Prediction of mortality in patients with secondary pulmonary embolism based on primary admission indication: A short communication

Authors

  • Martin J. Ryll Faculty of Medicine, Ludwig Maximilian University of Munich, Munich, Germany https://orcid.org/0009-0002-4245-9461
  • Toby N. Weingarten Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA
  • Juraj Sprung Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA

DOI:

https://doi.org/10.17305/bb.2024.10481

Keywords:

Pulmonary embolism (PE), intensive care unit (ICU), critical care, mortality, Pulmonary Embolism Severity Index (PESI), simplified PESI (sPESI), modified sPESI (ICU-sPESI), Acute Physiology and Chronic Health Evaluation-IV (APACHE-IV), prediction of mortality

Abstract

We evaluated the prediction of mortality in patients admitted to the intensive care unit (ICU) who subsequently developed a pulmonary embolism (PE) (i.e., secondary PE) using three PE-specific scores, the Pulmonary Embolism Severity Index (PESI), simplified PESI (sPESI), and modified sPESI (ICU-sPESI) and compared them to the gold standard for the assessment of ICU all-cause mortality, the Acute Physiology and Chronic Health Evaluation-IV (APACHE-IV). All critical care admission indications were grouped into four major categories: post-operative, cardiovascular, infectious (sepsis), and other. The APACHE-IV displayed better discriminative ability to predict in-hospital mortality than the PESI and ICU-sPESI, but these two scores still performed fair for the ICU admissions related to postoperative, cardiovascular, and other admission types. Meanwhile, the sPESI displayed poor predictive performance across all four admission categories. Notably, discriminatory performance for patients with an infection-related admission was consistently low regardless of which score was used.

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Prediction of mortality in patients with secondary pulmonary embolism based on primary admission indication

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Published

23-03-2024

Data Availability Statement

For access to the eICU-CRD dataset, please review https://eicu-crd.mit.edu/. The code for data extraction and data analysis can be found at https://github.com/RyllMartin/eICU_ICU_sPESI_validation_secondary_PE.

Issue

Section

Short Communication

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How to Cite

1.
Prediction of mortality in patients with secondary pulmonary embolism based on primary admission indication: A short communication. Biomol Biomed [Internet]. 2024 Mar. 23 [cited 2024 Jul. 23];:941–945. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/10481