Biochemical Evaluation of the Therapeutic Effectiveness of Honey in Oral Mucosal Ulcers

Nergiz Yılmaz; Özlem Nisbet; Cevat Nisbet; Gözlem Ceylan; Fatih Hoşgör; Ö.Doğu Dede

doi:10.17305/bjbms.2009.2781

Authors

Nergiz Yılmaz Department of Oral and Maxillofacial Surgery, Dental Faculty, Ondokuz Mayis University
Özlem Nisbet Department of Surgery, Veterinerian Faculty, Ondokuz Mayis University
Cevat Nisbet Department of Biochemistry, Veterinerian Faculty, Ondokuz Mayis University
Gözlem Ceylan Department of Prosthodontics, Dental Faculty, Ondokuz Mayis University
Fatih Hoşgör Department of Oral and Maxillofacial Surgery, Dental Faculty, Ondokuz Mayis University
Ö.Doğu Dede Department of Prosthodontics, Dental Faculty, Ondokuz Mayis University

DOI:

https://doi.org/10.17305/bjbms.2009.2781

Keywords:

honey, oral ulcers, hydroxy pyroline

Abstract

The aim of this study was to describe and quantify the therapeutic value of honey in oral mucosal ulcers healing in comparison with Glyceroloxytriester (TGO). We also aimed to biochemically evaluate the healing effects of honey which had been collected from the Blacksea region flora on mucosal ulcers resulting in material loss.

Thirty wistar rats (240±30 g) were enrolled in this study. Excisional wounds were performed in all rats for animal oral mucosal ulcer model. They were randomly allocated to three groups: group 1 was treated with Apitherapeutic agent or honey (0,1 ml, 2x1), group 2 was treated with TGO (0,1ml, 2x1) locally, Group 3 served as the control group.

Following the surgical procedure on day 7, biopsy specimens were taken from right buccal mucosa and on day 14 biopsy specimens were taken from left bucal mucosa in all rats. Afterwards, hydroxy pyroline levels were measured. Data were analyzed statistically

There was no statistically significant difference between Group 1 and 2, and also between Group 2 and 3, but there was statistically significant difference between Group 1 and 3 on day 7. There was no statistically significant difference between Group 1, 2 and 3 on day 14.