Vitamin D supplementation for tuberculosis prevention: A meta-analysis

Authors

  • Sheng Liu The Second Department of Infection, 900th Hospital of PLA Joint Logistic Support Force, Fuzhou, Fujian Province, China
  • Tianyu Lin The Second Department of Infection, 900th Hospital of PLA Joint Logistic Support Force, Fuzhou, Fujian Province, China
  • Yanyu Pan The Second Department of Infection, 900th Hospital of PLA Joint Logistic Support Force, Fuzhou, Fujian Province, China

DOI:

https://doi.org/10.17305/bb.2025.12527

Keywords:

Tuberculosis, Prevention, Vitamin D, Supplementation, Meta-analysis

Abstract

Vitamin D plays an important role in immune regulation, prompting interest in its potential for preventing tuberculosis. However, clinical findings regarding its protective effects against tuberculosis infection and disease remain inconsistent. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the impact of vitamin D supplementation on the prevention of tuberculosis infection and the progression to active tuberculosis. We searched PubMed, Embase, Cochrane Library, and Web of Science databases through January 2025. Eligible studies involved participants without active tuberculosis at baseline and reported outcomes related to tuberculosis. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a random-effects model. Subgroup and sensitivity analyses were conducted, and the certainty of evidence was evaluated using the GRADE approach. Six RCTs, involving 15,677 participants, met our inclusion criteria. Compared to placebo, vitamin D supplementation did not significantly reduce the risk of tuberculosis infection (5 RCTs; OR: 0.95; 95% CI: 0.79–1.14; p = 0.55) or the development of active tuberculosis (4 RCTs; OR: 0.77; 95% CI: 0.56–1.05; p = 0.10). The certainty of evidence was moderate for both outcomes. Subgroup analyses based on baseline vitamin D levels and duration of follow-up yielded consistent results. The incidence of serious adverse events was comparable between the vitamin D and placebo groups (OR: 1.02; 95% CI: 0.76–1.38; p = 0.87), and none of the serious events were attributed to vitamin D supplementation. In conclusion, vitamin D supplementation does not significantly reduce the risk of tuberculosis infection or progression to active tuberculosis, although it is safe and well tolerated.

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Vitamin D supplementation for tuberculosis prevention: A meta-analysis

Published

02-07-2025

Issue

Section

Systematic review/Meta analysis

Categories

How to Cite

1.
Vitamin D supplementation for tuberculosis prevention: A meta-analysis. Biomol Biomed [Internet]. 2025 Jul. 2 [cited 2025 Jul. 3];. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/12527