Analysis of manganese superoxide dismutase (MnSOD: Ala-9Val) and glutathione peroxidase (GSH-Px: Pro 197 Leu) gene polymorphisms in mood disorders.

  • Birgül Elbozan Cumurcu Department of Psychiatry, Faculty of Medicine, İnönü University, Turgut Özal Medical Center
  • Huseyin Ozyurt Department of Biochemistry, Faculty of Medicine, Gaziosmanpaşa University
  • Omer Ates Department of Medical Biology, Faculty of Medicine, Gaziosmanpaşa University
  • Isil Gogcegoz Gul Department of Psychiatry, Siverek State Hospital
  • Suleyman Demir Department of Psychiatry, Diyarbakir Training and Research Hospital
  • Rifat Karlıdag Department of Psychiatry, Faculty of Medicine, İnönü University, Turgut Özal Medical Center
Keywords: bipolar I disorder, major depressive disorder, manganese superoxide dismutase, glutathione peroxidase, polymorphism

Abstract

We investigated the etiopathogenetic role of manganese superoxide dismutase (MnSOD) (Ala-9Val) and glutathione peroxidase (GSH-Px) (Pro 197 Leu) gene polymorphisms in patients diagnosed with major depressive disorder (MDD) and bipolar I disorder (BD). Eighty patients with MDD, 82 patients with BD (total 162 patients) and 96 healthy controls were enrolled in this study and genotyped using a Real Time-Quantitative Polymer Chain Reaction (RT-qPCR)-based method. The patients with BD and MDD and the controls had a similar distribution of the genotypes and alleles in the Ala-9Val MnSOD gene polymorphism. Comparison of the MDD group and control group regarding the Pro197 Leu GSH-Px gene polymorphism revealed similar genotype distribution but different allele distribution. The BD group and control group were similar both for genotypes and for alleles when compared regarding the Pro 197 Leu GSH-Px gene polymorphism. The combined analysis (MDD plus BD) also failed to find any association between the Ala-9Val MnSOD and Pro 197 Leu GSH-Px gene polymorphism. Although small statistical power of the current study the significant difference between patients with depression and the control group for the Pro 197 Leu GSH-Px polymorphism indicates that the distribution of these alleles may have a contribution in the physiopathogenesis of depression. One of the limitation of the current study is that the sample size is too small. Understanding of the exact role of Pro 197 LeuGSH-Px polymorphism in the development of depression needs to further studies with more sample size and high statistical power.

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Published
2013-05-20
How to Cite
1.
Elbozan Cumurcu B, Ozyurt H, Ates O, Gogcegoz Gul I, Demir S, Karlıdag R. Analysis of manganese superoxide dismutase (MnSOD: Ala-9Val) and glutathione peroxidase (GSH-Px: Pro 197 Leu) gene polymorphisms in mood disorders. Bosn J of Basic Med Sci [Internet]. 2013May20 [cited 2019Oct.15];13(2):109-13. Available from: http://www.bjbms.org/ojs/index.php/bjbms/article/view/2390
Section
Molecular Biology