Inflammatory cells in perivascular adipose tissue and the integrity of the tunica media in atherosclerotic coronary arteries

  • Ruda Zorc-Pleskovič Institute of Histology and Embryology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia; International Center for Cardiovascular Diseases MC Medicor d.d., Izola, Slovenia https://orcid.org/0000-0001-8208-4663
  • Marjeta Zorc International Center for Cardiovascular Diseases MC Medicor d.d., Izola, Slovenia https://orcid.org/0000-0001-8208-4663
  • Dušan Šuput Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia; Center for Clinical Physiology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia https://orcid.org/0000-0003-4031-7267
  • Aleksandra Milutinović Institute of Histology and Embryology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia https://orcid.org/0000-0003-4142-4814
Keywords: Perivascular adipose tissue, PVAT, atherosclerosis, coronary arteries, endarterectomy, CAD, coronary artery disease, inflammatory infiltration

Abstract

Obstructive coronary artery disease (CAD) is characterized by inflammation within the atherosclerotic coronary arteries. Infiltration of inflammatory cells into muscular media can lead to remodeling and weakening of the arterial wall. We examined the relationship between inflammatory infiltration in perivascular adipose tissue (PVAT), state of the external elastic membrane, and the intensity of inflammatory infiltration in the tunica media of coronary arteries obtained by endarterectomy from symptomatic patients with diffuse CAD. We analyzed endarterectomy sequesters from 22 coronary arteries that contained the intima, media, a part of the adventitia, and PVAT in at least one part of the sequester. The coronary arteries were divided into two groups according to the presence or absence of inflammatory infiltration in PVAT. Staining with hematoxylin-eosin and by the Movat's method showed atherosclerotic changes in the intima and media. Immunohistochemistry (anti-leukocyte common antigen [LCA] antibody) was used for the detection of leukocytes. We found a significant positive correlation between inflammatory infiltration in PVAT and preservation of the external elastic membrane of coronary arteries. Furthermore, we found a significant negative correlation between inflammatory infiltration in PVAT and the intensity of inflammatory infiltration in the media. It seems that the integrity of the external elastic membrane and the proinflammatory properties of PVAT restrain inflammatory cells within PVAT. Both effects may prevent the migration of inflammatory cells into the media and delay the development of CAD.

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Published
2019-09-27
How to Cite
1.
Zorc-Pleskovič R, Zorc M, Šuput D, Milutinović A. Inflammatory cells in perivascular adipose tissue and the integrity of the tunica media in atherosclerotic coronary arteries. Bosn J of Basic Med Sci [Internet]. 2019Sep.27 [cited 2019Dec.8];00. Available from: http://www.bjbms.org/ojs/index.php/bjbms/article/view/4409
Section
Pathology