Serum C-Reactive Protein Concentration and Measures of Adiposity in Patients With Type 2 Diabetes Mellitus

Asija Začiragić; Jasminko Huskić; Almira Hadžović-Džuvo; Amina Valjevac; Nesina Avdagić; Nedžad Mulabegović

doi:10.17305/bjbms.2007.3021

Authors

Asija Začiragić Institute of Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
Jasminko Huskić Institute of Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
Almira Hadžović-Džuvo Institute of Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
Amina Valjevac Institute of Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
Nesina Avdagić Institute of Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
Nedžad Mulabegović Institute of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Sarajevo

DOI:

https://doi.org/10.17305/bjbms.2007.3021

Keywords:

serum C-reactive protein, adiposity, type 2 diabetes mellitus

Abstract

We investigated serum concentration of C-reactive protein (CRP) and measures of adiposity in 30 patients with type 2 diabetes mellitus (15 male, 15 female) and 30 age and sex-matched apparently healthy subjects.

CRP concentration was determined by laser nephelometry (BN II Analyzer) and CardioPhase high-sensitivity CRP (DADE BEHRING) was used as reagent which consists of polystyrene particles coated with mouse monoclonal antibodies to CRP.

Results have shown that serum CRP concentration in patients with type 2 diabetes mellitus was statistically significantly higher compared to control group of healthy subjects (p<0,05). Body mass index (BMI) correlated significantly with serum concentration of CRP in patients with type 2 diabetes mellitus (r=0,614; p<0,001). Statistically significant positive correlation was also found between waist to hip ratio and serum CRP concentration in patients with type 2 diabetes mellitus (r=0,426; p<0,05).

Elevated serum CRP concentration in patients with type 2 diabetes mellitus is probably caused by the presence of chronic low-grade inflammation in these patients. It is possible that determined increase of CRP concentration reflects activation of innate immune system components in patients with type 2 diabetes mellitus. Implications of established association between measures of adiposity and serum CRP level in type 2 diabetes mellitus remain unclear.