The Role of Pineal Gland and Exogenous Melatonin on the Irradiation Stress Response of Suprarenal Gland

  • Selma Aličelebić Institute for Histology and Embryology, Faculty of Medicine, University of Sarajevo
  • Zakira Mornjaković Institute for Histology and Embryology, Faculty of Medicine, University of Sarajevo
  • Irfan Šuško Institute for Histology and Embryology, Faculty of Medicine, University of Sarajevo
  • Esad Ćosović Institute for Histology and Embryology, Faculty of Medicine, University of Sarajevo
  • Amira Beganović-Petrović Institute for Histology and Embryology, Faculty of Medicine, University of Sarajevo
Keywords: melatonin, suprarenal gland, pinealectomy, total irradiation

Abstract

Pineal gland has and antistressogenic role. Its main hormone, melatonin, has radio protective effect on endocrine and other dynamic tissues. In our previous study, we have shown that pinealectomy changes the behavior of suprarenal gland in totally irradiated rats. The aim of this study is to evaluate the effect of exogenous melatonin on suprarenal gland of rats with or without pineal gland. Four months after pinealectomy (experimental group) or shampinealectomy (control group), adult Wistar male rats were daily treated with 0,2 mg of melatoninintraperitoneally, during two weeks. Thereafter, all animals were totally irradiated with 8 Gy of Gamma rays produced from Cobalt 60. Animals who survived were sacrificed on the 17(th) post irradiation day. Qualitative and quantitative characteristics of the suprarenal gland were studied using histological methods. The results show that exogenous melatonin had protective role on suprarenal gland in totally irradiated rats and that those effects were more pronounced in the presence of pineal gland.

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Published
2006-11-20
How to Cite
1.
Aličelebić S, Mornjaković Z, Šuško I, Ćosović E, Beganović-Petrović A. The Role of Pineal Gland and Exogenous Melatonin on the Irradiation Stress Response of Suprarenal Gland. Bosn J of Basic Med Sci [Internet]. 2006Nov.20 [cited 2019Jun.17];6(4):18-1. Available from: http://www.bjbms.org/ojs/index.php/bjbms/article/view/3112
Section
Pathology

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