 3 (2015); 1-13
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/594/147
https://www.bjbms.org/ojs/index.php/bjbms/article/view/594/2003
Copyright (c) 2015 Emir Hodzic
oai:ojs2.www.bjbms.org:article/636
2021-03-17T18:32:28Z
bjbms:REV
driver
Dystrophin and the two related genetic diseases, Duchenne and Becker muscular dystrophies
Le Rumeur, Elisabeth
Dystrophin
Becker muscular dystrophy
Duchenne muscular dystrophy
exon skipping
micro-dystrophin
Mutations of the dystrophin DMD gene, essentially deletions of one or several exons, are the cause of two devastating and to date incurable diseases, Duchenne (DMD) and Becker (BMD) muscular dystrophies. Depending upon the preservation or not of the reading frame, dystrophin is completely absent in DMD, or present in either a mutated or a truncated form in BMD. DMD is a severe disease which leads to a premature death of the patients. Therapy approaches are evolving with the aim to transform the severe DMD in the BMD form of the disease by restoring the expression of a mutated or truncated dystrophin. These therapies are based on the assumption that BMD is a mild disease. However, this is not completely true as BMD patients are more or less severely affected and no molecular basis of this heterogeneity of the BMD form of the disease is yet understood. The aim of this review is to report for the correlation between dystrophin structures in BMD deletions in view of this heterogeneity and to emphasize that examining BMD patients in details is highly relevant to anticipate for DMD therapy effects.
Association of Basic Medical Sciences of FBIH
2015-07-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/636
10.17305/bjbms.2015.636
Biomolecules and Biomedicine; Vol. 15 No. 3 (2015); 14-20
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/636/152
https://www.bjbms.org/ojs/index.php/bjbms/article/view/636/2096
Copyright (c) 2015 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/783
2021-02-02T18:31:18Z
bjbms:REV
driver
Tumor suppressor maspin as a modulator of host immune response to cancer
Dzinic, Sijana H.
Bernardo, Maria M.
Oliveira, Daniel S.M.
Wahba, Marian
Sakr, Wael
Sheng, Shijie
Anticancer immunity
immunosuppression
immunogenicity
cancer immunoediting
innate immunity
adaptive immunity
serine protease inhibitors
tumor suppressor
maspin
autoantigen
differentiation
epigenetic
cancer stem cells
cellular plasticity
tumor
Despite the promising clinical outcome, the primary challenge of the curative cancer immunotherapy is to overcome the dichotomy of the immune response: tumor-evoked immunostimulatory versus tumor-induced immunosuppressive. The goal needs to be two-fold, to re-establish sustainable antitumor-cancer immunity and to eliminate immunosuppression. The successful elimination of cancer cells by immunosurveillance requires the antigenic presentation of the tumor cells or tumor-associated antigens and the expression of immunostimulatory cytokines and chemokines by cancer and immune cells. Tumors are heterogeneous and as such, some of the tumor cells are thought to have stem cell characteristics that enable them to suppress or desensitize the host immunity due to acquired epigenetic changes. A central mechanism underlying tumor epigenetic instability is the increased histone deacetylase (HDAC)-mediated repression of HDAC-target genes regulating homeostasis and differentiation. It was noted that pharmacological HDAC inhibitors are not effective in eliminating tumor cells partly because they may induce immunosuppression. We have shown that epithelial-specific tumor suppressor maspin, an ovalbumin-like non-inhibitory serine protease inhibitor, reprograms tumor cells toward better differentiated phenotypes by inhibiting HDAC1. Recently, we uncovered a novel function of maspin in directing host immunity towards tumor elimination. In this review, we discuss the maspin and maspin/HDAC1 interplay in tumor biology and immunology. We propose that maspin based therapies may eradicate cancer.
Association of Basic Medical Sciences of FBIH
2015-10-25
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/783
10.17305/bjbms.2015.783
Biomolecules and Biomedicine; Vol. 15 No. 4 (2015); 1-6
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/783/185
https://www.bjbms.org/ojs/index.php/bjbms/article/view/783/1892
Copyright (c) 2015 Dzinic et al.
oai:ojs2.www.bjbms.org:article/794
2021-03-01T17:39:59Z
bjbms:REV
driver
Do glucagonomas always produce glucagon?
Wewer Albrechtsen, Nicolai Jacob
Challis, Benjamin
Damjanov, Ivan
Holst, Jens Juul
Glucagonoma
neuroendocrine tumours
NETs
hyperglucagonemia
GLP-1
Proglucagon
Pancreatic islet α-cell tumours that overexpress proglucagon are typically associated with the glucagonoma syndrome, a rare disease entity characterised by necrolytic migratory erythema, impaired glucose tolerance, thromboembolic complications and psychiatric disturbances. Paraneoplastic phenomena associated with enteric overexpression of proglucagon-derived peptides are less well recognized and include gastrointestinal dysfunction and hyperinsulinaemic hypoglycaemia. The diverse clinical manifestations associated with glucagon-expressing tumours can be explained, in part, by the repertoire of tumorally secreted peptides liberated through differential post-translational processing of tumour-derived proglucagon. Proglucagon-expressing tumours may be divided into two broad biochemical subtypes defined by either secretion of glucagon or GLP-1, GLP-2 and the glucagon-containing peptides, glicentin and oxyntomodulin, due to an islet α-cell or enteroendocrine L-cell pattern of proglucagon processing, respectively. In the current review we provide an updated overview of the clinical presentation of proglucagon-expressing tumours in relation to known physiological actions of proglucagon-derived peptides and suggest that detailed biochemical characterisation of the peptide repertoire secreted from these tumours may provide new opportunities for diagnosis and clinical management.
Association of Basic Medical Sciences of FBIH
2016-02-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/794
10.17305/bjbms.2015.794
Biomolecules and Biomedicine; Vol. 16 No. 1 (2016); 1-7
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/794/182
https://www.bjbms.org/ojs/index.php/bjbms/article/view/794/1980
Copyright (c) 2015 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/801
2020-09-18T17:51:51Z
bjbms:REV
driver
Brachiomedian artery (arteria brachiomediana) revisited: a comprehensive review
Kachlik, David
Konarik, Marek
Riedlova, Jitka
Baca, Vaclav
Arteria brachiomediana
arteria brachiomediana superficialis
arterial variation
brachiomedian artery
superficial brachiomedian artery
This article reviews in detail the superficial brachiomedian artery (arteria brachiomediana superficialis), a very rare variant of the main arterial trunks of the upper limb. It branches either from the axillary artery or the brachial artery, descends superficially in the arm (similar to the course of the superficial brachial artery) and continues across the cubital fossa, runs superficially in the forearm, approaches the median nerve and enters the carpal canal to reach the hand. It usually terminates in the superficial palmar arch. The first drawing was published, in 1830, and the first description was published, in 1844. Altogether, to our knowledge, only 31 cases of a true, superficial brachiomedian artery have been reported (Some cases are incorrectly reported as superficial brachioradiomedian artery or superficial brachioulnomedian artery). Based on a meta-analysis of known, available studies, the incidence is 0.23% in Caucasians and 1.48% in Mongolians. Knowing whether or not this arterial variant is present is important in clinical medicine and relevant for: The catheterization via the radial or ulnar artery; harvesting the vascular pedicle for a forearm flap based on the radial, ulnar or superficial brachiomedian arteries; the possible collateral circulation in cases of the arterial closure; and the surgical management of carpal tunnel syndrome. Its presence can elevate the danger of an injury to the superficially located variant artery or of an accidental injection.
Association of Basic Medical Sciences of FBIH
2016-03-10
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/801
10.17305/bjbms.2016.801
Biomolecules and Biomedicine; Vol. 16 No. 2 (2016); 91-101
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/801/228
https://www.bjbms.org/ojs/index.php/bjbms/article/view/801/1590
Copyright (c) 2016 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/917
2020-09-18T18:36:46Z
bjbms:REV
driver
The mouse prostate: a basic anatomical and histological guideline
Oliveira, Daniel S.M.
Dzinic, Sijana
Bonfil, Alan I
Saliganan, Allen D
Sheng, Shijie
Bonfil, R. Daniel
mouse models
prostate
prostate cancer
mouse prostate histology
mouse prostate anatomy
Despite substantial similarities in embryological, cellular and molecular biology features, human and mouse prostates differ in organ morphology and tissue architecture. Thus, a clear understanding of the anatomy and histology of the mouse prostate is essential for the identification of urogenital phenotypes in genetically engineered mice, as well as for the study of the etiology, development, and treatment of human prostatic diseases for which mouse models are used. The purpose of this manuscript is to provide a brief guide for the dissection of the mouse prostate and the identification of its different lobes and histology, to both basic researchers and medical pathologists who are unfamiliar with mouse tissues.
Association of Basic Medical Sciences of FBIH
2016-02-10
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/917
10.17305/bjbms.2016.917
Biomolecules and Biomedicine; Vol. 16 No. 1 (2016); 8-13
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/917/191
https://www.bjbms.org/ojs/index.php/bjbms/article/view/917/1602
Copyright (c) 2015 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/919
2021-02-17T22:13:00Z
bjbms:REV
driver
Apoptosis in pancreatic β-islet cells in Type 2 diabetes
Tomita, Tatsuo
Amyloid
apoptosis
β-cells
caspase
hyperglycemia
insulin
islets of Langerhans
knockout mouse
pro-apoptotic genes
Type 2 diabetes
Apoptosis plays important roles in the pathophysiology of Type 2 diabetes mellitus (T2DM). The etiology of T2DM is multifactorial, including obesity-associated insulin resistance, defective insulin secretion, and loss of β-cell mass through β-cell apoptosis. β-cell apoptosis is mediated through a milliard of caspase family cascade machinery in T2DM. The glucose-induced insulin secretion is the principle pathophysiology of diabetes and insufficient insulin secretion results in chronic hyperglycemia, diabetes. Recently, hyperglycemia-induced β-cell apoptosis has been extensively studied on the balance of pro-apoptotic Bcl-2 proteins (Bad, Bid, Bik, and Bax) and anti-apoptotic Bcl family (Bcl-2 and Bcl-xL) toward apoptosis in vitro isolated islets and insulinoma cell culture. Apoptosis can only occur when the concentration of pro-apoptotic Bcl-2 exceeds that of anti-apoptotic proteins at the mitochondrial membrane of the intrinsic pathway. A bulk of recent research on hyperglycemia-induced apoptosis on β-cells unveiled complex details on glucose toxicity on β-cells in molecular levels coupled with cell membrane potential by adenosine triphosphate generation through K+ channel closure, opening Ca2+ channel and plasma membrane depolarization. Furthermore, animal models using knockout mice will shed light on the basic understanding of the pathophysiology of diabetes as a glucose metabolic disease complex, on the balance of anti-apoptotic Bcl family and pro-apoptotic genes. The cumulative knowledge will provide a better understanding of glucose metabolism at a molecular level and will lead to eventual prevention and therapeutic application for T2DM with improving medications.
Association of Basic Medical Sciences of FBIH
2016-08-02
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/919
10.17305/bjbms.2016.919
Biomolecules and Biomedicine; Vol. 16 No. 3 (2016); 162-179
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/919/252
https://www.bjbms.org/ojs/index.php/bjbms/article/view/919/1951
Copyright (c) 2016 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/1072
2021-02-17T22:12:34Z
bjbms:REV
driver
Comparison of local infiltration and epidural analgesia for postoperative pain control in total knee arthroplasty and total hip arthroplasty: A systematic review and meta-analysis
Yan, Huan
Cang, Jing
Xue, Zhanggang
Lu, Jianfeng
Wang, Hao
Total knee arthroplasty
total hip arthroplasty
local infiltration
epidural analgesia
meta-analysis
Pain management after total knee arthroplasty (TKA) and total hip arthroplasty should permit early mobilization with minimal pain. Local infiltration analgesia (LIA) is a new popular method for decreasing postoperative pain. The goal of this meta-analysis is to evaluate the efficacy of LIA in comparison with epidural analgesia. A literature search was performed in PubMed, EMBASE, the OVID database, Web of Science, and the Cochrane Library databases. The risk of bias was assessed using the Cochrane collaboration tool. Outcomes of interest included visual analog scale score, range of flexion, length of stay, and complications. Nine trials involving 537 patients met the inclusion criteria. LIA provides better pain relief and larger range of motion in TKA patients compared to epidural analgesia at the late postoperative period. No significant difference was observed in regard to the length of stay and complications. The current evidence shows that the use of local infiltration is effective for postoperative pain management in TKA patients. More high-quality randomized controlled trials with long-term follow-up are required for examining the long-term efficacy and safety of local infiltration.
Association of Basic Medical Sciences of FBIH
2016-11-10
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/1072
10.17305/bjbms.2016.1072
Biomolecules and Biomedicine; Vol. 16 No. 4 (2016); 239-246
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/1072/251
https://www.bjbms.org/ojs/index.php/bjbms/article/view/1072/1939
Copyright (c) 2106 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/1201
2021-02-17T22:12:48Z
bjbms:REV
driver
Atypical presentation of posterior reversible encephalopathy syndrome: Clinical and radiological characteristics in eclamptic patients
Aracki-Trenkić, Aleksandra
Stojanov, Dragan
Trenkić, Milan
Radovanović, Zoran
Ignjatović, Jelena
Ristić, Saša
Trenkić-Bozinović, Marija
Posterior reversible encephalopathy syndrome
magnetic resonance
computed tomography
brain
vasogenic edema
Posterior reversible encephalopathy syndrome (PRES) is an obstetric emergency frequently occurring in a pregnant or puerperal woman, manifested with an acute headache, consciousness impairment, seizures, and visual deficits and is associated with white matter changes predominantly affecting the posterior parietal and occipital lobes of the brain. Apart from the above-described typical location of the changes, the most common atypical location involves the brain stem and basal ganglia. Since magnetic resonance imaging (MRI) is more sensitive and specific imaging technique compared to computerized tomography, establishing the diagnosis and follow-up in patients with PRES is based mainly on MRI findings. It is particularly important not to exclude PRES as a possible diagnosis when we have the appropriate clinical presentation accompanied by the atypical radiological findings, since this clinical-radiological syndrome can often be manifested with an atypical MRI image.
Association of Basic Medical Sciences of FBIH
2016-08-02
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/1201
10.17305/bjbms.2016.1201
Biomolecules and Biomedicine; Vol. 16 No. 3 (2016); 180-186
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/1201/257
https://www.bjbms.org/ojs/index.php/bjbms/article/view/1201/1952
Copyright (c) 2016 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/1424
2021-02-11T19:58:19Z
bjbms:REV
driver
Clinical significance of routine lacrimal sac biopsy during dacryocystorhinostomy: A comprehensive review of literature
Koturović, Zoran
Knežević, Miroslav
Rašić, Dejan M.
lacrimal sac
histopathology
specific pathology
chronic dacryocystitis
dacryocystorhinostomy
The main purpose of this paper is to provide the information about the incidence and types of pathology of secondary acquired obstructions of the lacrimal excretory outflow system caused by primary lacrimal sac non-neoplastic and neoplastic lesions. After a thorough literature search, 17 case-control studies were found and selected, data were extracted and categorized, to evaluate specific lacrimal sac pathology mimicking inflammation. A total of 3865 histopathologically examined lacrimal sac wall biopsy specimens from 3662 patients, taken during dacryocystorhinostomy for clinically presumed primary chronic dacryocystitis, were analyzed. The most common reported histopathological finding was non-specific chronic inflammation with or without fibrosis (94.15% of cases). Lacrimal sac-specific pathologies were present in 226 (5.85%) cases. Unsuspected lacrimal sac-specific pathologies were present in 55/226 (24.34%) cases. Almost 45% of primary lacrimal sac malignant neoplasms were not suspected, preoperatively and intraoperatively. Tumor-like lesions of the lacrimal sac were the most common pathology found: (1) lacrimal stones-dacryoliths, (2) pyogenic granuloma, (3) granulation tissues, (4) reactive lymphoid hyperplasia, and (5) lacrimal sac-specific inflammation (Wegener’s granulomatosis and sarcoidosis). Neoplastic pathology was found in 55/3865 (1.42%) lacrimal sac wall biopsy specimens; of those, malignant cases were 2.24 times more frequent than benign. Lymphoma was the most common preoperatively unsuspected or intraoperatively unexpected neoplastic pathology. This analysis of the relevant literature highlights the value of routine lacrimal sac biopsy during surgery for clinically presumed primary acquired nasolacrimal duct obstruction.
Association of Basic Medical Sciences of FBIH
2017-02-21
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/1424
10.17305/bjbms.2016.1424
Biomolecules and Biomedicine; Vol. 17 No. 1 (2017); 1-8
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/1424/283
https://www.bjbms.org/ojs/index.php/bjbms/article/view/1424/1927
Copyright (c) 2016 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/1505
2021-02-04T21:16:00Z
bjbms:REV
driver
Meta-analysis of interleukin 6, 8, and 10 between off-pump and on-pump coronary artery bypass groups
Meng, Fanbo
Ma, Jianghong
Wang, Wei
Lin, Baisong
Coronary artery bypass
interleukins
meta-analysis
IL-6
IL-8
IL-10
off-pump coronary artery bypass surgery
on-pump coronary artery bypass surgery
This study aimed to evaluate the role of off-pump coronary artery bypass (CAB) surgery on the decrease of postoperative inflammatory responses in patients. We systematically searched databases of PubMed and Embase to select the related studies. Interleukin (IL) 6, 8, and 10 were used as outcomes and pooled analysis was performed using R 3.12 software. Standardized mean differences (SMDs) and their 95% confidence intervals (95% CIs) were considered as effect estimates. A total of 27 studies, including 1340 participants, were recruited in this meta-analysis. The pooled analyses showed that postoperative concentration of IL-10 at 12 hours was significantly lower in off-pump CAB group compared to on-pump CAB group (SMD = −1.3640, 95% CI = −2.0086-−0.7193). However, no significant differences were found in pre and postoperative concentrations of IL-6 and 8 between off-pump and on-pump CAB groups. These results suggest that there is no advantage of off-pump CAB surgery in the reduction of inflammation compared to on-pump CAB surgery.
Association of Basic Medical Sciences of FBIH
2017-05-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/1505
10.17305/bjbms.2017.1505
Biomolecules and Biomedicine; Vol. 17 No. 2 (2017); 85-94
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/1505/304
https://www.bjbms.org/ojs/index.php/bjbms/article/view/1505/1908
Copyright (c) 2017 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/1811
2021-02-17T22:10:18Z
bjbms:REV
driver
Apocrine carcinoma of the breast: A brief update on the molecular features and targetable biomarkers
Vranic, Semir
Feldman, Rebecca
Gatalica, Zoran
breast cancer
special types
apocrine carcinoma
androgen receptor
biomarkers
targeted therapy
Apocrine carcinoma of the breast is a rare, primary breast cancer characterized by the apocrine morphology, estrogen receptor-negative and androgen receptor-positive profile with a frequent overexpression of Her-2/neu protein (~30%). Apart from the Her-2/neu target, advanced and/or metastatic apocrine carcinomas have limited treatment options. In this review, we briefly describe and discuss the molecular features and new theranostic biomarkers for this rare mammary malignancy. The importance of comprehensive profiling is highlighted due to synergistic and potentially antagonistic molecular events in the individual patients.
Association of Basic Medical Sciences of FBIH
2017-02-21
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/1811
10.17305/bjbms.2016.1811
Biomolecules and Biomedicine; Vol. 17 No. 1 (2017); 9-11
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/1811/291
https://www.bjbms.org/ojs/index.php/bjbms/article/view/1811/1928
Copyright (c) 2016 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/1908
2021-01-17T20:32:08Z
bjbms:REV
driver
Cancer metastasis - tricks of the trade
Zeeshan, Rabia
Mutahir, Zeeshan
Cancer
metastasis
tumor cell infiltration
disseminated tumor cells
circulating tumor cells
Decades of cancer research have unraveled genetic, epigenetic and molecular pathways leading to plausible therapeutic targets; many of which hold great promise in improving clinical outcomes. Metastatic tumors become evident early on and are one of the major causes of cancer-related fatalities worldwide. This review depicts the sequential events of cancer metastasis. Genetic and epigenetic heterogeneity influences local tumor cell invasion, intravasation, survival in circulation, extravasation and colonization to distant sites. Each sequential event is associated with heterogeneous tumor microenvironment, gain of competence, unique population of cancer stem cells (CSCs), circulatory pathway, compatible niche and immune system support. A tight regulation of metastasis-promoting mechanisms and, in parallel, evading inhibitory mechanisms contribute to the severity and site of metastasis. A comprehensive understanding of tumor cell fate as an individual entity, as well as in combination with different promoting factors and associated molecular mechanisms, is anticipated in the coming years. This will enable scientists to depict design strategies for targeted cancer therapies.
Association of Basic Medical Sciences of FBIH
2017-08-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/1908
10.17305/bjbms.2017.1908
Biomolecules and Biomedicine; Vol. 17 No. 3 (2017); 172-182
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/1908/302
https://www.bjbms.org/ojs/index.php/bjbms/article/view/1908/1855
Copyright (c) 2017 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/1930
2021-02-17T22:10:04Z
bjbms:REV
driver
TAFRO syndrome: New subtype of idiopathic multicentric Castleman disease
Srkalovic, Gordan
Marijanovic, Inga
Srkalovic, Maya B
Fajgenbaum, David C
TAFRO
Castleman disease
lymphoproliferative disorders
interleukin-6
cytokines
cytokine storm
Castleman disease (CD) describes a group of three rare and poorly understood lymphoproliferative disorders that have heterogeneous clinical symptoms and common lymph node histopathological features. Unicentric CD (UCD) involves a single region of enlarged nodes. Multicentric CD (MCD) involves multiple regions of enlarged lymph nodes, constitutional symptoms, and organ dysfunction due to a cytokine storm often including interleukin 6. MCD is further divided into Human Herpes Virus-8 (HHV-8)-associated MCD, which occurs in immunocompromised individuals, and HHV-8-negative/idiopathic MCD (iMCD). Recently, iMCD has been further sub-divided into patients with TAFRO syndrome, which involves thrombocytopenia (T), anasarca (A), fevers (F), reticulin myelofibrosis (R), organomegaly (O), and normal or only slightly elevated immunoglobulin levels, and those who do not have TAFRO syndrome. Non-TAFRO iMCD patients typically have thrombocytosis, less severe fluid accumulation, and hypergammaglobulinemia. iMCD patients with TAFRO syndrome may have a worse prognosis, but more research is needed.
Association of Basic Medical Sciences of FBIH
2017-05-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/1930
10.17305/bjbms.2017.1930
Biomolecules and Biomedicine; Vol. 17 No. 2 (2017); 81-84
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/1930/296
https://www.bjbms.org/ojs/index.php/bjbms/article/view/1930/1906
Copyright (c) 2017 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/1961
2021-01-17T20:35:37Z
bjbms:REV
driver
Apoptosis of pancreatic β-cells in Type 1 diabetes
Tomita, Tatsuo
Apoptosis
autoimmunity
β-cells
Bcl family
caspases
cytokines
insulitis
Type 1 diabetes
Type 1 diabetes mellitus (T1DM) results from autoimmune destruction of pancreatic β-cells after an asymptomatic period over years. Insulitis activates antigen presenting cells, which trigger activating CD4+ helper-T cells, releasing chemokines/cytokines. Cytokines activate CD8+ cytotoxic–T cells, which lead to β-cell destruction. Apoptosis pathway consists of extrinsic (receptor-mediated) and intrinsic (mitochondria-driven) pathway. Extrinsic pathway includes Fas pathway to CD4+-CD8+ interaction, whereas intrinsic pathway includes mitochondria-driven pathway at a balance between anti-apoptotic B-cell lymphoma (Bcl)-2 and Bcl-xL and pro-apoptotic Bad, Bid, and Bik proteins. Activated cleaved caspse-3 is the converging point between extrinsic and intrinsic pathway. Apoptosis takes place only when pro-apoptotic proteins exceed anti-apoptotic proteins. Since the concordance rate of T1DM in identical twins is about 50%, environmental factors are involved in the development of T1DM, opening a door to find means to detect and prevent further development of autoimmune β-cell destruction for a therapeutic application.
Association of Basic Medical Sciences of FBIH
2017-08-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/1961
10.17305/bjbms.2017.1961
Biomolecules and Biomedicine; Vol. 17 No. 3 (2017); 183-193
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/1961/305
https://www.bjbms.org/ojs/index.php/bjbms/article/view/1961/1856
Copyright (c) 2017 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/2020
2021-01-17T21:16:08Z
bjbms:REV
driver
Differential diagnosis of hepatopulmonary syndrome (HPS): Portopulmonary hypertension (PPH) and hereditary hemorrhagic telangiectasia (HHT)
Krynytska, Inna
Marushchak, Mariya
Mikolenko, Anna
Bob, Anzhela
Smachylo, Iryna
Radetska, Ludmyla
Sopel, Olga
Hepatopulmonary syndrome
differential diagnosis
portopulmonary hypertension
hereditary hemorrhagic telangiectasia
PPH
HPS
HHT
orthotopic liver transplantation
OLT
Hepatopulmonary syndrome (HPS) is a severe complication of advanced liver disease associated with an extremely poor prognosis. HPS is diagnosed in 4-47% of patients with cirrhosis and in 15-20% of candidates for liver transplantation. In addition, severe hypoxia is associated with a high risk of complications of liver transplantation (a 30% chance during the first 90 days) and increases the gap between transplantation and improving arterial oxygenation. The pathogenesis of HPS is not fully understood, and no effective pharmacological treatment has been developed yet. Currently, the treatment of choice for HPS is orthotopic liver transplantation. Non-specific clinical criteria and the lack of standardized diagnostic criteria for determining HPS can lead to diagnostic errors. Portopulmonary hypertension and hereditary hemorrhagic telangiectasia, also known as Osler–Weber–Rendu syndrome, are pulmonary complications of liver disease which should be differentially diagnosed from HPS.
Association of Basic Medical Sciences of FBIH
2017-11-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2020
10.17305/bjbms.2017.2020
Biomolecules and Biomedicine; Vol. 17 No. 4 (2017); 276-285
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2020/360
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2020/1870
Copyright (c) 2017 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/2083
2021-01-05T19:26:23Z
bjbms:REV
driver
Craniosynostosis - Recognition, clinical characteristics, and treatment
Kajdic, Nina
Spazzapan, Peter
Velnar, Tomaz
Craniosynostosis
development
classification
diagnosis
treatment
Craniosynostosis is a developmental craniofacial anomaly, resulting in impairment of brain development and abnormally shaped skull. The main cause of craniosynostosis is premature closure of one or more cranial sutures. It usually occurs as an isolated condition, but may also be associated with other malformations as part of complex syndromes. When left untreated, craniosynostosis can cause serious complications, such as developmental delay, facial abnormality, sensory, respiratory and neurological dysfunction, anomalies affecting the eye, and psychological disturbances. Thus, early diagnosis, expert surgical techniques, postoperative care, and adequate follow-up are of vital importance in treating craniosynostosis.
Association of Basic Medical Sciences of FBIH
2018-05-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2083
10.17305/bjbms.2017.2083
Biomolecules and Biomedicine; Vol. 18 No. 2 (2018); 110-116
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2083/325
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2083/1824
Copyright (c) 2017 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/2201
2021-02-17T22:09:14Z
bjbms:REV
driver
Anesthesia for patients with mucopolysaccharidoses: Comprehensive review of the literature with emphasis on airway management
Clark, Brittney M.
Sprung, Juraj
Weingarten, Toby N.
Warner, Mary E.
General anesthesia
lysosomal storage diseases
tracheal intubation
laryngoscopy
Mucopolysaccharidoses (MPS) are rare, inherited, lysosomal storage diseases that cause accumulation of glycosaminoglycans, resulting in anatomic abnormalities and organ dysfunction that can increase the risk of anesthesia complications. We conducted a systematic review of the literature in order to describe the anesthetic management and perioperative outcomes in patients with MPS. We reviewed English-language literature search using an OVID-based search strategy of the following databases: 1) PubMed (1946-present), 2) Medline (1946-present), 3) EMBASE (1946-present), and 4) Web of Science (1946-present), using the following search terms: mucopolysaccharidosis, Hurler, Scheie, Sanfilippo, Morquio, Maroteaux, anesthesia, perioperative, intubation, respiratory insufficiency, and airway. The review of the literature revealed nine case series and 27 case reports. A substantial number of patients have facial and oral abnormalities posing various challenges for airway management, however, evolving new technologies that include videolaryngoscopy appears to substantially facilitate airway management in these patients. The only type of MPS that appears to have less difficulty with airway management are MPS III patients, as the primary site of glycosaminoglycan deposition is in the central nervous system. All other MPS types have facial and oral characteristics that increase the risk of airway management. To mitigate these risks, anesthesia should be conducted by experienced anesthesiologists with expertise in using of advanced airway intubating devices.
Association of Basic Medical Sciences of FBIH
2018-02-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2201
10.17305/bjbms.2017.2201
Biomolecules and Biomedicine; Vol. 18 No. 1 (2018); 1-7
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2201/322
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2201/1806
Copyright (c) 2017 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/2276
2021-01-05T19:27:26Z
bjbms:REV
driver
A plea for an extension of the anatomical nomenclature: The locomotor system
Musil, Vladimir
Blankova, Alzbeta
Baca, Vaclav
Anatomical terminology
anatomical nomenclature
Terminologia Anatomica
human locomotor system
Anatomical nomenclature is the main tool of communication in morphology, anatomy and other medical disciplines as well as in medical education, and thus needs to be exact, flawless, elaborate and correct. The Terminologia Anatomica (TA) is a thorough and extensive list of anatomical terms and their definitions, and the current standard for human anatomical terminology. Although several revisions to the TA have been made in the last 20 years, some important anatomical structures are still not included. This article is aimed at correcting and extending the anatomical nomenclature described in the TA. We gathered and presented a list of anatomical terms, with their definitions and explanations, to provoke a discussion about correcting and extending the TA. Our list comprises of 96 terms related to the locomotor system of the human body, i.e., the bones, joints, muscles and related structures.
Association of Basic Medical Sciences of FBIH
2018-05-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2276
10.17305/bjbms.2017.2276
Biomolecules and Biomedicine; Vol. 18 No. 2 (2018); 117-125
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2276/555
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2276/1825
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/2484
2021-06-06T21:27:29Z
bjbms:REV
driver
Gait disorder rehabilitation using vision and non-vision based sensors: A systematic review
Ali, Asraf
Sundaraj, Kenneth
Ahmad, Badlishah
Ahamed, Nizam
Islam, Anamul
Gait disorder
rehabilitation
sensor technology
Even though the amount of rehabilitation guidelines has never been greater, uncertainty continues to arise regarding the efficiency and effectiveness of the rehabilitation of gait disorders. This question has been hindered by the lack of information on accurate measurements of gait disorders. Thus, this article reviews the rehabilitation systems for gait disorder using vision and non-vision sensor technologies, as well as the combination of these. All papers published in the English language between 1990 and June, 2012 that had the phrases “gait disorder” “rehabilitation”, “vision sensor”, or “non vision sensor” in the title, abstract, or keywords were identified from the SpringerLink, ELSEVIER, PubMed, and IEEE databases. Some synonyms of these phrases and the logical words “and” “or” and “not” were also used in the article searching procedure. Out of the 91 published articles found, this review identified 84 articles that described the rehabilitation of gait disorders using different types of sensor technologies. This literature set presented strong evidence for the development of rehabilitation systems using a markerless vision-based sensor technology. We therefore believe that the information contained in this review paper will assist the progress of the development of rehabilitation systems for human gait disorders.
Association of Basic Medical Sciences of FBIH
2012-08-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2484
10.17305/bjbms.2012.2484
Biomolecules and Biomedicine; Vol. 12 No. 3 (2012); 193-202
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2484/438
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2484/2306
Copyright (c) 2017 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/2510
2021-06-06T20:59:40Z
bjbms:REV
driver
Clinical implications of cellular stress responses
Poljšak, Borut
Milisav, Irina
Cell stress
adaptive response
aging
transplantation
cancer
cardiovascular disease
Cellular stress response is a reaction to changes or fluctuations of extracellular conditions that damage the structure and function of macromolecules. Different stressors trigger different cellular responses, namely induce cell repair mechanisms, induce cell responses that result in temporary adaptation to some stressors, induce autophagy or trigger cell death. Inability to repair the damage or exposure to prolonged stress may contribute to aging. Persistent cell stress often enhances susceptibility to cancer and aging associated diseases. Cells and tissues are increasingly being used for transplantations and other novel therapeutic methods in which the quality and well being of cells is of paramount importance for the treatment to succeed. Therefore, discovering the mechanisms of cellular stress responses and the ability to detect and ameliorate them is important in prevention of development of disorders developed by persistent stress and for the success of transplantation and other cell related methods of regenerative medicine.
Association of Basic Medical Sciences of FBIH
2012-05-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2510
10.17305/bjbms.2012.2510
Biomolecules and Biomedicine; Vol. 12 No. 2 (2012); 122-126
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2510/454
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2510/2291
Copyright (c) 2017 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/2640
2020-03-04T12:07:08Z
bjbms:REV
driver
Non-matured arteriovenous fistulae for haemodialysis: diagnosis, endovascular and surgical treatment
Malovrh, Marko
haemodialysis
arteriovenous fi stula
vascular mapping
non-maturation
endovascular
Non-maturation is a feature of autologous vascular access. The autologous arteriovenous fistula needs time to mature and for the vein to enlarge to a size where it can be needled for dialysis. A fistula that fails early is one that either never develops adequately to support dialysis or fails within the first three months of its use. Two variables are required for fistula maturation. Firstly, the fistula should have adequate blood flow to support dialysis and secondly, it should have enough size to allow for successful repetitive cannulation. Three main reasons for maturation failure are: arterial and venous problems and the presence of accessory veins. Early diagnostics and intervention for fistula maturation minimizes catheter use and its associated complications. The identification of immature fistulae is relatively simple. Physical examination has been highlighted to be a valuable tool in assessing fistula. Any fistula that fails to mature adequately and demonstrates abnormal physical findings should be studied aggressively. Ultrasonography can successfully identify candidates who fail to meet the recently developed criteria for immature fistulae. In recent years, digital subtraction angiography and contrast-enhanced magnetic resonance angiography has been introduced for assessment of dysfunctional haemodialysis conduits, including immature fistulae. A great majority of non-matured fistulae can be successfully salvaged using percutaneous techniques. In addition to endovascular techniques, surgical intervention can also be an option. This paper reviews the process of fistula maturation and presents information regarding how to obtain a mature fistula.
Association of Basic Medical Sciences of FBIH
2010-04-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2640
10.17305/bjbms.2010.2640
Biomolecules and Biomedicine; Vol. 10 (2010): Suppl 1; S13-17
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2640/533
Copyright (c) 2017 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/2643
2020-03-04T12:08:52Z
bjbms:REV
driver
Kidney is in Trouble with Mediators
Balat, Ayse
adrenomedullin
children
glomerulonephritis
nephrotic syndrome
nitric oxide
urotensin-II
The kidneys receive 20-25 % of cardiac output and play a main role in the control of cardiovascular homeostasis. It is an endocrine organ that regulates and produces many substances, scavenger particles and immune complexes. Cytokines, growth factors, reactive oxygen metabolites, bioactive lipids, proteases, vasoactive substances such as nitric oxide (NO), adrenomedullin (AM), urotensin-II (U-II), have been released in several diseases, and kidney is one of mostly affected organs in body. Some of these mediators act in a paracrine fashion while some act in autocrine. They play important roles in modulating the cardiovascular responses, renal hemodynamics, and probably in mediating the clinical and laboratory manifestations of several renal diseases.
These mediators are like “a double edged sword.” While small amounts of them mediate many physiological events, little excess may cause the damage to the healthy cells. Many investigators have searched the role(s) of mediators in several diseases. However, the findings are mostly like the model of “chicken and egg”, and indistinguishable as to whether they are the causes of, or results of the diseases.
We will discuss mainly the possible roles of NO, AM and U-II in children with several renal diseases and summarize what is known, and what must be known about these mediators.
Association of Basic Medical Sciences of FBIH
2010-04-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2643
10.17305/bjbms.2010.2643
Biomolecules and Biomedicine; Vol. 10 (2010): Suppl 1; S29-36
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2643/536
Copyright (c) 2017 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/2655
2020-03-04T12:20:19Z
bjbms:REV
driver
Early Detection of Balkan Endemic Nephropathy in Bosanska Posavina
Mešić, Enisa
Balkan Endemic Nephropathy
diagnostic criteria
biomarkers
Balkan endemic nephropathy (BEN) is a chronic tubulointersticial nephropathy that is diagnosed in a few agrarian regions of Balkan. Even tough numerous dilemmas and conflicting opinions regarding BEN etiology are encountered in literature, prevailing theory is that BEN is caused by chronic poisoning with aristolochic acid ingested by food in people with genetic predisposition to this disease. BEN is categorized as a toxic tubulointerstitial nephropathy, with clinical picture and disease progression not differing from other tubulointerstitial nephropathies, but with insidious and gradual progression to end stage renal disease. There is no specific and sensitive diagnostic biomarkers for BEN and we use epidemiological and functional diagnostic criteria. It is considered that BEN affects up to 10% of population in endemic region. According to Renal Register of Bosnia and Herzegovina, there are around 15 % of BEN patients on chronic dialysis program, but no official data on the number of predialysis BEN patients, because of lack of adequate demographic data and screening or systematic examinations of the population living in the affected region since 1991. The members of the Society of nephrology, dialysis and transplantation of Bosnia and Herzegovina organized screening in two villages of Bosanska Posavina, as a part of the “Program Program of detection of chronic kidney diseases in high-risk population in Bosnia and Herzegovina, project which was approved from International Society of nephrology. In this paper we analyze preliminary results of that Program and discuss previous studies about BEN in Bosnia and Herzegovina, particularly diagnostic criteria and biomarkers of BEN.
Association of Basic Medical Sciences of FBIH
2010-04-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2655
10.17305/bjbms.2010.2655
Biomolecules and Biomedicine; Vol. 10 (2010): Suppl 1; S83-S90
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2655/548
Copyright (c) 2017 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/2683
2020-03-03T12:19:25Z
bjbms:REV
driver
The Mechanism of Protracted Wound Healing on Oral Mucosa in Diabetes. Review
Abiko, Yoshihiro
Selimovic, Denis
Diabetes
oral mucosa wound healing
Diabetic patients increase their body’s susceptibility to infection and diabetes is a risk factor for periodontal diseases and oral infection. Although many studies showed the mechanism of impaired wound healing in diabetes, there are still arguments to shed light on what kind of factors, including local and systemic factors are involved in the protracted wound healing. This review article summarizes reports on the wound healing in diabetes and discusses the mechanism of the protracted wound healing of the oral mucosa in diabetes. Delayed vascularization, reduction in blood flow, decline in innate immunity, decreases in growth factor production, and psychological stresses may be involved in the protracted wound healing of the oral mucosa in diabetics.
Association of Basic Medical Sciences of FBIH
2010-08-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2683
10.17305/bjbms.2010.2683
Biomolecules and Biomedicine; Vol. 10 No. 3 (2010); 186-191
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2683/566
Copyright (c) 2017 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/2684
2020-03-03T12:23:33Z
bjbms:REV
driver
Cyclooxygenase-2, P53 and Glucose Transporter-1 as Predictors of Malignancy in the Development of Gallbladder Carcinomas
Legan, Mateja
gallbladder carcinoma
cyclooxygenase-2
p53
glucose transporter-1
Gallbladder carcinoma is the fifth most common malignancy of the gastrointestinal tract. The absolute characteristics of the disease are the high mortality rate due to the late discovery of a tumor and the low therapeutic possibilities except by surgical intervention. In oncology we can predict the outcome of the disease with a combination of classical standard clinico/pathological parameters (stage of the tumors, differentiation) and the intrinsic genetic and biochemical properties of the tumor. Such intrinzic properties of the tumors that are connected with the outcome of the disease are the denominators (markers). The author searched extensively for the expression and influence of 3 markers included in chronic inflammation and early carcinogenesis, cell cycle regulation and tissue hypoxia: cyclooxygenase-2 (COX-2), p53 gene and glucose transporter-1 protein (GLUT-1). The author discusses their possible role in the development as well as fighting this disease, if specific medications targeting them were available
Association of Basic Medical Sciences of FBIH
2010-08-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2684
10.17305/bjbms.2010.2684
Biomolecules and Biomedicine; Vol. 10 No. 3 (2010); 192-196
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2684/567
Copyright (c) 2017 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/2702
2020-03-03T12:40:02Z
bjbms:REV
driver
The Automatic Regulation of the Basal Dose on the Insulin Pump for the Treatment of Patients that have Diabetes Type 1
Mehanović, Sifet
Mujić, Midhat
Diabetes mellitus type 1
glucose in the blood
insulin pump
basal dose
automatic regulation
Diabetes mellitus type 1 is a chronic metabolic disorder, and its main characteristic is Hyperglycemia. It usually occurs in the early years because of the absolute or relative absence of the active insulin that is caused by the autoimmune disease of the β cells of the pancreas. Despite the numerous researches and efforts of the scientists, the therapy for Diabetes type 1 is based on the substitution of insulin. Even though the principles of the therapy have not changed so much, still some important changes have occurred in the production and usage of insulin. Lately, the insulin pumps are more frequent in the therapy for Diabetes type 1. The functioning of the pump is based on the continuing delivery of insulin in a small dose (“the basal dose”), that keeps the level of glycemia in the blood constant. The increase of glycemia during the meal is reduced with the additional dose of insulin (“the bolus dose”). The use of the insulin pumps and the continuing glucose sensors has provided an easier and more efficient monitoring of the diabetes, a better metabolic control and a better life quality for the patient and his/her family.
This work presents the way of automatic regulation of the basal dose of insulin through the synthesis of the functions of the insulin pump and the continuing glucose sensor. The aim is to give a contribution to the development of the controlling algorithm on the insulin pump for the automatic regulation of the glucose concentration in the blood. This could be a step further which is closer to the delivery of the dose of insulin that is really needed for the basic needs of the organism, and a significant contribution is given to the development of the artificial pancreas.
Association of Basic Medical Sciences of FBIH
2010-05-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2702
10.17305/bjbms.2010.2702
Biomolecules and Biomedicine; Vol. 10 No. 2 (2010); 100-106
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2702/583
Copyright (c) 2017 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/2747
2020-03-09T13:08:55Z
bjbms:REV
driver
Immunomodulatory Compounds (Imids®) in the Treatment of Multiple Myeloma
Srkalovic, Gordan
Hussein, Mohamad
lenalidomide
thalidomide
multiple myeloma
pomalidomide
IMiDs®
The design of innovative, more effective, less toxic therapy of multiple myeloma (MM) is emerging in parallel to a better understanding of the underlying pathophysiology of this common hematologic malignancy. Thalidomide has changed the treatment paradigm of patients with MM. Its efficacy, however, has been compromised by significant side effects. IMiDs® (immunodulatory compounds) are structural and functional analogs of thalidomide that were specifically designed to create new agents with enhanced immunomodulatory and anticancer properties and better tolerability profiles. In this article, we review the clinical trial development of the second-generation IMiDs®, lenalidomide and pomalidomide. Both agents demonstrate potent activity and are highly effective and well tolerated treatment options for patients with MM.
Association of Basic Medical Sciences of FBIH
2009-10-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2747
10.17305/bjbms.2009.2747
Biomolecules and Biomedicine; Vol. 9 No. 1 (2009): Suppl 1; S3-S10
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2747/614
Copyright (c) 2017 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/2748
2020-03-09T13:09:48Z
bjbms:REV
driver
Towards Individualized Medicine: Insights Gained from Genomic Studies
Kirmani, Salman
Babovic-Vuksanovic, Dusica
personalized medicine
genome-wide association studies
single nucleotide polymorphism
Advances in the field of human genetics have made it possible to develop specific management and prevention strategies for rare genetic disorders, and tailor pharmacotherapeutic approaches to anticoagulation and certain cancers. The role that genetic variation plays in influencing the risk and outcome of the most common diseases are still unclear. Data from genome-wide association studies is just beginning to answer these questions. We review the role of genome-wide association studies in the quest towards individualized medicine, and examine the promises and challenges that lie ahead.
Association of Basic Medical Sciences of FBIH
2009-10-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2748
10.17305/bjbms.2009.2748
Biomolecules and Biomedicine; Vol. 9 No. 1 (2009): Suppl 1; S11-S16
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2748/615
Copyright (c) 2017 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/2749
2020-03-09T13:11:44Z
bjbms:REV
driver
Clinical Significance of the KRAS Mutation
Beganovic, Sead
KRAS mutation
prognostic biomarker
selection marker
The challenge of translational medicine is to translate very complex scientific data into the clinical setting so that medical management can be better guided towards the ultimate goal of better patient outcome. Physicians now have the opportunity to use specific biomarkers to personalize therapeutic options in various settings. Recent research has demonstrated that presence of Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation may directly influence medical decisions in patients with colon and lung cancer.
Use of KRAS oncogene as a selection marker for specific treatment is a good example of individualized medicine approach to cancer treatment.
Association of Basic Medical Sciences of FBIH
2010-10-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2749
10.17305/bjbms.2009.2749
Biomolecules and Biomedicine; Vol. 9 No. 1 (2009): Suppl 1; S17-S20
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2749/616
Copyright (c) 2017 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/2750
2020-03-09T13:12:44Z
bjbms:REV
driver
Red Blood Cell Storage Lesion
Kor, Daryl J.
Van Buskirk, Camille M
Gajic, Ognjen
red blood cell transfusion
storage lesion
transfusion effiacacy
transfusion risks
The past two decades have witnessed increased scrutiny regarding efficacy and risk of the once unquestioned therapy of red blood cell (RBC) transfusion. Simultaneously, a variety of changes have been identified within the RBC and storage media during RBC preservation that are correlated with reduced tissue oxygenation and transfusion-associated adverse effects. These alterations are collectively termed the storage lesion and include extensive biochemical, biomechanical, and immunologic changes involving cells of diverse origin. Time-dependent falls is 2,3-diphosphoglycerate, intracellular RBC adenosine triphosphate, and nitric oxide have been shown to impact RBC deformability and delivery of oxygen to the end-organ. The accumulation of biologic response modifiers such as soluble CD40 ligand (sCD40L), lysophosphatidylcholine (lyso-PC), and Regulated on Activation, Normal T-cell Expressed and Secreted (RANTES) have been associated with altered recipient immune function as well. This review will address the alterations occurring within the RBC and storage media during RBC preservation and will address the potential clinical consequence thereof.
Association of Basic Medical Sciences of FBIH
2009-10-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2750
10.17305/bjbms.2009.2750
Biomolecules and Biomedicine; Vol. 9 No. 1 (2009): Suppl 1; S21-S27
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2750/617
Copyright (c) 2017 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/2751
2020-03-09T13:13:52Z
bjbms:REV
driver
Thigh Compartment Syndrome, Presentation and Complications
G. Verwiebe, Eric
M. Kanlic, Enes
Saller, Jeremy
Abdelgawad, Amr
thigh injuries
compartment syndrome
amputation
renal insufficiency
To describe the patient population, etiology, and complications associated with thigh compartment syndrome (TCS). TCS is a rare (0.3% of trauma patients) condition of elevated pressure within a constrained space that may cause necrosis of all tissues within the compartment resulting in severe local (infection, amputation) and systemic complications (renal insufficiency, even death). Retrospective cohort This study examines the course of treatment of nine consecutive patients with thigh compartment syndrome sustained during an eight-year period at our Level 1 trauma centre, admitting more than 2,000 trauma patients yearly.
Patients developing TCS were young (average 34.8 years) and likely to have a vascular injury on presentation (55.5%). A tense and edematous thigh was the most consistent clinical exam finding prompting the compartment release (77.8%). Average time from admission to the operating room was 19.8 ± 6 hours and 3/9 (33%) were noted to have ischemic muscle changes upon compartment releases. Complications ranging from infection to amputation developed in 4/9 (44.4%) patients.
TCS is associated with high energy trauma and it is difficult to diagnose in non-cooperative - obtunded and polytrauma patients. Vascular injuries are a common underlying cause and require prompt recognition and team work including surgical intensive care, interventional radiology, vascular and orthopaedic surgery in order to avoid severe medical and legal consequences.
Association of Basic Medical Sciences of FBIH
2009-09-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2751
10.17305/bjbms.2009.2751
Biomolecules and Biomedicine; Vol. 9 No. 1 (2009): Suppl 1; S28-S33
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2751/618
Copyright (c) 2017 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/2752
2020-03-09T13:14:55Z
bjbms:REV
driver
Medical Informatics: An Essential Tool for Health Sciences Research in Acute Care
Li, Man
W. Pickering, Brian
D. Smith, Vernon
Hadzikadic, Mirsad
Gajic, Ognjen
Herasevich, Vitaly
ICU
EMR
DataMart
alarm
dashboard
modeling
Medical Informatics has become an important tool in modern health care practice and research. In the present article we outline the challenges and opportunities associated with the implementation of electronic medical records (EMR) in complex environments such as intensive care units (ICU). We share our initial experience in the design, maintenance and application of a customized critical care, Microsoft SQL based, research warehouse, ICU DataMart. ICU DataMart integrates clinical and administrative data from heterogeneous sources within the EMR to support research and practice improvement in the ICUs. Examples of intelligent alarms – “sniffers”, administrative reports, decision support and clinical research applications are presented.
Association of Basic Medical Sciences of FBIH
2009-10-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2752
10.17305/bjbms.2009.2752
Biomolecules and Biomedicine; Vol. 9 No. 1 (2009): Suppl 1; S34-S39
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2752/619
Copyright (c) 2017 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/2755
2020-06-21T23:23:02Z
bjbms:REV
driver
Extramedullary Intradural Spinal Tumors: a Review of Modern Diagnostic and Treatment Options and a Report of a Series
Arnautovic, Kenan
Arnautovic, Aska
spine
spinal cord
tumors
intradural
extramedullary
meningiomas
Schwannomas
ependymomas
Extramedullary intradural spinal tumors are rare. Less than 15% of all central nervous system (CNS) tumors are spinal. Ninety percent of these patients are older than 20 years. Most of spinal tumors are extradural (50-55%) whereas 40-45% are intradural. Furthermore, 5% are intramedullary and 40% are extramedullary. Most common are Schwannomas (29%), followed by meningiomas (25%) and gliomas (22%).
These tumors produce pain syndroms, a variety of neurological symptoms- motor, sensory, sphincter or a combination of thereof. All spinal levels may be involved. The diagnostics includes magnetic resonance imaging (MRI) including contrast enhancement, computerizing tomography (CT) scanning (bone windows with reconstruction) and possibly CT myelograms. Preferred treatment is the microsurgical radical resection. Perioperative mortality is very low as is serious morbidity.
We herein discuss various aspects of presenting symptomatology, diagnostics, preoperative planning and tactics, surgical treatment and complications. In addition, we include our own retrospective experience with 14 patients treated over the 5.5 years time interval.
Association of Basic Medical Sciences of FBIH
2009-10-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2755
10.17305/bjbms.2009.2755
Biomolecules and Biomedicine; Vol. 9 No. 1 (2009): Suppl 1; S40-S45
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2755/620
Copyright (c) 2017 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/2756
2021-01-05T18:38:20Z
bjbms:REV
driver
The role of the Hedgehog signaling pathway in cancer: A comprehensive review
Skoda, Ana Marija
Simovic, Dora
Karin, Valentina
Kardum, Vedran
Vranic, Semir
Serman, Ljiljana
Hedgehog signaling pathway
Hh
tumorigenesis
signal transduction
The Hedgehog (Hh) signaling pathway was first identified in the common fruit fly. It is a highly conserved evolutionary pathway of signal transmission from the cell membrane to the nucleus. The Hh signaling pathway plays an important role in the embryonic development. It exerts its biological effects through a signaling cascade that culminates in a change of balance between activator and repressor forms of glioma-associated oncogene (Gli) transcription factors. The components of the Hh signaling pathway involved in the signaling transfer to the Gli transcription factors include Hedgehog ligands (Sonic Hh [SHh], Indian Hh [IHh], and Desert Hh [DHh]), Patched receptor (Ptch1, Ptch2), Smoothened receptor (Smo), Suppressor of fused homolog (Sufu), kinesin protein Kif7, protein kinase A (PKA), and cyclic adenosine monophosphate (cAMP). The activator form of Gli travels to the nucleus and stimulates the transcription of the target genes by binding to their promoters. The main target genes of the Hh signaling pathway are PTCH1, PTCH2, and GLI1. Deregulation of the Hh signaling pathway is associated with developmental anomalies and cancer, including Gorlin syndrome, and sporadic cancers, such as basal cell carcinoma, medulloblastoma, pancreatic, breast, colon, ovarian, and small-cell lung carcinomas. The aberrant activation of the Hh signaling pathway is caused by mutations in the related genes (ligand-independent signaling) or by the excessive expression of the Hh signaling molecules (ligand-dependent signaling – autocrine or paracrine). Several Hh signaling pathway inhibitors, such as vismodegib and sonidegib, have been developed for cancer treatment. These drugs are regarded as promising cancer therapies, especially for patients with refractory/advanced cancers.
Association of Basic Medical Sciences of FBIH
2018-02-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2756
10.17305/bjbms.2018.2756
Biomolecules and Biomedicine; Vol. 18 No. 1 (2018); 8-20
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2756/684
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2756/1807
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/2762
2020-03-09T13:17:13Z
bjbms:REV
driver
Current prophylactic perioperative antibiotic guidelines in trauma: a review of the literature and outcome data
Hadzikadic, Lejla
guidelines
prophylactic antibiotic use in trauma
data from the past 32 years
define standards of care
A comprehensive review of prophylactic use of perioperative antibiotics in trauma from the 1970s to the present was performed. Evidence based guidelines were used to analyze the data from the past 32 years and define standards of care in the field. Recommendations and suggestions are provided to offer guidelines for prophylactic antibiotic use in trauma. Highlighted topics include general trauma surgery, with focus placed on abdominal and thoracic surgery in trauma, and non-trauma surgery, including subspecialties, for comparison.
Association of Basic Medical Sciences of FBIH
2009-10-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2762
10.17305/bjbms.2009.2762
Biomolecules and Biomedicine; Vol. 9 No. 1 (2009): Suppl 1; S46-S53
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2762/621
Copyright (c) 2017 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/2763
2020-03-09T13:18:56Z
bjbms:REV
driver
When Less is More in the Intensive Care Unit
Festic, Emir
Gajic, Ognjen
Intensive care
evidence-based
first do no harm
In parallel to technological advances in late twentieth century, medical diagnostics and therapeutic options greatly improved. A surge of evidence-based research in intensive care medicine provided additional opportunities and the “best” medical practice has been changing rapidly. However, the primary focus of Hippocrates: “Primum non nocere” (first do no harm) is often neglected at the bedside. It became apparent that lesser intervention in the ICU may actually mean more for the patient. Multiple examples of the concept “when less is more in the ICU” are described here in an ABC format. Critical care providers have an obligation to keenly and closely follow the results of new investigative studies and to carefully incorporate those into our practice. However, they have to be sensitive to individual circumstances, patient and family preferences, and avoidance of harm.
Association of Basic Medical Sciences of FBIH
2009-10-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2763
10.17305/bjbms.2009.2763
Biomolecules and Biomedicine; Vol. 9 No. 1 (2009): Suppl 1; S54-S58
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2763/622
Copyright (c) 2017 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/2764
2020-03-09T13:19:45Z
bjbms:REV
driver
Acute Respiratory Distress Syndrome: Insights Gained from Clinical and Translational Research
Kojicic, Marija
Festic, Emir
Gajic, Ognjen
Respiratory distress syndrome
adult
mechanical ventilation
pulmonary edema
Acute lung injury and its more severe form acute respiratory distress syndrome (ARDS) are characterized by diffuse impairment of alveolocapillary membrane in the settings of different predisposing conditions such as sepsis, trauma and shock. Many intrahospital exposures, including aspiration, delayed resuscitation, high tidal volume mechanical ventilation and non critical use of transfusions may contribute or worsen ARDS. Therapy is targeted to treatment of predisposing condition, life supportive measures and prevention of nosocomial complications. Rigorous adherence to lung-protective mechanical ventilation is critical to prevent ventilator induced lung injury and decrease mortality. Although survival of ARDS patients has improved in the last decades ARDS mortality rates are still high and survivors encounter significant physical and psychological impairments
Association of Basic Medical Sciences of FBIH
2009-10-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2764
10.17305/bjbms.2009.2764
Biomolecules and Biomedicine; Vol. 9 No. 1 (2009): Suppl 1; S59-S68
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2764/623
Copyright (c) 2017 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/2766
2020-03-09T13:20:57Z
bjbms:REV
driver
From Mechanical Ventilation to Intensive Care Medicine: A Challenge for Bosnia and Herzegovina
Thiéry, Guillaume
Kovačević, Pedja
Štraus, Slavenka
Vidović, Jadranka
Iglica, Amer
Festić, Emir
Gajić, Ognjen
intensive care
mechanical ventilation
critical care
non invasive ventilation
developing countries
Intensive care medicine is a relatively new specialty, which was created in the 1950's, after invent of mechanical ventilation, which allowed caring for critically ill patients who otherwise would have died. First created for treating mechanically ventilated patients, ICUs extended their scope and care to all patients with life threatening conditions. Over the years, intensive care medicine developed further and became a truly multidisciplinary speciality, encompassing patients from various fields of medicine and involving specialists from a range of base specialties, with additional (subspecialty) training in intensive care medicine. In Bosnia and Herzegovina, the founding of the society of intensive care medicine in 2006, the introduction of non invasive ventilation in 2007, and opening of a multidisciplinary ICUs in Banja Luka and Sarajevo heralded a new age of intensive care medicine. The number of admissions, high severity scores and needs for mechanical ventilation during the first several months in the medical ICU in Banja Luka confirmed the need of these kinds of units in the country. In spite of still suboptimal personnel training, creation of ICUs in Bosnia and Herzegovina may serve as example for other developing countries in the region. However, in order to achieve modern ICU standards and follow European trends toward harmonisation of medicine, Bosnia and Herzegovina needs to take up this challenge by recognizing intensive care medicine as a distinctive specialty, by implementing a specific training program and by setting up multidisciplinary ICUs in acute care hospitals.
Association of Basic Medical Sciences of FBIH
2009-10-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2766
10.17305/bjbms.2009.2766
Biomolecules and Biomedicine; Vol. 9 No. 1 (2009): Suppl 1; S69-S76
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2766/624
Copyright (c) 2017 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/2767
2020-03-09T13:22:24Z
bjbms:REV
driver
Evaluation of the Intrinsic Properties of Pedicle Screws: Do Diameter, Manufacturing and Screw Design Affect Resistance and/or Resistivity
Limthongkul, Worawat
Savage, Jason
K. Nenonene, Emmanuel
E. Karaikovic, Eldin
pedicle screw
electrical resistance
electrical resistivity
intraoperative neuromonitoring
The pedicle screw diameter, composite and design are variables that can affect the threshold of intraoperative electromyographic monitoring. Even though we know that larger diameter objects tend to have less resistance, no study documented the effect that this variable could have on pedicle screw resistance. Using high quality equipment, resistance and resistivity of ten pedicle screws (from four manufacturers) were calculated based on known constant current and measured voltage. Voltage was measured three times for each screw to determine intraobserver measurement variability. Resistance of all screws ranged from 1.4 to 3.9 m ohm (mean = 2.69+/-0.71 m ohm). The screw with largest diameter (7.75 mm) had lower resistance than screws with other diameters. Resistivity of screws ranged from 7.12 to 12.63 micro ohm*m (mean = 9.9+/-1.82 micro ohm*m). Based on the screw design, one manufacturer's pedicle screws (A) had significantly lower resistivity compared to three other manufacturers (p<0.01). Larger diameter screws (7.75 mm in diameter) had lower resistance. Screw design (polyaxial or monoaxial) had no effect on its resistance. Screws of one manufacturer (A) showed lower resistivity compared to those manufactured by other three companies.
Association of Basic Medical Sciences of FBIH
2009-10-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2767
10.17305/bjbms.2009.2767
Biomolecules and Biomedicine; Vol. 9 No. 1 (2009): Suppl 1; S77-S82
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2767/625
Copyright (c) 2017 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/2768
2020-03-09T13:23:32Z
bjbms:REV
driver
Depression in Adolescents: Current Treatments, Suicidality and Evaluation of Novel Treatment Strategies
Smajkic, Amer
Depression
adolescents
novel treatment strategies
Multiple studies have examined the age of onset of major depression, indicating it is most frequent in adolescence and young adulthood. In this context, the offspring of depressed parents have a 2 to 4 time increased risk for depression compared with children of non-depressed parents.Treatment for depression in adolescents can be divided into psychosocial, psychopharmacologic, somatic and combined psychosocial-psychopharmacologic, psychosocial-psychosomatic and psychopharmacologic-psychosomatic.Depression in the children and adolescent population has been an area of research for over 20 years. Among novel therapeutic strategies, transcranial magnetic stimulation (TMS) has demonstrated the most favorable side effect profile. Until this time there are no published suicide attempts associated with this treatment and it may offer an option that is not associated with stigma of electroconvulsive therapy (ECT) or medications. Further research may provide more access to this therapy and hope to children, adolescents with depression and their families.
Association of Basic Medical Sciences of FBIH
2009-10-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2768
10.17305/bjbms.2009.2768
Biomolecules and Biomedicine; Vol. 9 No. 1 (2009): Suppl 1; S83-S88
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2768/626
Copyright (c) 2017 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/2792
2021-01-09T13:47:21Z
bjbms:REV
driver
Therapeutic role of methotrexate in pediatric Crohn’s disease
Djurić, Zlatko
Šaranac, Ljiljana
Budić, Ivana
Pavlović, Voja
Djordjević, Jelena
Methotrexate
Crohn’s disease
children
therapy
MTX
thiopurines
immunomodulator
remission
The main role of therapy in Crohn’s disease (CD) is to achieve long-term clinical remission, and to allow for normal growth and development of children. The immunomodulatory drugs used for the maintenance of remission in CD include thiopurines (azathioprine and 6-mercaptopurine) and methotrexate (MTX). Development of hepatosplenic T-cell lymphoma in some patients with inflammatory bowel disease, treated with thiopurines only or in combination with anti-tumor necrosis factor agents, resulted in a growing interest in the therapeutic application of MTX in children suffering from CD. This review summarizes the literature on the therapeutic role of MTX in children with CD. MTX is often administered as a second-line immunomodulator, and 1-year clinical remission was reported in 25–69% of children with CD after excluding for the use of thiopurines. Initial data on MTX effectiveness in mucosal healing, and as a first-line immunomodulator in pediatric patients with CD, are promising. A definite conclusion, however, may only be made on the basis of additional research with a larger number of subjects.
Association of Basic Medical Sciences of FBIH
2018-08-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2792
10.17305/bjbms.2018.2792
Biomolecules and Biomedicine; Vol. 18 No. 3 (2018); 211-216
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2792/755
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2792/1838
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/2863
2020-03-09T12:46:29Z
bjbms:REV
driver
Primary Open-Angle Glaucoma and Serum Lipids
Pavljašević, Suzana
Ašćerić, Mensura
serum lipids
primary open-angle glaucoma
cholesterol
triglyceride
The aim of this paper was to prove the relation between serum lipid values (cholesterol, trig- lyceride, low density cholesterol, high density cholesterol and primary open -angle glaucoma. The study includes two patient groups: 50 patients with primary open-angle glaucoma and 50 patients without this disease. However, all 100 patients were tested for serum lipid values. The research covered a period of six months (from May to December 2007.). Primary open-angle glaucoma was diagnosed with intraocular pressure values (between 20,1 and 25,6 mm Hg) measured with Schiotz tonometry. The visual field changes were confirmed with Goldmann perimetry. The gonioscopies were done for diagnosis confirmation. The serum lipid values were confirmed with enzymatic colorimetry in vitro method. U-test (Mann-Witney-Wilcox test) and t-test, as nonparametric tests, were used for statistical evaluations. The cholesterol mean value in the test group was 6,14 mol/dm1 (3,20-8,10 mol/dm3) whereas in the control group it was 5,96 mol/dm3 (2,70-8,80 mol/dm3). U-test was with negative ranks (z=-0,83 AS=0,678). The triglyceride mean value in the test group was 2,38 mol/dm3 (0,84-11,73 mol/m3) and in the control group it was 2,04 mol/dm3 (0,63-5,89 mol/dm3). U-test was with positive ranks (z=0,950 AS=0,342). High density cholesterol was average in the test group with 1,45 mol/dm3 (0,71-3,40 mol/dm3) and in the control group 1,40 mol/m3 (0,80-3,20 mol/dm3). Low density cholesterol in the test group was 3,98 mol/m3 (1,82-6,49 mol/m3) and in the control group 4,08 mol/m3 (2,69-5,69 mol/m3). These results had positive ranks according to U-test. Serum lipid values could be one of predictable factors in primary open-angle glaucoma diagnosis. Due to the patient age, cholesterol values, as common factors in primary open-angle glaucoma and atherosclerosis genesis, could be concern in the same aetiology based on dyslipidaemia as well.
Association of Basic Medical Sciences of FBIH
2009-02-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2863
10.17305/bjbms.2009.2863
Biomolecules and Biomedicine; Vol. 9 No. 1 (2009); 85-88
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2863/682
Copyright (c) 2017 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/2864
2020-03-09T12:47:58Z
bjbms:REV
driver
Influence of Type and Neutralisation Capacity of Antacids on Dissolution Rate of Ciprofloxacin and Moxifloxacin from Tablets
Uzunović, Alija
Vranić, Edina
dissolution
neutralization capacity
ciprofloxacin
moxifloxacin
antacid
interaction
Dissolution rate of two fluoroquinolone antibiotics (ciprofloxacin and moxifloxacin) was analysed in presence/absence of three antacid formulations. Disintegration time and neutralisation capacity of antacid tablets were also checked. Variation in disintegration time indicated the importance of this parameter, and allowed evaluation of the influence of postponed antacid-fluoroquinolone contact. The results obtained in this study showed decreased dissolution rate of fluoroquinolone antibiotics from tablets in simultaneous presence of antacids, regardless of their type and neutralisation capacity.
Association of Basic Medical Sciences of FBIH
2009-02-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2864
10.17305/bjbms.2009.2864
Biomolecules and Biomedicine; Vol. 9 No. 1 (2009); 89-93
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2864/683
Copyright (c) 2017 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/2975
2020-03-10T11:14:24Z
bjbms:REV
driver
Polymorphism in Methylentetrahydrofolate Reductase Gene: Important Role in Diseases
Kiseljaković, Emina
Jadrić, Radivoj
Hasić, Sabaheta
Skenderi, Faruk
Resić, Halima
Winterhalter-Jadrić, Mira
MTHFR
Homocysteine
polymorphism diseases
It has been recognized that some people have a genetic variant which leads to elevated levels of homocysteine and impairs ability to process folate. This condition was recognized as independent risk factor of coronary heart disease. Recently, connection between this termolabile mutation of the methylenetetrahydrofolate reductase and numerous conditions and diseases has been established. Aim of this review is to draw attention to this interesting area in medicine. Additionally, well defined study about presence and frequency of gene polymorphism in our region will provide proper diagnosis and achieve possible delay of development of diseases with vitamin supplementation.
Association of Basic Medical Sciences of FBIH
2008-05-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2975
10.17305/bjbms.2008.2975
Biomolecules and Biomedicine; Vol. 8 No. 2 (2008); 165-169
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/2975/733
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3000
2020-03-12T12:57:10Z
bjbms:REV
driver
Scanning Near-Field Optical Microscopy
Vobornik, Dušan
Vobornik, Slavenka
microscopy
optical microscopy
resolution
scanning
An average human eye can see details down to 0,07 mm in size. The ability to see smaller details of the matter is correlated with the development of the science and the comprehension of the nature. Today’s science needs eyes for the nano-world. Examples are easily found in biology and medical sciences. There is a great need to determine shape, size, chemical composition, molecular structure and dynamic properties of nano-structures. To do this, microscopes with high spatial, spectral and temporal resolution are required. Scanning Near-field Optical Microscopy (SNOM) is a new step in the evolution of microscopy. The conventional, lens-based microscopes have their resolution limited by diffraction. SNOM is not subject to this limitation and can offer up to 70 times better resolution.
Association of Basic Medical Sciences of FBIH
2008-02-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3000
10.17305/bjbms.2008.3000
Biomolecules and Biomedicine; Vol. 8 No. 1 (2008); 63-71
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3000/749
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3133
2021-01-09T13:49:21Z
bjbms:REV
driver
Clinical features and management of oral lichen planus (OLP) with emphasis on the management of hepatitis C virus (HCV)-related OLP
Mester, Alexandru
Lucaciu, Ondine
Ciobanu, Lidia
Apostu, Dragos
Ilea, Aranka
Campian, Radu Septimiu
Oral lichen planus
OLP
hepatitis C virus infection
HCV
management of oral pathology
direct acting antivirals
DAA
Oral lichen planus (OLP) is a chronic inflammatory disease characterized by the occurrence of multiple, symmetrical lesions in the oral cavity. Hepatitis C virus (HCV) infection has been suggested as an etiological factor in OLP. The purpose of this review was to summarize the current literature regarding the treatment of OLP in patients with HCV infection. An electronic search of the PubMed database was conducted until January 2018, using the following keywords: OLP, HCV, corticosteroids, retinoids, immunomodulatory agents, surgical interventions, photochemotherapy, laser therapy, interferon, ribavirin, and direct-acting antivirals. We selected the articles focusing on the clinical features and treatment management of OLP in patients with/without HCV infection. Topical corticosteroids are considered the first-line treatment in OLP. Calcineurin inhibitors or retinoids can be beneficial for recalcitrant OLP lesions. Systemic therapy should be used in the case of extensive and refractory lesions that involve extraoral sites. Surgical intervention is recommended for isolated lesions. In patients with HCV, monotherapy with interferon (IFN)-α may either improve, aggravate or trigger OLP lesions, while combined IFN-α and ribavirin therapy does not significantly influence the progression of lesions. Direct-acting antiviral (DAA) therapy appears to be a promising approach in patients with HCV-related OLP, as it can improve symptoms of both liver disease and OLP, with fewer side effects. Nevertheless, for clinical utility of DAAs in OLP patients, further studies with larger sample sizes, adequate treatment duration, and long term follow-up are required.
Association of Basic Medical Sciences of FBIH
2018-08-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3133
10.17305/bjbms.2018.3133
Biomolecules and Biomedicine; Vol. 18 No. 3 (2018); 217-223
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3133/1107
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3133/1839
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3143
2020-07-24T09:31:48Z
bjbms:REV
driver
Immunosuppressive Therapy Protocols in Kidney Transplantation in Adults
Karamehić, Jasenko
Lorber, Marc
Formica, Richard
Gavrankapetanović, Faris
Heljić, Bećir
Subašić, Đemo
Zečević, Lamija
drug
immunosuppression
kidney transplant
In practical terms, regardless of HLA compatibility level, whenever tissues are transplanted from one person to another it is essential to suppress the immune response of the recipient. A variety of methods are available however, the most frequently used ones have the disadvantage of being immunologicaly non specific. The consequence is a difficult balance between immunosuppression sufficient to prevent the tissue rejection and maintenance of immune system at the level of ability to adequately deal with an infection. The goal, not yet achieved, is to find a way of generating donor specific immunosuppression that leaves the immune machinery otherwise completely intact. The major approaches to immunosuppression are described below.
Association of Basic Medical Sciences of FBIH
2006-08-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3143
10.17305/bjbms.2006.3143
Biomolecules and Biomedicine; Vol. 6 No. 3 (2006); 43-47
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3143/853
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3151
2020-07-24T09:32:47Z
bjbms:REV
driver
Osteoarthritis, Application of Physical Therapy Procedures
Avdić, Dijana
Pecar, Džemal
Mujić-Skikić, Emela
Pecar, Ehlimana
osteoarthritis
functional treatment
physical therapy procedures
Osteoarthritis (OA) is a group of overlapping disorders, which may have different aetiology but similar biological, morphologic and clinical outcome. In osteoarthritis, process will not encompass the joint cartilage only, but the entire joint, including sub-hondral bone, ligaments, capsule, and sinovial membrane and surrounding muscles. Osteoarthritis is a multi-factor disorder of sinovial joints, which occurs as result of mechanical and biological factors, which destabilise normal hondrocyte function, partitioning of cartilage, extra-cellular matrix and sub-hondral bone. The earliest changes, which are restricted to the joint cartilage surface only, do not cause any subjective feeling. The pain in arthrosis occurs (or re-occurs) a bit later, Diagnosis will be determined based on clinical exam as well as signs and symptoms present. Symptomatic and functional treatment of osteoarthritis as one of rheumatic disorders must be taken throughout years, sometimes throughout a lifetime. It encompasses application of many medications and physical therapy procedures.
Association of Basic Medical Sciences of FBIH
2008-08-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3151
10.17305/bjbms.2006.3151
Biomolecules and Biomedicine; Vol. 6 No. 3 (2006); 84-88
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3151/861
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3195
2020-12-27T09:30:45Z
bjbms:REV
driver
A plea for an extension of the anatomical nomenclature: Organ systems
Musil, Vladimir
Blankova, Alzbeta
Dvorakova, Vlasta
Turyna, Radovan
Baca, Vaclav
Anatomical terminology
anatomical nomenclature
Terminologia Anatomica
This article is the third part of a series aimed at correcting and extending the anatomical nomenclature. Communication in clinical medicine as well as in medical education is extensively composed of anatomical, histological, and embryological terms. Thus, to avoid any confusion, it is essential to have a concise, exact, perfect and correct anatomical nomenclature. The Terminologia Anatomica (TA) was published 20 years ago and during this period several revisions have been made. Nevertheless, some important anatomical structures are still not included in the nomenclature. Here we list a collection of 156 defined and explained technical terms related to the anatomical structures of the human body focusing on the digestive, respiratory, urinary and genital systems. These terms are set for discussion to be added into the new version of the TA.
Association of Basic Medical Sciences of FBIH
2019-02-12
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3195
10.17305/bjbms.2018.3195
Biomolecules and Biomedicine; Vol. 19 No. 1 (2019); 1-13
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3195/1114
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3195/1760
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3202
2020-06-21T00:53:32Z
bjbms:REV
driver
Computer Assisted Orthopaedic Surgery – CAOS
M. Kanlić, Enes
DeLaRosa, Fabian
Pirela-Cruz, Miguel
CAOS
Computer Assisted Orthopaedic Surgery
orthopedics
surgery
The use of computer navigation in orthopedic surgery allows for real time intraoperative feedback resulting in higher precision of bone cuts, better alignment of implants and extremities, easier fracture reductions, less radiation and better documentation than what is possible in classical orthopaedic procedures. There is no need for direct and repeated visualization of many anatomical landmarks (classical method) in order to have good intraoperative orientation. Navigation technology depicts anatomy and position of "smart tools" on the screen allowing for high surgical precision (smaller number of outliers from desired goal) and with less soft tissue dissection (minimally invasive surgery - MIS). As a result, there are more happy patients with less pain, faster recovery, better functional outcome and well positioned, long lasting implants. In general, navigation cases are longer on the average 10 to 20 minutes, special training is required and equipment is relatively expensive. CAOS applications in knee and hip joint replacement are discussed.
Association of Basic Medical Sciences of FBIH
2006-02-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3202
10.17305/bjbms.2006.3202
Biomolecules and Biomedicine; Vol. 6 No. 1 (2006); 7-14
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3202/881
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3203
2020-07-27T08:51:40Z
bjbms:REV
driver
Brucella Melitensis Review of the Human Infection Case
Zvizdić, Šukrija
Čengić, Dževad
Bratić, Maja
Mehanić, Snježana
Pinjo, Fikret
Hamzić, Sadeta
Brucellosis
Prosthetic joint infection
Returning traveller
Travel medicine
Brucella spp. prosthetic joint infections are infrequently reported in the literature, particularly in returning travellers, and optimal treatment is unknown.
METHOD:
We describe a prosthetic joint infection (PJI) caused by Brucella melitensis in a traveller returning to the UK from Thailand, which we believe to be the first detailed report of brucellosis in a traveller returning from this area. The 23 patients with Brucella-related PJI reported in the literature are summarised, together with our case.
RESULTS:
The diagnosis of Brucella-related PJI is difficult to make; only 30% of blood cultures and 75% of joint aspiration cultures were positive in the reported cases. Culture of intraoperative samples provides the best diagnostic yield. In the absence of radiological evidence of joint loosening, combination antimicrobial therapy alone may be appropriate treatment in the first instance; this was successful in 6/7 [86%] of patients, though small numbers of patients and the likelihood of reporting bias warrant caution in drawing any firm conclusions about optimal treatment. Aerosolisation of synovial fluid during joint aspiration procedures and nosocomial infection has been described.
CONCLUSIONS:
Brucella-related PJI should be considered in the differential of travellers returning from endemic areas with PJI, including Thailand. Personal protective equipment including fit tested filtering face piece-3 (FFP3) mask or equivalent is recommended for personnel carrying out joint aspiration when brucellosis is suspected. Travellers can reduce the risk of brucellosis by avoiding unpasteurised dairy products and animal contact (particularly on farms and abattoirs) in endemic areas and should be counselled regarding these risks as part of their pre-travel assessment.
Association of Basic Medical Sciences of FBIH
2006-02-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3203
10.17305/bjbms.2006.3203
Biomolecules and Biomedicine; Vol. 6 No. 1 (2006); 15-18
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3203/882
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3205
2020-07-27T08:52:34Z
bjbms:REV
driver
Osteoporosis - Current Trends in Diagnosis and Management
Kulenović, Indira
Rašić, Senija
Kulenović, Elvedin
osteoporosis
bone mineral density
pharmacotherapy
Osteoporosis (OP) is a generalized skeletal disorder characterized by low bone mineral density (BMD), deterioration of the microarchitecture of bone tissue and susceptibility to fracture. Most frequently it occurs in postmenopausal women and the aged. It is a chronic condition of multifactorial etiology and is a major global healthcare problem in developed and rising in developing countries. Patients with uncomplicated OP are usually asymptomatic which contributes to serious under-diagnosing of this potentially devastating condition. It is estimated that less than half of patients with OP are diagnosed in many developed countries. Therefore preventive measures and timely diagnosis have to be a key aspect of management of this disorder. In this article we briefly underline pato-physiology of the disorder, review current methods of measuring bone mineral density, describe risk factors and evaluate current and potential therapies.
Association of Basic Medical Sciences of FBIH
2006-02-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3205
10.17305/bjbms.2006.3205
Biomolecules and Biomedicine; Vol. 6 No. 1 (2006); 24-28
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3205/884
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3207
2020-07-27T08:53:21Z
bjbms:REV
driver
The Role of the Stroma in Carcinogenesis
Bilalović, Nurija
Vranić, Semir
Serdarević, Fadila
Fočo, Faris
carcinogenesis
tumor stroma
cross-talk
stromal fibroblasts
This systematic review considers the most recent attitudes and news regarding the influence of the stroma on tumor initiation and progression. It is now widely accepted that tumor stroma plays an active role in carcinogenesis. Many different signaling molecules, ligands and signaling pathways recently have been discovered. This review considers the complexity of interactions between malignant cells and its stroma (cross-talk). The recent advances and better understanding of the tumor-stroma interactions will have important impact on the new and combined therapeutic approaches and modalities.
Association of Basic Medical Sciences of FBIH
2006-02-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3207
10.17305/bjbms.2006.3207
Biomolecules and Biomedicine; Vol. 6 No. 1 (2006); 33-38
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3207/886
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3215
2020-07-27T08:53:56Z
bjbms:REV
driver
Eradication of Typhus Exanthematicus in Bosnia and Herzegovina
Puvačić, Zlatko
Bešlagić, Edina
Zvizdić, Šukrija
Puvačić, Sandra
Ravlija, Jelena
Hamzić, Sadeta
Typhus exanthematicus
transmission
eradication
Typhus exanthematicus in Bosnia and Herzegovina held in endemic areas from which especially quickly began spread after 1945. That year, in 1945, one hundred epidemics of typhus fever appeared, with the highest incidence rate in Europe of 215.04 per 1,000. Directions of unique program in the world were to eradicate lice of the body, but also establish monitoring of the recidivism, Brill-Zinsser disease. Since 1971, typhus exanthematicus (classical typhus) hasn't appeared in Bosnia and Herzegovina, so epidemic typhus can considered as an eradicated communicable disease.
Association of Basic Medical Sciences of FBIH
2006-02-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3215
10.17305/bjbms.2006.3215
Biomolecules and Biomedicine; Vol. 6 No. 1 (2006); 71-74
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3215/893
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3223
2020-07-27T09:01:57Z
bjbms:REV
driver
Timing of management of severe injuries of the lower extremity by free flap transfer
Dornseifer, Ulf
Ninković, Milomir
management
injuries
lower extremity
free flap transfer
Covering defects by free-tissue transfers enable surgeons to reconstruct or salvage the lower extremity injured or amputated in high-energy traumas which result in extensive damage to soft tissue, bone, tendons, vessels and nerve. The timing of the reconstruction using flaptechniques is extremely important. It can be divided into three categories: "primary free flap closure" (12 to 24 hours), "delayed primary free flap closure" (2 to 7 days), and "secondary free flap closure" (after 7 days). Our treatment of choice in an isolated complex injury of a lower extremity with a soft tissue defect is "primary free flap closure" providing improved funcional and aesthetic results, and psychologically benefit through lowered morbidity of the patient.
Association of Basic Medical Sciences of FBIH
2005-11-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3223
10.17305/bjbms.2005.3223
Biomolecules and Biomedicine; Vol. 5 No. 4 (2005); 7-13
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3223/898
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3224
2020-07-27T09:02:34Z
bjbms:REV
driver
Management of Open Fractures
Blease, Robert
M. Kanlić, Enes
open fractures
management
The large spectrum of open fractures is an amalgamation of injuries with the single variable in common of communication of the fractured bone with the outside environment, and thus an increased risk for infection. Contributing to the presence of bacteria within the fracture site is devascularized soft tissue, the degree of which can be directly attributed to the amount of energy imparted to the tissues. The currently used classification system aids in defining the degree of severity of these injuries and their subsequent risk for infection. The basic management principal for all of these injury patterns remains essentially the same, however: prevention of infection through debridement, wound management, antibiotic usage, and fracture stabilization. Frequently multiple surgical procedures will be required in order to obtain an infection free, united fracture with adequate soft tissue coverage (1).
Association of Basic Medical Sciences of FBIH
2005-11-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3224
10.17305/bjbms.2005.3224
Biomolecules and Biomedicine; Vol. 5 No. 4 (2005); 14-21
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3224/899
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3227
2020-07-27T09:03:16Z
bjbms:REV
driver
Obesity biological and psychological aspect
Fišeković, Saida
Obesity
BMI
Obesity and depression
NES
BED
leptin
There is no unique pattern to deal with obesity unless is presented as complex of biological and psychological factors. A lot of studies deal with only one side of it. This work shows both sides and discusses about all relevant factors, which are involved in pathogenesis of obesity. This is only way for finding better approaches for treatment and understandings for this issue.
Association of Basic Medical Sciences of FBIH
2005-11-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3227
10.17305/bjbms.2005.3227
Biomolecules and Biomedicine; Vol. 5 No. 4 (2005); 30-34
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3227/902
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3264
2020-07-27T09:48:52Z
bjbms:REV
driver
Brachial Plexus Treatment
Pirela-Cruz, Miguel
Mujadzic, Mirza
Kanlic, Enes
Brachial plexus
treatment
Brachial plexus injuries are devastating injuries that affect primarily young healthy males. For the total plexus injury, current surgical treatments have failed to achieve normal restoration of limb function but some practical goals are obtainable. This review article summarizes existing logic and approach for managing these catastrophic injuries.
Association of Basic Medical Sciences of FBIH
2005-08-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3264
10.17305/bjbms.2005.3264
Biomolecules and Biomedicine; Vol. 5 No. 3 (2005); 7-15
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3264/914
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3265
2020-07-27T09:49:29Z
bjbms:REV
driver
Updates in Flexor Tendon Repair at Zone II
Mujadžić, Mirza
Pirela-Cruz, Miguel
Kanlić, Enes
Flexor tendon
injury
surgical repair
This article reviews the history and current management concepts of flexor tendon lacerations. Classic and contemporary repair techniques are discussed. The most popular rehabilitation protocols are also reviewed.
Association of Basic Medical Sciences of FBIH
2005-08-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3265
10.17305/bjbms.2005.3265
Biomolecules and Biomedicine; Vol. 5 No. 3 (2005); 16-25
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3265/915
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3279
2020-07-28T11:13:19Z
bjbms:REV
driver
Treatment Options for Thoracolumbar Spine Fractures
Karaiković, Eldin E.
Pacheco, Hector O.
thoracolumbar spine fractures
load-sharing classification
short segment fusion
A decision for operative versus nonoperative management of thoracolumbar fractures should NEVER be based solely on one factor. Only after a thorough physical, neurological, and spinal examination, and an assessment of a patient’s prior activity, social and educational background and patient’s expectations, one should review the patient’s radiographs and CT scans to determine risks and benefits of operative versus nonoperative care. Both treatment options are discussed in this paper. As a surgical option our preference is short-segment instrumentation and fusion. Careful and appropriate patient selection and an excellent operative technique insure the minimum complications.
Association of Basic Medical Sciences of FBIH
2005-05-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3279
10.17305/bjbms.2005.3279
Biomolecules and Biomedicine; Vol. 5 No. 2 (2005); 20-26
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3279/929
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3280
2020-07-28T11:13:56Z
bjbms:REV
driver
Extracorporeal Shock Wave Therapy in Orthopaedic Diseases
Trebinjac, Suad
Mujić-Skikić, Emela
Ninković, Marina
Karaiković, Eldin
ESWT
plantar fasciitis
lateral epicondylitis
shoulder disorders
non-union fracture
The application of extracorporeal shock wave therapy (ESWT) as a treatment for different orthopaedic conditions has experienced a rapid increase over the last several years. However the mechanism of action and the therapeutic effect is not clear. The aim of this study was to review the literature about the efficacy of ESWT in the treatment of plantar fasciitis, lateral epicondylitis, shoulder painful disorders and non-union fractures. Only randomized controlled studies published in the last 5 years were retrieved from electronic database and manual search. Results on efficacy of ESWT are controversial. Studies that have claimed therapeutic benefit did not fulfill scientific criteria and controlled randomized trials were not able to confirm significant improvement after treatment with ESWT.
Association of Basic Medical Sciences of FBIH
2005-05-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3280
10.17305/bjbms.2005.3280
Biomolecules and Biomedicine; Vol. 5 No. 2 (2005); 27-32
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3280/930
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3282
2020-07-28T11:15:27Z
bjbms:REV
driver
Modern Approach in Treatment of Diabetes Insipidus
Kapić, Elvedina
Bečić, Fahir
Todić, Maida
desmopressin
diabetes insipidus
In this paper we have reviewed the possition of desmopressin in the treatment of diabetes insipidus. Desmopressin is a synthetic analog of vasopressin, with more pronounced antidiuretic effect. It is treatment of choice in substitution therapy of diabetes insipidus. Its application before sleeping time can reduce nocturnal enuresis, so it has a place in the treatment of enuresis nocturna. Antidiuretic effect of desmopressin is the result of agonistic effect on V2 receptors in the renal tubules. The efficacy and safety of desmopressin in mentioned indications was confirmed in clinical studies.
Association of Basic Medical Sciences of FBIH
2005-05-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3282
10.17305/bjbms.2005.3282
Biomolecules and Biomedicine; Vol. 5 No. 2 (2005); 38-42
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3282/932
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3335
2020-07-28T11:27:13Z
bjbms:REV
driver
Dental treatment of patients with kidney diseases: A review
Sulejmanagić, Halid
Sulejmanagić, Naida
Prohić, Samir
Šečić, Sadeta
Mišeljić, Sanja
kidney disease
dialysis
transplantation
dental treatment
In their practice, every dentist is brought into a situation to treat patients with grossly impaired kidney function. Kidney diseases, whether acute or acquired, imply a number of body dysfunctions such as prolonged bleeding, high blood pressure, infection tendency, etc. which, in turn, pose a threat involving serious complications in cases of dental interventions in these patients. The aim of this article is to provide a review of current dental practice in patients with kidney disease. This implies dental intervention and preparations of patients with chronic renal disease, nephritic syndrome, patients on dialysis, and patients with kidney transplants. Certainly, cooperation between the dentist and nephrologist is imperative for the appropriate dental treatment of patients with grossly impaired renal function.
Association of Basic Medical Sciences of FBIH
2005-02-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3335
10.17305/bjbms.2005.3335
Biomolecules and Biomedicine; Vol. 5 No. 1 (2005); 52-56
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3335/953
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3360
2020-07-28T11:39:48Z
bjbms:REV
driver
Significance of the interferon (IFN) in the therapy
Mahmutović, Sabina
Bešlagić, Edina
Interferon
IFN
Alpha
Beta
and Gamma
Interferons belong to the group of the regulatory glycoproteins, of low molecular mass. They are the products of infected cell-genome, but not virus, as a consequence of the cause answer by different inductors. Human IFN are divided on the sequence of amino-acids into three groups: Alpha, Beta and Gamma interferons. Recently are discovered new types of IFNs: Omega and Tau, but bigger than alpha molecules. Also, has been performed the division into two types: I and II. Besides the antiviral and antiproliferative effects, they have also the effect in the treatment of malignant diseases, and act protectively against the radiation.
Association of Basic Medical Sciences of FBIH
2004-11-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3360
10.17305/bjbms.2004.3360
Biomolecules and Biomedicine; Vol. 4 No. 4 (2004); 42-44
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3360/966
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3365
2020-07-28T11:40:19Z
bjbms:REV
driver
Growth hormone (GH) usage and abuse
Hadžović, Almira
Nakaš-Ićindić, Emina
Kucukalić-Selimović, Elma
Salaka, Abdul-Umid
growth hormone
therapeutic use
abuse
Growth hormone is essential for body growth but it also modulates metabolic pathways as well as neural, reproductive, immune, cardiovascular, and pulmonary functions. Numerous beneficial effects of growth hormone have led to its expanded therapeutic use in both children and adults. There are several officially approved applications of human growth hormone and many more proposed applications that resulted from huge number of clinical studies on GH therapy.
Growth hormone abuse includes improper or excessive use. Over the last decade GH has become one of the most commonly abused drugs in sport due to the fact that its administration is currently undetectable. Enormous doses that are injected and frequent simultaneous abuse of other substances such as other anabolic steroids (testosterone) lead to frequent side effects that may be fatal.
In spite of numerous beneficial effects of growth hormone the true physiological impact of GH replacement therapy on various metabolic parameters may be confounded by the dose and route of administration of GH so accurate physicians’ monitoring during GH therapy is needed.
Association of Basic Medical Sciences of FBIH
2004-11-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3365
10.17305/bjbms.2004.3365
Biomolecules and Biomedicine; Vol. 4 No. 4 (2004); 66-70
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3365/971
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3381
2020-07-28T12:30:50Z
bjbms:REV
driver
Endothelin in health and disease
Nakaš-Ićindić, Emina
Začiragić, Asija
Hadžović, Almira
Avdagić, Nešina
endothelin
physiological and pathophysio-logical effects
Endothelin is a recently discovered peptide composed of 21 amino acids. There are three endothelin isomers: endothelin -1 (ET-1), endothelin -2 (ET-2) and endothelin - 3 (ET-3). In humans and animals levels of ET-1, ET-2, ET-3 and big endothelin in blood range from 0,3 to 3 pg/ml. ET-1, ET-2 and ET-3 act by binding to receptors. Two main types of the receptors for endothelins exist and they are referred to as A and B type receptors. Different factors can stimulate or inhibit production of endothelin by endothelial cells. Mechanical stimulation of endothehum, thrombin, calcium ions, epinephrine, angiotensin II, vasopressin, dopamine, cytokines, growth factors stimulate the production of endothelin whereas nitric oxide, cyclic guanosine monophosphate, atrial natriuretic peptide, prostacyclin, bradykinin inhibit its production. Endothelins have different physiological roles in human body but at the same time their actions are involved in the pathogenesis of many diseases.
The aim of this review was to present some of, so far, the best studied physiological roles of endothelin and to summarize evidence supporting the potential role of ET in the pathogenesis of certain diseases.
Association of Basic Medical Sciences of FBIH
2004-08-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3381
10.17305/bjbms.2004.3381
Biomolecules and Biomedicine; Vol. 4 No. 3 (2004); 31-34
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3381/980
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3383
2020-07-28T12:31:56Z
bjbms:REV
driver
Amorphous Pharmaceutical Solids.
Vranić, Edina
amorphous solids
preparation
characterization
stabilization
Amorphous forms are, by definition, non-crystalline materials which possess no long-range order. Their structure can be thought of as being similar to that of a frozen liquid with the thermal fluctuations present in a liquid frozen out, leaving only “static” structural disorder. The amorphous solids have always been an essential part of pharmaceutical research, but the current interest has been raised by two developments: a growing attention to pharmaceutical solids in general, especially polymorphs and solvates and a revived interest in the science of glasses and the glass transition.
Amorphous substances may be formed both intentionally and unintentionally during normal pharmaceutical manufactoring operations. The properties of amorphous materials can be exploited to improve the performance of pharmaceutical dosage forms, but these properties can also give rise to unwanted effects that need to be understood and managed in order for the systems to perform as required.
Association of Basic Medical Sciences of FBIH
2004-08-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3383
10.17305/bjbms.2004.3383
Biomolecules and Biomedicine; Vol. 4 No. 3 (2004); 35-39
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3383/981
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3404
2020-07-29T08:42:06Z
bjbms:REV
driver
Editorial
Board, Editorial
editorial
We have completed publication of seven authors’ oral presentations given on 15. February 2003. at Symposium “Scientific, ethical and religious dilemmas on the status of human embryo and its cloning”.
This journal invokes increased interest amongst workers engaged in almost all the fields complementary to basic research and implicit to biological as well as biomedical science.
In the situation when financial and human potential of our country border on existence and the young and the talented continuously migrate to the developed and wealthy countries, integration of all the existing resources and research teams and presentation of their research results seems to be possible only in a journal capable of combining them all.
However, we are certain that our cooperation with the developed scientific communities will result in repatriation of scientists from our country who work there successfully, and in their integration into environment which they left not only to ensure existence for themselves but also to satisfy scientific curiosity and become competent modern experts.
With all the sincerity, we offer to them collaboration in the presentation of their research results in our journal, as well as joint realization of scientific research.
May, 2004
Editorial Board
Association of Basic Medical Sciences of FBIH
2008-05-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3404
10.17305/bjbms.2004.3404
Biomolecules and Biomedicine; Vol. 4 No. 2 (2004); 3-4
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3404/987
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3405
2020-06-06T21:54:26Z
bjbms:REV
driver
High performance liquid chromatography in pharmaceutical analyses
Nikolin, Branko
Imamović, Belma
Medanhodžić-Vuk, Saira
Sober, Miroslav
HPLC
stationary phase
separation of enentiomers
decomposition products
In testing the pre-sale procedure the marketing of drugs and their control in the last ten years, high performance liquid chromatographyreplaced numerous spectroscopic methods and gas chromatography in the quantitative and qualitative analysis. In the first period of HPLC application it was thought that it would become a complementary method of gas chromatography, however, today it has nearly completely replaced gas chromatography in pharmaceutical analysis. The application of the liquid mobile phase with the possibility of transformation of mobilized polarity during chromatography and all other modifications of mobile phase depending upon the characteristics of substance which are being tested, is a great advantage in the process of separation in comparison to other methods. The greater choice of stationary phase is the next factor which enables realization of good separation. The separation line is connected to specific and sensitive detector systems, spectrafluorimeter, diode detector, electrochemical detector as other hyphernated systems HPLC-MS and HPLC-NMR, are the basic elements on which is based such wide and effective application of the HPLC method. The purpose high performance liquid chromatography(HPLC) analysis of any drugs is to confirm the identity of a drug and provide quantitative results and also to monitor the progress of the therapy of a disease.1) Measuring presented on the Fig. 1. is chromatogram obtained for the plasma of depressed patients 12 h before oral administration of dexamethasone. It may also be used to further our understanding of the normal and disease process in the human body trough biomedical and therapeutically research during investigation before of the drugs registration. The analyses of drugs and metabolites in biological fluids, particularly plasma, serum or urine is one of the most demanding but one of the most common uses of high performance of liquid chromatography. Blood, plasma or serum contains numerous endogenous compounds often present in concentrations much greater than those of analyte. Analiyte concentrations are often low, and in the case of drugs, the endogenous compounds are sometimes structurally very similar to the drug to be measured. The binding of drugs to the plasma protein also may occur which decreases the amount of free compound that is measured. To undertake the analyses of drugs and metabolites in body fluids the analyst is facet with several problems. The first problem is due to the complex nature of the body fluid, the drugs must be isolated by an extraction technique, which ideally should provide a relatively clean extract, and the separation system must be capable of resolving the drugs of interest from co extractives. All mentioned when we are using high performance liquid chromatography require good selections of detectors, good stationary phase, eluents and adequate program during separation. UV/VIS detector is the most versatile detector used in high performance liquid chromatography it is not always ideal since it is lack of specificity means high resolution of the analyte that may be required. UV detection is preferred since it offers excellent linearity and rapid quantitative analyses can be performed against a single standard of the drug being determined. Diode array and rapid scanning detector are useful for peak identification and monitoring peak purity but they are somewhat less sensitive then single wavelength detectors. In liquid chromatography some components may have a poor UV chromophores if UV detection is being used or be completely retained on the liquid chromatography column. Fluorescence and electrochemical detector are not only considerably more sensitive towed appropriate analytes but also more selective than UV detectors for many compounds. If at all possible fluorescence detectors are sensitive, stable, selective and easy to operate. It is selectivity shows itself in the lack of frontal components observed in plasma extract whereas electrochemical detection is nearly always associated with a major frontal peak than tails considerably. To date, the most sensitive method has been the reductive electrochemical detection and giving the excellent results in the investigation on some classes of drugs. Several high performance liquid chromatography oxidative electrochemical methods have been developed for the analyses of drugs and metabolites in body fluids. Mass spectrometer as specific detector with all variation of ionisation and interface (thermo spray, moving belt etc. ) or liquid chromatography-tandem mass spectrometry2,3,4,5). NMR as selective and specific detector in high performance liquid chromatography today is also in used. The development of a non-aqueous eluent for ion-exchange separation on silica has provided an excellent system which, when used in conjugation with an electrochemical detector, permits the analyses of an extensive range of especially basic drugs and metabolites. New packing materials such as polymeric, base deactivated silica's, pyrolysed carbon and the internal surface packing should offer the improved stability and higher efficiencies for certain classes of the compounds such as basic drugs. Microbore columns should become more accepted since they offer not only improved sensitivity but also a lower solvent consumption and consequently the reduced needs to dispose of noxious solvents. Many analyses of basic drugs are still performed by the same method of the ion-exchange chromatography on unmodified silica columns with an eluent buffered to about pH 9. Neutral or weakly acidic drugs for instance barbiturates can be chromatographed on a reversed phase system whilst acidic drugs for example paracetamol, cannabis are separated either by ion suppression or ion-pair chromatography on a reversed-phase packing material. In micelar liquid chromatography micelar mobile phases in reversed-phase instead of conventional hydro organic mobile phase is used. In micelar liquid chromatography complex electrostatic hydrophobic and steric interactions exist between the solute and both stationary and mobile phases. These enable the effective separation of samples of different nature. The main advantages of the use of a micelar solution in reversed-phase liquid chromatography are the solvent and the lower cost and toxicity, the biodegradability of the solvent and the easy dissolution of analytical samples, that enables the determination of drugs in physiological fluids without the need for previous separation of the proteins present in the samples. Using tetrabutylammonium phosphate as a competing base in the investigation of sulphonamides and heptanes sulfonate as ion pairing reagent. Ion pairing reagent is term used to describe enhanced retention as the result of the addition to the mobile phase of a large ion opposite charge to the molecular ions to be separated. For molecular cations alkyl sulphates or sulfonates are generally utilised.
Association of Basic Medical Sciences of FBIH
2004-05-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3405
10.17305/bjbms.2004.3405
Biomolecules and Biomedicine; Vol. 4 No. 2 (2004); 5-9
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3405/988
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3405/1341
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3410
2020-07-29T08:42:29Z
bjbms:REV
driver
Sonophoresis-mechanisms and application
Vranić, Edina
sonophoresis
mechanism
application
ultrasound
cavitation
enhancement
transdermal
drug delivery
There are numerous methods of administering drugs to the body, both passive and active. Active methods include the use of penetration enhancers and assisted drug delivery. One of them is sonophoresis (phonophoresis). This term is used to describe the effects of ultrasound on the movement of drugs through intact living skin and into the soft tissues. Although the exact mechanism of sonophoresis is not known, drug absorption may involve a disruption of the stratum corneum lipids allowing the drug to pass through the skin. In the future, drug release systems aided by ultrasound may be able to provide slow release of vaccines. Researchers are currently exploring the applications in various areas like cutaneous vaccination, transdermal heparin delivery, transdermal glucose monitoring, delivery of acetyl cholinesterase inhibitors for the treatment of Alzheimer's disease, treatment of bone diseases and Peyronie's disease and dermal exposure assessment. The possibilities seem endless. Drug administration through skin patches, with the advent and development of ultrasound-mediated transdermal transport, may soon become the name of the game. Besides, taking into account the varied possible applications of sonophoretic transdermal drug transport in the fields of biotechnology and genetic engineering, we can envision a whole gamut of newer technologies and products in the foreseeable future.
Association of Basic Medical Sciences of FBIH
2008-05-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3410
10.17305/bjbms.2004.3410
Biomolecules and Biomedicine; Vol. 4 No. 2 (2004); 25-32
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3410/993
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3410/1342
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3412
2020-07-29T08:43:02Z
bjbms:REV
driver
Different digital imaging techniques in dental practice
Lačević, Amela
Vranić, Edina
digital imaging
radiography
image processing
Different imaging techniques are used to pick up the signal of interest in digital sensors, including charge-coupled devices (CCD), complementary metal-oxide semiconductors (CMOS), photostimulable phosphors plates (PSP) and tuned-aperture computed tomography (TACT) Digital radiography sensors are divided into: storage phosphor plates (SPP) called photostimulable phosphor plates (PSP), silicon devices such as charge-coupled devices (CCD) or complementary metal oxide semiconductors (CMOS). Relatively new type of imaging that may hold advantage over current radiographic modalities is tuned-aperture computed tomography (TACT).
Association of Basic Medical Sciences of FBIH
2004-05-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3412
10.17305/bjbms.2004.3412
Biomolecules and Biomedicine; Vol. 4 No. 2 (2004); 37-40
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3412/995
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3412/1343
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3421
2020-07-29T08:44:54Z
bjbms:REV
driver
Basic principles of drug--excipients interactions
Vranić, Edina
excipient
drug
interaction
Excipients are generally considered inert additives included in drug formulation to help in the manufacturing, administration or absorption. Other reasons for inclusion concern product differentiation, appearance enhancement or retention of quality. Excipients can initiate, propagate or participate in chemical or physical interactions with an active substance, possibly leading to compromised quality or performance of the medication. Understanding the chemical and physical nature of excipients, the impurities or residues associated with them and how they may interact with other materials, or with each other, forewarns the pharmaceutical technologist of possibilities for undesirable developments.
Association of Basic Medical Sciences of FBIH
2004-05-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3421
10.17305/bjbms.2004.3421
Biomolecules and Biomedicine; Vol. 4 No. 2 (2004); 56-58
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3421/998
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3421/1344
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3451
2021-06-22T15:45:17Z
bjbms:REV
driver
Therapeutic flexible bronchoscopy in child with cystic fibrosis
Selimović, Amina
flexible bronchoscopy
cystic fibrosis
child
therapy
The report deals with the case of a 10-year-old girl with chronic cystic fibrosis. She has been repeatedly treated at the hospital. She has been hospitalized due to respiratory deterioration. Cystic fibrosis is a rare disease, inherited autosomaly recessively, but is very complex in terms of diagnostic and treatment (2). The diagnosis is confirmed based on a clinical picture of the child, measure of Chloride in the sweat, chest X-ray, CT thorax, laboratory findings--genetic confirmation CFTR ( cystic fibrosis transmembrane conductance regulator) genes (3), which result in the production of hyper-viscous mucus and chloride malabsorption in the sweat glands ducts (5,6). Bronchial thickening and plugging and ring shadows suggesting bronchiectasis, segmental or lobar atelectasis are often. Computer tomography of the chest can be used to detect and localize thickening of bronchial airways walls, mucus plugging, hyperinflation and early bronchieactasiae. Pulmonary therapy: the object is to clear secretions from airways and to control infection (7). The diagnosis is originally set when she was 4 years old. She is now admitted due to a deterioration of the main disease. Day before admission in the hospital had a higher bodily temperature, cough and difficult breathing. She already treated conservatively (Ceftazidim, Ceftriakson, Kloksacillin) Since the girl is a chronic patient with bronchiectasie chronic walls of bronchi changes full of the mucus, who is not responding to conservative treatment (antibiotics), therapeutic and diagnostic flexible bronchoscopy had to be performed, resulting in a gram-negative bacteria pseudomonas aeruginosa--a typical bacteria for chronically sick C. F.
PATIENT:
A pseudomonas therapy was prescribed according to the sensitive antibiogram, during which bronchoscopy was given locally on changes mucous pulmozyme and garamycin. Flexible bronchoscopy was performed as therapeutic. Local bronchoscopy findings:by aspiration of tracheo-bronchal truncus it was found hyperemia and a lot of mucous sticky secretion inside of tracheobronchal tree, especially middle lobe right side, lingual and basals part of the lungs. It was performed broncho-alveolar lavage and given steroids on the place of changed inflamed mucous membrane of the bronchi. It was also given pulmozyme to destroid mucous and make better spontaneously expectorations. Control chest x ray was performed and it was better.
Association of Basic Medical Sciences of FBIH
2008-05-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3451
10.17305/bjbms.2005.3451
Biomolecules and Biomedicine; Vol. 5 No. 2 (2005); 75-77
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3451/1009
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3453
2020-07-29T09:01:08Z
bjbms:REV
driver
The facts and doubts about beginning of the human life and personality
Kurjak, Asim
Tripalo, Ana
beginning of human life
personality
embrion
“What a piece of work is a man!” William Shakespeare, Hamlet
“To those of average curiosity about the wonders of nature, it is likely that two great mysteries have stirred the imagination; and each concerns a birth. Who has not gazed into the heavens on the starlit night and wondered about the birth of the universe? And who has not been stimulated by the sight of the newly born baby to the marvel at the unseen events within the mother’s uterus that have led to the birth of such a perfect creation?”(1) These words written by the Professor Sir Graham (Mont) Liggins open Pandora’s box of questions, dilemmas, doubts and controversies about human life and its beginning offering everybody lifelong challenge to solve mystery of life.
Entering this filed scientists have been remiss in failing to translate science into the terms that allow mankind to share their excitement of discovering life before birth. Regardless to remarkable scientific development, curiosity, and speculations dating back to Hippocrates, life before birth still remains a big secret. Different kinds of intellectuals involved themselves trying to contribute to the solution of human life puzzle. They are led by the idea that each newborn child will only reach its full potential if its development in uterus is free from any adverse influence, providing the best possible environment for the embryo/foetus. Considering embryo/foetus, it should be always kept in mind amazing aspect of these parts of human life in which the mother and the embryo/foetus, although locked in the most intimate relationships, are at ALL TIMES two separate people. Accepting embryo/foetus as the person opened new set of questions about its personality and human rights. Today, synthesis between scientific data and hypotheses, philosophical thought, and issues in the humanities, has become pressing necessity in order to deal with ethical, juridical and social problems arising from man’s interference in many aspects and stages of life. (2)
Association of Basic Medical Sciences of FBIH
2004-02-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3453
10.17305/bjbms.2004.3453
Biomolecules and Biomedicine; Vol. 4 No. 1 (2004); 5-14
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3453/1336
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3453/1337
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3454
2020-07-29T09:02:21Z
bjbms:REV
driver
Arguments for Human Therapeutic Cloning
Pavelić, Krešimir
cloning
therapeutic cloning
ethics
For over 30 years, many Western governments have regulated scientific research involving human subjects. According to Knoppers implementation of regulation followed a long and checkered history of research abuse. The regulations evolved largely in response to ethical violations. The Nuremberg Codex exemplifies the progression. It was adopted in 1947. At the conclusion of the Nazi Doctors Trial.
Spectacular technical and conceptual advances in modern biology and molecular medicine have solved many problems in a short time. Genetic diagnostics extended well beyond simple inheritance testing, and is now moving into all areas of pathology. Gene therapy, although in a phase of consolidation after an exuberant youth, holds real promise. Understanding the molecular basis of tissue differentiation, perhaps with the use of nuclear transfer techniques, may allow the creation of histocompatible tissue for transplantation purposes.
Scientific work will have propounds long-term consequences for medicine, leading to the elucidation of the underlying molecular mechanisms of disease and thereby facilitating the design of rational diagnostics and therapeutics targeted at those mechanisms.
All molecular medicine must operate within a social and ethical context.
The prominence of ethical controversy (i.e. presymptomatic genetical testing, or human therapeutically cloning) will very likely diminish with time, as the products of molecular medicine range further away from establishing pure diagnostic and into therapy.
One of the major issues of today’s modern medicine is therapeutically cloning. The main practical purpose of cloning is to generate genetically modified animals to serve as bioreactors. The cloning of mammals is a fascinating biological problem, although it is difficult to perform and attempts are rarely successful. The reproductive cloning of humans is likely to cause more individual concern than real social effects, as it is unlikely to become a widespread method of reproduction even if possible and safe.
Association of Basic Medical Sciences of FBIH
2008-02-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3454
10.17305/bjbms.2004.3454
Biomolecules and Biomedicine; Vol. 4 No. 1 (2004); 15-18
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3454/1011
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3454/1334
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3468
2020-07-29T09:03:22Z
bjbms:REV
driver
Endodontic-periodontal locally delivered antibiotics
Lačević, Amela
Vranić, Edina
Zulić, Irfan
local delivery
antibiotics
delivery devices
periodontal
root canal
Endodontic pathology is a bacterial disease. It is well established that periapical disease is the result of bacteria, their product, and the host response to them. Periradicular disease will occur after microorganisms and their metabolic products affect the periradicular tissue. Aim of using antibiotics as part of a treatment regimen is to achieve, within the periodontal environment, a concentration of the drug that is sufficient either to kill (bactericidal) or arrest the growth (bacteriostatic) of pathogenic microorganisms. There are two possible approaches to improve the drug action: sustained and controlled drug release to reduce or eliminate side effects by improving the therapeutic index and site-specific drug delivery to minimize systemic effects. These two strategies have been explored by the association of drugs with different vehicles, either naturals or synthetics. A wide variety of specialized local delivery systems (i.e.intrapocket devices) have been designed to maintain the antibiotic in the GCF (gingival crevicular fluid) at a concentration higher than the MIC (minimum inhibitory concentration). Fibres, films, strips and microparticles made of biodegradable or non-biodegradable polymers have been reported as effective methods to administer antibacterial agents for periodontal therapy. Together with these solid devices, semisolid adhesive or non-adhesive formulations have also been proposed.
Association of Basic Medical Sciences of FBIH
2004-02-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3468
10.17305/bjbms.2004.3468
Biomolecules and Biomedicine; Vol. 4 No. 1 (2004); 73-78
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3468/1024
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3468/1338
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3477
2020-12-27T09:36:58Z
bjbms:REV
driver
MicroRNAs: Recent insights towards their role in male infertility and reproductive cancers
Khawar, Muhammad Babar
Mehmood, Rabia
Roohi, Nabila
Infertility
microRNAs
miRNAs
noncoding RNAs
reproductive cancers
spermatogenesis
Spermatogenesis is a tightly controlled, multi-step process in which mature spermatozoa are produced. Disruption of regulatory mechanisms in spermatogenesis can lead to male infertility, various diseases of male reproductive system, or even cancer. The spermatogenic impairment in infertile men can be associated with different etiologies, and the exact molecular mechanisms are yet to be determined. MicroRNAs (miRNAs) are a type of non-protein coding RNAs, about 22 nucleotides long, with an essential role in post-transcriptional regulation. miRNAs have been recognized as important regulators of various biological processes, including spermatogenesis. The aim of this review is to summarize the recent literature on the role of miRNAs in spermatogenesis, male infertility and reproductive cancers, and to evaluate their potential in diagnosis, prognosis and therapy of disease. Experimental evidence shows that aberrant expression of miRNAs affects spermatogenesis at multiple stages and in different cell types, most often resulting in infertility. In more severe cases, dysregulation of miRNAs leads to cancer. miRNAs have enormous potential to be used as diagnostic and prognostic markers as well as therapeutic targets in male infertility and reproductive system diseases. However, to exploit this potential fully, we need a better understanding of miRNA-mediated regulation of spermatogenesis, including the characterization of yet unidentified miRNAs and related regulatory mechanisms.
Association of Basic Medical Sciences of FBIH
2019-02-12
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3477
10.17305/bjbms.2018.3477
Biomolecules and Biomedicine; Vol. 19 No. 1 (2019); 31-42
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3477/1136
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3477/1763
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3484
2020-07-29T09:15:04Z
bjbms:REV
driver
Proteasome inhibitors: new class of antitumor agents
Srkalović, Gordan
proteasome inhibitors
antitumor agents
The ubiquitin-proteasome pathway is the principal pathway for intracellular protein degradation1,2 (Fig 1). This pathway selectively degrades an extensive number of short-lived regulatory proteins involved in the control of normal cellular processes. In order to be degraded, proteins targeted by the ubiquitin-proteasome pathway are covalently tagged by polyubiquitination, via a three-step enzymatic process, which ultimately leads to their recognition and degradation, by the 26S proteasome in a highly specific and regulated manner. This process is accomplished by the sequential action of three enzymes: an ATP-dependent ubiquitin-activating enzyme (E1), an ubiquitin-conjugating enzyme (E2) and an ubiquitin-pro-tein ligase (E3).3 This cascade covalently links the C terminus of ubiquitin to a free amino group on the target protein, usually the ε-amino of a lysine residue.
Association of Basic Medical Sciences of FBIH
2003-11-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3484
10.17305/bjbms.2003.3484
Biomolecules and Biomedicine; Vol. 3 No. 4 (2003); 5-10
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3484/1027
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3488
2020-07-29T09:15:57Z
bjbms:REV
driver
Clinical application of calcium hydroxide in dental pathology and endodontics
Lačević, Amela
Vranić, Edina
Zulić, Irfan
calcium hydroxide
antibacterial
mineralizing
pH
vehicles
clinical application
Calcium hydroxide has a hard tissue inducing effect. It is a powder, that can be mixed with a physiological saline to a paste. The paste is highly alkaline with a pH 12.5 and its application to the pulp results in necrosis of the part of coronal pulp tissue shows no or only a milled inflammatory reaction. Analyzing the pH and the concentration of calcium ions in the periapical area, it is obvious that at least 2 weeks are necessary for calcium hydroxide bactericide activity. Calcium hydroxide retains its anti-bacterial properties for about two months when placed under a restoration, after which it degrades to calcium oxide and other less effective calcium salts. All calcium hydroxide preparations have a limited shelf life as they eventually turn into calciumoxide. Calcium hydroxide can be used as linings, for indirect and direct pulp cupping, root dressing, root canal sealant, apical closure. The vehicles play a supportive role, giving pastes chemical characteristics such as dissociation and diffusion as well as favoring the correct filling of the root canal which are decisive factors for antimicrobial potential and tissue healing. The mechanism of action of calcium hydroxide on tissues, inducing the deposition of mineralized tissue, is an extremely important aspect for the indication of calcium hydroxide, because it demonstrates biological compatibility of calcium hydroxide.
Association of Basic Medical Sciences of FBIH
2003-11-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3488
10.17305/bjbms.2003.3488
Biomolecules and Biomedicine; Vol. 3 No. 4 (2003); 26-29
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3488/1031
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3527
2020-07-29T09:26:05Z
bjbms:REV
driver
Cardiac troponin I: the gold standard in acute myocardial infarction diagnosis
Hasić, Sabaheta
Kiseljaković, Emina
Jadrić, Radivoj
Radovanović, Jovan
Winterhalter-Jadrić, Mira
cardiac troponin I
acute myocardial infarction
diagnosis
gold standard
Cardiovascular diseases are leading cause of morbidity in the world. Measurement of the level of biochemical markers in the serum is one of World Health Organisation (WHO) criteria in diagnosing acute myocardial infarction (AMI). Non-specific clinical state of patients and insufficiently sensitive electrocardiographic (ECG) diagnostics, at patient's hospital admission time, point out the importance of biochemical markers in acute myocardial infarction diagnosis. Technology development and new diagnostic methods lead to the invention of highly sensitive and specific marker as myocardialdamage evidence. Cardiac Troponin I (cTnI) is specific marker for myocardial damage1. Its elevation in the serum within myocardial ischemia symptomatology is important in diagnosis of myocardial infarction.
Association of Basic Medical Sciences of FBIH
2003-08-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3527
10.17305/bjbms.2003.3527
Biomolecules and Biomedicine; Vol. 3 No. 3 (2003); 41-44
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3527/1054
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3528
2020-07-29T09:26:46Z
bjbms:REV
driver
Introduction of the new analytical approaches to the doping control on the XIV Winter Olympic Games
Nikolin, Branko
Lekić, Meliha
Sober, Miroslav
doping control
anabolic steroids
exogenous testosterone
gas chromatography-mass spectrometry
XIV Winter Olympic Games
In this paper we present introduction and development of some new analytical methods for identification of anabolic steroids, their metabolites and certain hormones, especially determination of exogenous testosterone by means of gas chromatography-mass spectrometry. Identification of central nervous stimulants and corticosteroides has been performed by high performance liquid chromatography. In desire to achieve better results, to increase strength and endurance, to sharpen reflexes and to reduce stress and anxiety athletes as well as other people use different pharmacological substances, hormones or even illicit drugs. Use of these substances without medical supervision can lead to adverse effects to one's health or even cause a death. At the same time, use of such substances means a kind of cheat that could not be accepted. This is why International Olympic Committee started at 1968 with official dopingcontrol that is permanently carried out and continuously increasing number of banned substances. Doping controldemands for discover and development of new sensitive and specific methods for detection of banned substances and their metabolites in urine and blood.
Association of Basic Medical Sciences of FBIH
2003-08-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3528
10.17305/bjbms.2003.3528
Biomolecules and Biomedicine; Vol. 3 No. 3 (2003); 45-49
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3528/1055
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3530
2020-07-29T09:27:31Z
bjbms:REV
driver
Iontophoresis: fundamentals, developments and application
Vranić, Edina
iontophoresis
transport
patches
application
The skin is an excellent barrier to the transport of charged compounds and large molecules. Many substances of present and potential therapeutic utility carry charge at physiological pH, have high molecular weights and/or are hydrophilic and, consequently, do not transport well across the skin. Pathways for the transport of small ions do appear to exist through the skin and flow along these pathways can be substantially enhanced by iontophoresis.
Association of Basic Medical Sciences of FBIH
2003-08-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3530
10.17305/bjbms.2003.3530
Biomolecules and Biomedicine; Vol. 3 No. 3 (2003); 54-58
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3530/1057
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3532
2020-12-27T09:32:29Z
bjbms:REV
driver
Cannabinoids in cancer treatment: Therapeutic potential and legislation
Dariš, Barbara
Tancer Verboten, Mojca
Knez, Željko
Ferk, Polonca
Cannabinoids
antitumor effects
signaling pathways
legislation
The plant Cannabis sativa L. has been used as an herbal remedy for centuries and is the most important source of phytocannabinoids. The endocannabinoid system (ECS) consists of receptors, endogenous ligands (endocannabinoids) and metabolizing enzymes, and plays an important role in different physiological and pathological processes. Phytocannabinoids and synthetic cannabinoids can interact with the components of ECS or other cellular pathways and thus affect the development/progression of diseases, including cancer. In cancer patients, cannabinoids have primarily been used as a part of palliative care to alleviate pain, relieve nausea and stimulate appetite. In addition, numerous cell culture and animal studies showed antitumor effects of cannabinoids in various cancer types. Here we reviewed the literature on anticancer effects of plant-derived and synthetic cannabinoids, to better understand their mechanisms of action and role in cancer treatment. We also reviewed the current legislative updates on the use of cannabinoids for medical and therapeutic purposes, primarily in the EU countries. In vitro and in vivo cancer models show that cannabinoids can effectively modulate tumor growth, however, the antitumor effects appear to be largely dependent on cancer type and drug dose/concentration. Understanding how cannabinoids are able to regulate essential cellular processes involved in tumorigenesis, such as progression through the cell cycle, cell proliferation and cell death, as well as the interactions between cannabinoids and the immune system, are crucial for improving existing and developing new therapeutic approaches for cancer patients. The national legislation of the EU Member States defines the legal boundaries of permissible use of cannabinoids for medical and therapeutic purposes, however, these legislative guidelines may not be aligned with the current scientific knowledge.
Association of Basic Medical Sciences of FBIH
2019-02-12
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3532
10.17305/bjbms.2018.3532
Biomolecules and Biomedicine; Vol. 19 No. 1 (2019); 14-23
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3532/1121
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3532/1761
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3539
2020-12-28T13:41:38Z
bjbms:REV
driver
Recent advances in research on aspartate β-hydroxylase (ASPH) in pancreatic cancer: A brief update
Hou, Guofang
Xu, Boran
Bi, Yanghui
Wu, Chuanlin
Ru, Beibei
Sun, Bei
Bai, Xuewei
Aspartate β-hydroxylase
pancreatic cancer
Notch signaling pathway
Mitochondrial DNA
NK cell
Pancreatic cancer (PC) is a highly aggressive tumor, often difficult to diagnose and treat. Aspartate β-hydroxylase (ASPH) is a type II transmembrane protein and the member of α-ketoglutarate-dependent dioxygenase family, found to be overexpressed in different cancer types, including PC. ASPH appears to be involved in the regulation of proliferation, invasion and metastasis of PC cells through multiple signaling pathways, suggesting its role as a tumor biomarker and therapeutic target. In this review, we briefly summarize the possible mechanisms of action of ASPH in PC and recent progress in the therapeutic approaches targeting ASPH.
Association of Basic Medical Sciences of FBIH
2018-11-05
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3539
10.17305/bjbms.2018.3539
Biomolecules and Biomedicine; Vol. 18 No. 4 (2018); 297-304
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3539/1122
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3539/1787
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3546
2020-07-30T10:34:11Z
bjbms:REV
driver
Cloning-dilemmas-third-millennium-where to go in the future?
Gavrankapetanović, Faris
cloning
dilemmas
future
“We think that science has already explained all when explained movement of the Moon around the Earth. But the real world is not universe like a simple pendulum clock.”
Jim York, a physicist from the University of Maryland who coined the name “chaos”
We are assured that the field of “Human Cloning” comprise the most crucial scientific questions of present time. It seems that all exaltation of its progress and fascinating results have vanished while being replaced with the cogitative concern that Immanuel Kant expressed in three fundamental questions:
What can I know?
What should I do?
What may I hope?
While considering all these questions famous philosopher thought about any human being.
Today, these queries consideration is based on the experience of illuminator “ingress” in all that exist, as well as in the human being itself. Experience of the “illumination” triumph seduces science beyond its achievements and freedoms. We would say that science wants even beyond its real wants. Nowadays, global scientific impact appears as general opinions correlated to the universe of technological utilisation, professionalism in knowledge and biological science influence on the behavioural inducements.
The basic thinking principles established by modern science are inseparable from the statements of philosopher Descartes: “World of mind and world of body are separated as individual substances that exist separately without any needful co-existence”. In that way, a new authoritative scientific relation towards the world has been created, out of which, the field of values “Heavens are devoid of the glory of God” (A.N. Whitehead, “Science and the modern world”) has been completely excluded or eliminated.
It is obvious that the crucial postulations of nature are created throughout gathering of the sufficient data and simplification of the numerous correlative causes and consequences in other to elucidate “the anarchy of systems” and accomplish the exact predictions of their attitudes. Amazing technological progress in 20th century made many people believe that some day science would find out all ignorance of nature and improve the control over it. According to that assumption, the attitude of very complex dynamic systems would finally conform to the scientific formulations and calculations.
A fascinating thoughtful help of chaosologists, particularly in their theory of fractals that revealed an apprehension of the reality as made from worlds within self-similar worlds i.e. worlds within dimensions, is necessary for the proper quantification of defect associated with the progress in knowledge of life. That knowledge has been previously neglected to the simple scientific facts and responsibilities (especially in medicine) that naturally appear from inside when life is recognised as a holistic system.
Association of Basic Medical Sciences of FBIH
2003-05-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3546
10.17305/bjbms.2003.3546
Biomolecules and Biomedicine; Vol. 3 No. 2 (2003); 5-11
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3546/1062
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3554
2020-07-30T10:36:54Z
bjbms:REV
driver
Classification and evaluation of medical devices
Vranić, Edina
medical devices
classification
manufacture
evaluation
Medical devices and medical disposables contribute significantly to the quality and effectiveness of the health care system. It is necessary to commit scientifically sound regulatory environment that will provide consumers with the best medical care. This includes continued services to small manufacturers, readily available guidance on FDA requirements, predictable and reasonable response times on applications for marketing, and equitable enforcement. But in the public interest, this commitment to the industry must be coupled with a reciprocal commitment: that medical device firms will meet high standards in the design, manufacture, and evaluation of their products. The protections afforded our consumer, and the benefits provided the medical device industry, cannot be underestimated.
Association of Basic Medical Sciences of FBIH
2003-05-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3554
10.17305/bjbms.2003.3554
Biomolecules and Biomedicine; Vol. 3 No. 2 (2003); 42-45
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3554/1068
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3555
2020-07-30T10:37:49Z
bjbms:REV
driver
SARS: current overview, aetiology and epidemiology
Čavaljuga, Semra
Faulde, Michael
J. Scharninghausen, Jerrold
SARS
aetiology
epidemiology
At this moment, public health authorities, physicians and scientists around the world are struggling to cope with a severe and rapidly spreading new disease in humans called severe acute respiratory syndrome, or SARS. According to World Health Organisation (WHO) this appears to be the first severe and easily transmissible new disease to emerge in the 21st century. Though much about the disease remains poorly understood, including the details of the causative virus, we do know that it has features that allow it to spread rapidly along international air travel routes. As of 10 May 2003, a cumulative 7296 probable SARS cases with 526 deaths have been reported from 30 countries on three continents (WHO, ProMED). In the past week, more than 1000 new probable cases and 96 deaths were reported globally. This represents an increase of 119 new cases and 8 new deaths compared with 9 May 2003 (China (85), Taiwan (23), and Hong Kong (7) represented the overwhelming majority, with one additional case each reported from France, Malaysia, Singapore, and the United States). Only in China, as of 10 May 2003 (WHO) total of 4884 with 235 deaths have been reported. Some outbreaks have reassuring features.
Association of Basic Medical Sciences of FBIH
2003-05-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3555
10.17305/bjbms.2003.3555
Biomolecules and Biomedicine; Vol. 3 No. 2 (2003); 46-55
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3555/1069
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3557
2020-07-30T10:45:00Z
bjbms:REV
driver
Artificial creation of genetically identical individuals--reproductive cloning
Berberović, Ljubomir
artificial creation
genetically identical individuals
reproductive cloning
cloning
During the second half of the previous century, biologists were continuously searching for the answers to the questions about the creation of genetically identical individuals. From the very first ideas (Spemann, 1938) and the early reports on the attempts and successes in the reproductive cloning (Briggs and King, 1952; Stewart et al., 1958) to the recent news about the first cloned baby birth (published informally at the end of 2002), that topic gathered a significant scientific and non-scientific attention. All assertions about human cloning resounded as a sensation and made a particular public unrest, even though it was in fact an operation based on the existence of already well known scientific postulations, theories and experimental results. In spite of whether human individuals were cloned or not (many scientists expressed serious reserves regarding the above mentioned news), a wider public interest in cloning, its importance and procedures and a new technology practical possibilities increased significantly.
Association of Basic Medical Sciences of FBIH
2008-02-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3557
10.17305/bjbms.2003.3557
Biomolecules and Biomedicine; Vol. 3 No. 1 (2003); 5-17
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3557/1071
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3572
2020-07-30T10:46:02Z
bjbms:REV
driver
Dossier for marketing authorization in the European union
Todić, Maida
marketing authorization
application dossier
domestic laws
Extensive and complete documentation must be presented for marketing authorization of a medicinal product in the EU. Presented documentation should prove quality, safety and efficacy of the medicinal product. It is ensured that the applicant supplies the authorities with complete information. The legislation in Federation of Bosnia and Herzegovina has also taken more steps towards those European directions.
The presentation and content of the dossier in the European Union has been redefined. The “old” EU format will be replaced with the Common Technical Document (EU CTD format) agreed in 2000, within the International Conference on Harmonization framework. These two formats are intended to coexist during the transition period until July 2003. The CTD is an internationally agreed upon format for the preparation of a well structured presentation for applications to be submitted to regulatory authorities in the three ICH regions of Europe, US and Japan.
Association of Basic Medical Sciences of FBIH
2003-02-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3572
10.17305/bjbms.2003.3572
Biomolecules and Biomedicine; Vol. 3 No. 1 (2003); 56-60
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3572/1080
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3573
2020-07-30T10:46:52Z
bjbms:REV
driver
Experimental design - basic considerations
Vranić, Edina
experimental design
experimentation
fluidized bed
Experimental design is a critically important tool for improving the performance of a manufacturing process. It has also extensive application in the development of new processes. It is important to investigate all factors that may be of importance and to not be overly influenced by past experience, particularly when we are in the early stages of experimentation or when the process is not very mature.
Association of Basic Medical Sciences of FBIH
2003-02-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3573
10.17305/bjbms.2003.3573
Biomolecules and Biomedicine; Vol. 3 No. 1 (2003); 62-64
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3573/1081
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3580
2020-08-20T23:29:32Z
bjbms:REV
driver
Mitochondrial medicine - a key to solve pathophysiology of 21 century diseases
Kiseljaković, Emina
Jadrić, Radivoj
Hasić, Sabaheta
Ljuboja, Lorenka
Radovanović, Jovo
Kulenović, Husein
Winterhalter-Jadrić, Mira
mitochondria
mtDNA
mitochondrial diseases
Over the past 13 years mitochondrial defects have been involved in wide variety of degenerative diseases - Parkinson disease, Alzheimer dementia, arteriosclerosis, ageing and cancer. Mitochondria are believed to control apoptosis or programmed cell death. Disturbance in mitochondrial metabolism has also been implicated in many common diseases such as congestive hart failure, diabetes and migraine. Scientific investigations have showed complexities in mitochondrial genetics, but at the same time, pathophysiology of mitochondrial diseases is still enigma. Mitochondria and their DNAs are opening the era of "mitochondrial medicine". What we today call "a mitochondrial medicine" is only a part of the whole panorama of diseases based on disordered mitochondrial function.
Association of Basic Medical Sciences of FBIH
2008-02-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3580
10.17305/bjbms.2002.3580
Biomolecules and Biomedicine; Vol. 2 No. 1-2 (2002); 46-48
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3580/1088
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3580/1265
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3581
2020-07-30T10:53:43Z
bjbms:REV
driver
Mathematical methods for quantification and comparison of dissolution testing data
Vranić, Edina
Mehmedagić, Aida
Hadžović, Sabira
dissolution testing
difference factor
similarity factor
quantification
comparison
solid dosage forms
In recent years, drug release/dissolution from solid dosage forms has been the subject of intense and profitable scientific developments. Whenever a new solid dosage form is developed or produced, it is necessary to ensure that drug dissolutionoccurs in an appropriate manner. The pharmaceutical industry and the registration authorities do focus, nowadays, on drug dissolution studies. The quantitative analysis of the values obtained in dissolution/release tests is easier when mathematicalformulas that express the dissolution results as a function of some of the dosage forms characteristics are used. This work discusses the analysis of data obtained for dissolution profiles under different media pH conditions using mathematical methodsof analysis described by Moore and Flanner. These authors have described difference factor (f1) and similarity factor (f2), which can be used to characterise drug dissolution/release profiles. In this work we have used these formulas for evaluation of dissolution profiles of the conventional tablets in different pH of dissolution medium (range of physiological variations).
Association of Basic Medical Sciences of FBIH
2002-02-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3581
10.17305/bjbms.2002.3581
Biomolecules and Biomedicine; Vol. 2 No. 1-2 (2002); 49-52
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3581/1089
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3581/1266
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3585
2020-07-30T10:54:18Z
bjbms:REV
driver
Transcranial Doppler sonography as diagnostic method
Đelilović-Vranić, Jasminka
cerebrovascular disease (CVB)
Transcranial Doppler Sonography (TCD)
Having in mind the fact that cerebrovascular disease (CVB) takes today in medicine, in spite of diagnostic and therapeutic modernisation, the third place of mortality causes in the world (behind cordial and malignant diseases, but in front of depressions), and the second place of invalidity cause (right after trauma) as well as the second place of dementia cause (after Alzheimer disease), it urges primary prophylaxis. Developing countries, but before all countries of East and Middle Europe, where is our country, are highly risked areas where CV disease has trend of incidence and total frequency increase. In the neighbouring Croatia today CV disease is at the first place of mortality causes. In the world today 5 million people annually suffer CV disease, in Europe about 700.000, but frequency of suffering on Balkan is about 5 prom. Age of CV disease effecting unfortunately moved towards young age, and today 49% of effected by CV disease are of 46 to 59 years of age. Early detection and treatment of risk factors (before hypertension, smoking, diabetes mellitus, hyperlipidaemia, stress and physical non-activities) are the first aspect of CV disease prophylaxis. Together with this aspect of primary prophylaxis is early detection of complications of mentioned risk factors on the walls of blood vessels, before all changing in sense of arteriosclerosis, with consequence of disorder of cerebral haemodynamics. With that objective - verification of circulator and total haemodynamic disorders, there is obvious disclose of non-invasive diagnostic methods, and one of them is Transcranial Doppler Sonography(TCD). TCD is method comfortable for patient, reliable and rather precise, dynamic, and can be repeated several times, without side effects and in comparison with others rather cheap.
Association of Basic Medical Sciences of FBIH
2002-02-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3585
10.17305/bjbms.2002.3585
Biomolecules and Biomedicine; Vol. 2 No. 1-2 (2002); 66-70
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3585/1093
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3585/1272
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
oai:ojs2.www.bjbms.org:article/3717
2020-12-27T09:57:16Z
bjbms:REV
driver
Genetic secrets of long-term glioblastoma survivors
Jovčevska, Ivana
Glioblastoma
genetics
IDH
MGMT
chromosome 1p/19q
long term survival
extreme survivors
Glioblastomas are the most aggressive and lethal primary astrocytic tumors of the central nervous system. They account for 60% to 70% of all gliomas and the majority are diagnosed in Caucasian male patients at advanced age. Genetic analyses of glioblastoma show a great intra- and inter-tumor heterogeneity, which opens up a debate about its cellular origin. Different types of brain cells, including astrocytes, neural stem cells, oligodendrocyte precursor cells and glioblastoma stem cells are proposed to have a role in tumor initiation and spreading; however, data is still inconclusive. Due to short life expectancy, long-term glioblastoma survivors are defined as patients who live longer than two years post-diagnosis. Extreme survivors, living 10 years or more after diagnosis, comprise less than 1% of all patients. Molecular testing indicates genetic differences between short- and long-term survivors with glioblastoma. The most informative are IDH1/2 gene mutations and MGMT promoter methylation, which are associated with a better response to standard clinical care. Moreover, a decreased expression of the CHI3L1, FBLN4, EMP3, IGFBP2, IGFBP3, LGALS3, MAOB, PDPN, SERPING1 and TIMP1 genes has been associated with prolonged survival. In addition, emerging evidence suggests the role of different microRNAs in predicting patient survival. Other factors that may affect the survival of glioblastoma patients include clinical/demographic characteristics such as seizures at presentation, age at diagnosis, and the extent of surgical resection. Because of the small number of long-term survivors with glioblastoma, comparative studies on genetic differences between short- and long-term survivors are challenging. To improve patient management and clinical outcomes, a thorough “omics” approach is necessary for identifying differences between short- and long-term survivors with glioblastoma.
Association of Basic Medical Sciences of FBIH
2019-05-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
application/pdf
text/xml
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3717
10.17305/bjbms.2018.3717
Biomolecules and Biomedicine; Vol. 19 No. 2 (2019); 116-124
2831-090X
2831-0896
eng
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3717/1118
https://www.bjbms.org/ojs/index.php/bjbms/article/view/3717/1774
Copyright (c) 2018 Bosnian Journal of Basic Medical Sciences
7b886a628dd023ee12efc78f628f8595