Artificial intelligence-assisted measurements of coronary computed tomography angiography parameters such as stenosis, flow reserve, and fat attenuation for predicting major adverse cardiac events in patients with coronary arterial disease

Authors

  • Cheng Luo Department of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China https://orcid.org/0009-0003-2200-8652
  • Liang Mo Department of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
  • Zisan Zeng Department of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
  • Muliang Jiang Department of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China https://orcid.org/0000-0002-1563-9101
  • Bihong T. Chen Department of Diagnostic Radiology, City of Hope National Medical Center, Duarte, California, USA

DOI:

https://doi.org/10.17305/bb.2024.10497

Keywords:

Coronary computed tomography angiography (CCTA), artificial intelligence (AI), coronary artery disease (CAD), major adverse cardiac events (MACE)

Abstract

Advancements in artificial intelligence (AI) offer promising tools for improving diagnostic accuracy and patient outcomes in cardiovascular medicine. This study explores the potential of AI-assisted measurements in enhancing the prediction of major adverse cardiac events (MACE) in patients with coronary artery disease (CAD). We conducted a retrospective cohort study involving patients diagnosed with CAD who underwent coronary computed tomography angiography (CCTA). Participants were classified into MACE and non-MACE groups based on their clinical outcomes. Clinical characteristics and AI-assisted measurements of CCTA parameters, including CT-derived fractional flow reserve (CT-FFR) and fat attenuation index (FAI), were collected. Both univariate and multivariable logistic regression analyses were performed to identify independent predictors of MACE, which were used to build predictive models. Statistical analyses revealed three independent predictors of MACE: severe stenosis, CT-FFR ≤ 0.8, and mean FAI (P < 0.05). Seven predictive models incorporating various combinations of these predictors were developed. The model combining all three predictors demonstrated superior performance, as evidenced by the receiver operating characteristic (ROC) curve, with an area under the curve (AUC) of 0.811 (95% confidence interval [CI] 0.774 – 0.847), a sensitivity of 0.776, and a specificity of 0.726. Our findings suggest that AI-assisted CCTA analysis, particularly using fractional flow reserve (FFR) and FAI, could significantly improve the prediction of MACE in patients with CAD, thereby potentially aiding clinical decision making.

Citations

Downloads

Download data is not yet available.
AI-assisted measurements of coronary computed tomography angiography parameters such as stenosis, flow reserve and fat attenuation for predicting major adverse cardiac events in patients with coronary arterial disease

Downloads

Published

06-09-2024

Issue

Section

Research article

Categories

How to Cite

1.
Artificial intelligence-assisted measurements of coronary computed tomography angiography parameters such as stenosis, flow reserve, and fat attenuation for predicting major adverse cardiac events in patients with coronary arterial disease. Biomol Biomed [Internet]. 2024 Sep. 6 [cited 2024 Oct. 5];24(5):1407–1416. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/10497