Comparison of robotic, conventional, and endoscopic nipple-sparing mastectomy with immediate prosthetic breast reconstruction for breast cancer: A systematic review and meta-analysis

Authors

  • Na An Department of Breast Diseases, Weifang People's Hospital, Weifang City, Shandong Province, China
  • Wenjuan Wang Department of Breast Diseases, Weifang People's Hospital, Weifang City, Shandong Province, China
  • Dandan Dai Department of Breast Diseases, Weifang People's Hospital, Weifang City, Shandong Province, China
  • Fei Yuan Department of Breast Diseases, Weifang People's Hospital, Weifang City, Shandong Province, China
  • Yufeng Zhang Department of Breast Diseases, Weifang People's Hospital, Weifang City, Shandong Province, China

DOI:

https://doi.org/10.17305/bb.2025.11687

Keywords:

Breast cancer, robotic nipple-sparing mastectomy, RNSM, conventional / nipple-sparing mastectomy, CNSM, endoscope-assisted nipple-sparing mastectomy, ENSM, network meta-analysis

Abstract

In this network meta-analysis (NMA), we aimed to evaluate the relative efficacy of robotic nipple-sparing mastectomy (RNSM), conventional nipple-sparing mastectomy (CNSM), and endoscope-assisted nipple-sparing mastectomy (ENSM), each combined with immediate prosthetic breast reconstruction (IPBR), for the treatment of breast cancer. Relevant studies published up to June 15, 2024, were identified through searches of PubMed, Embase, the Cochrane Library, and Web of Science. Data extracted from these studies were analyzed using Stata 15.1 and the Gemtc 1.0.1 package in R 4.2.3. A Bayesian framework and a Markov Chain Monte Carlo model were employed to conduct the NMA. Additionally, a ranking chart was generated to compare the advantages and disadvantages of the surgical methods. Ten studies met the inclusion criteria and were included in the NMA. The results indicated that ENSM with immediate implant-based reconstruction was associated with a smaller incision compared to CNSM. RNSM combined with IPBR was linked to a lower incidence of total complications, Grade 3 complications, and nipple-areola complex necrosis than CNSM. Furthermore, RNSM with IPBR demonstrated a lower recurrence rate than CNSM. However, CNSM with IPBR showed better outcomes in terms of surgical time, hospital stay, and positive margin infiltration. In contrast, RNSM and ENSM, both combined with IPBR, outperformed CNSM in terms of incision length, complication rates, and recurrence outcomes.

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Comparison of robotic, conventional, and endoscopic nipple-sparing mastectomy with immediate prosthetic breast reconstruction for breast cancer: A systematic review and meta-analysis

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Published

21-04-2025

Issue

Section

Systematic review/Meta analysis

How to Cite

1.
Comparison of robotic, conventional, and endoscopic nipple-sparing mastectomy with immediate prosthetic breast reconstruction for breast cancer: A systematic review and meta-analysis. Biomol Biomed [Internet]. 2025 Apr. 21 [cited 2025 May 1];. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/11687