Association between Opioid Receptor mu 1 (OPRM1) Gene Polymorphisms and Tobacco and Alcohol Consumption in a Spanish Population

  • Francesc Francès Department of Preventive and Legal Medicine, School of Medicine, University of Valencia, Valencia
  • Olga Portolés Department of Preventive and Legal Medicine, School of Medicine, University of Valencia, Valencia
  • Ana Castelló Department of Preventive and Legal Medicine, School of Medicine, University of Valencia, Valencia
  • Jose Antonio Costa Athenea Health Center, Aldaia
  • Fernando Verdú Department of Preventive and Legal Medicine, School of Medicine, University of Valencia, Valencia
Keywords: Tobacco, Alcohol, Drug abuse, Genetic polymorphism

Abstract

Evidence gained from animals and humans suggests that the encephalic opioid system might be involved in the development of drug addiction through its role in reward. Our aim is to assess the influence of genetic variations in the opioid receptor mu 1 on alcohol and tobacco consumption in a Spanish population. 763 unrelated individuals (465 women, 298 men) aged 18-85 years were recruited between October 2011 and April 2012. Participants were requested to answer a 35-item questionnaire on tobacco and alcohol consumption, as well as to complete the AUDIT and Fagerström tests. Individuals were genotyped for three polymorphisms in the opioid receptor mu 1 (OPRM1) gene, using a TaqMan® protocol. In males, the rs10485057 polymorphism was associated with total pure ethanol intake and with the risk of being an alcohol consumer. Also, this polymorphism was significantly associated with higher Fagerström scores. Rs1799971 had a different influence on adaptive and maladaptive patterns of alcohol use. Despite the limited sample size, our study might enrich current knowledge on patterns of alcohol use, because it encompasses both extreme and adaptive phenotypes, providing thus a wider perspective on this subject.

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Author Biographies

Francesc Francès, Department of Preventive and Legal Medicine, School of Medicine, University of Valencia, Valencia
Contracted Professor of Legal and Forensic Medicine
Olga Portolés, Department of Preventive and Legal Medicine, School of Medicine, University of Valencia, Valencia
Contracted Professor of Epidemiology and Public Health
Ana Castelló, Department of Preventive and Legal Medicine, School of Medicine, University of Valencia, Valencia

Contracted Professor of Legal and Forensic Medicine 

Jose Antonio Costa, Athenea Health Center, Aldaia
Family Phisician. PhD
Fernando Verdú, Department of Preventive and Legal Medicine, School of Medicine, University of Valencia, Valencia
Titular Professor of Legal and Forensic Medicine

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Published
2015-04-25
How to Cite
1.
Francès F, Portolés O, Castelló A, Costa JA, Verdú F. Association between Opioid Receptor mu 1 (OPRM1) Gene Polymorphisms and Tobacco and Alcohol Consumption in a Spanish Population. Bosn J of Basic Med Sci [Internet]. 2015Apr.25 [cited 2019Nov.15];15(2):31-6. Available from: http://www.bjbms.org/ojs/index.php/bjbms/article/view/243
Section
Molecular Biology