Risk Factors for Development of Cardiovascular Complications in Patients with Chronic Renal Disease and Diabetic Nephropathy

  • Amra Mataradžija Clinic for Nephrology, University of Sarajevo Clinics Centre
  • Halima Resić Clinic for Hemodialysis, University of Sarajevo Clinics Centre
  • Senija Rašić Clinic for Nephrology, University of Sarajevo Clinics Centre
  • Nihad Kukavica Clinic for Hemodialysis, University of Sarajevo Clinics Centre
  • Fahrudin Masnić Clinic for Hemodialysis, University of Sarajevo Clinics Centre
Keywords: Diabetes mellitus, chronic renal disease, cardiovascular complications

Abstract

Introduction:

Cardiovascular diseases are the most frequent causes of morbidity and mortality in patients with chronic renal disease. The aim of our paper is to evaluate the risk factors of cardiovascular complications in patients with various stages of chronic renal disease (CRD), with or without diabetes mellitus (DM).

Patients and methods:

The study included 98 patients with different stages of the CRD, with creatinine clearance <60 ml/min/1,73m2, and laboratory parameters monitored: homocysteine, BNP, cholesterol, LDL, HDL, HbA1c, Body Mass Index (BMI). First group comprised 49 patients with DM, age 50-82 years, M 28/F 21. Second group comprised 49 patients without DM, age 35-80 years, M 18/F 31. The IMT (intima media thickness) was measured by B-mode ultrasonography, and all patients had echocardiography examination done by 2D Doppler ultrasonography.

Results:

The IMT values in diabetic patients had statistically significant positive correlation with homocysteine values of r=0,9393, p<0,034, and cholesterol r=0,289, p<0,05, compared to non-diabetics. A significant negative correlation was found between the ejection fraction (EF) and BMI in both groups, more prominent in non-diabetics r=0,289, p<0,044 (diabetics r=0,162, p>0,05). 47,4% of diabetics had arteriosclerotic changes on carotid arteries, 8,5% had stenosis of ACC, and 22,0% had rhythm abnormalities on ECG. A positive correlation between IMT and BMI was found in diabetics, but was not statistically significant r=0,111, p>0,05. In the diabetics group a significantly higher (p<0,05) values of BNP, HbA1c, proteinuria, BMI, and cholesterol were found, and significantly lowered EF (p<0,0001).

Conclusion:

Risk factors for cardiovascular complications in patients with DM are various, and the most pronounced significance was found in the values of homocystein, BNP and cholesterol.

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Published
2010-04-20
How to Cite
1.
Mataradžija A, Resić H, Rašić S, Kukavica N, Masnić F. Risk Factors for Development of Cardiovascular Complications in Patients with Chronic Renal Disease and Diabetic Nephropathy. Bosn J of Basic Med Sci [Internet]. 2010Apr.20 [cited 2019Nov.15];10(1):S44-50. Available from: http://www.bjbms.org/ojs/index.php/bjbms/article/view/2648
Section
Translational and Clinical Research

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