Embryogenesis of the rat telencephalon--a morphologic and stereologic analysis

  • Selma Aličelebić Institute of Histology and Embryology, University of Sarajevo, School of Medicine
  • Đurđica Grbeša Institute of Epidemiology and Biostatistics, Faculty of Medicine, University of Sarajevo
Keywords: rat telencephalon, development, stereology

Abstract

Comparative researches of borderline between telencephalon neuroepithelium and its surrounding mesenchyme in successive early developing stages lack in literature. The aim of this investigation was to carry out systematic morphologic and stereologic analyses of rattelencephalon in early developmental stages. We analysed semithin (1 microm) serial sections of rat embryonic brain from the 12th (E12) to the 15th (E15) day of gestation. The surface densities (SV) of an external mesenchymal surface, an internal mesenchymal surface and a neuroepithelial (ventricular) surface were examined stereologically and compared. The surface density of the external mesenchymal surface was the biggest at E12 (4,05 mm-1) and the least at E15 (1,87 mm-1)-p<0,0005. The surface density of the internal mesenchymal surface was the biggest at E12 (4,02 mm-1) and the least at E15 (2,69 mm-1)-p<0,0005. The surface density of the internal neuroepithelial surface was the biggest at E12 (3,31 mm-1) and the least at E15 (2,01 mm-1)-p<<0,0005. Our stereological examines give objective numerical proof of significant morphogenetic changes in telencephalon shape described by morphologicanalyses. The major advantage of stereological methods is the possibility to carry out the estimation procedures in specified, well-defined brain regions or layers.

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Published
2005-05-20
How to Cite
1.
Aličelebić S, Grbeša Đurđica. Embryogenesis of the rat telencephalon--a morphologic and stereologic analysis. Bosn J of Basic Med Sci [Internet]. 2005May20 [cited 2019Nov.15];5(2):59-4. Available from: http://www.bjbms.org/ojs/index.php/bjbms/article/view/3286
Section
Anatomy