Influence of Two Different Types of Cardioplegia on Hemodilution During and After Cardiopulmonary Bypass, Postoperative Chest-Drainage Bleeding and Consumption of Donor Blood Products

  • Mirsad Kacila Heart Center Sarajevo, University of Sarajevo Clinics Center
  • Katrin Schäfer Heart Center Sarajevo, University of Sarajevo Clinics Center
  • Esad Subašić Heart Center Sarajevo, University of Sarajevo Clinics Center
  • Nermir Granov Heart Center Sarajevo, University of Sarajevo Clinics Center
  • Edin Omerbašić Heart Center Sarajevo, University of Sarajevo Clinics Center
  • Faida Kučukalić Heart Center Sarajevo, University of Sarajevo Clinics Center
  • Ermina Selimović-Mujčić Heart Center Sarajevo, University of Sarajevo Clinics Center
Keywords: cardiopulmonary bypass, myocardial protection, cardioplegia, postoperative bleeding, hemodilution

Abstract

The aim of this study is to compare the effects of colloidal cardioplegia and blood cardioplegia in patients who underwent cardiac surgical procedures with cardiopulmonary bypass, and to evaluate their influence on hemodilution, bleeding and consumption of donor blood productsin a retrospective clinical study. 100 male patients who underwent cardiac surgical procedure were divided into two groups: 50 patients were administered intermittent normotherm or mild hypotherm (34 degrees C) Calafiore blood cardioplegia with potassium chloride 14,9%; 50 patients were administered one initial doses of cold Kirsch - solution followed from intermittent cold colloidal cardioplegia using hydroxyethyl starch (HES 450/0,7). Hemoglobin values after the first dose of cardioplegia were significantly lower in the HES-group than in the Calafiore- group). After the first dose of cardioplegia platelets count was lower in the HES-group than in the Calafiore-group. Hemoglobin and hematocrit values 24h postoperative were lower in the HES-group than in the Calafiore-group. There was no difference in chest-drainagebleeding 12h and 24h postoperative between the groups. The consumption of donor erythrocyte concentrate and fresh frozen plasma was significantly higher in the HES-than in the Calafiore- group. The choice of either colloidal or blood cardioplegia does not influence the postoperative chest-drainage bleeding. The results suggest that high molecular colloidal cardioplegia with HES-solution is associated with higher hemodilution during and after cardiopulmonary bypass and significantly increases the consumption of donor blood products.

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Published
2006-08-20
How to Cite
1.
Kacila M, Schäfer K, Subašić E, Granov N, Omerbašić E, Kučukalić F, Selimović-Mujčić E. Influence of Two Different Types of Cardioplegia on Hemodilution During and After Cardiopulmonary Bypass, Postoperative Chest-Drainage Bleeding and Consumption of Donor Blood Products. Bosn J of Basic Med Sci [Internet]. 2006Aug.20 [cited 2019Aug.20];6(3):48-3. Available from: http://www.bjbms.org/ojs/index.php/bjbms/article/view/3144
Section
Translational and Clinical Research

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