Development of a novel clinical prediction model for sepsis related mortality by combining NEWS, PIRO and lactate

Authors

  • Ozge Kurtkulagi Department of Internal Medicine, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey https://orcid.org/0000-0002-4162-5563
  • Ece Unal Cetin Department of Internal Medicine, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey
  • Fatih Kamis Department of Internal Medicine, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey
  • Murat Das Department of Emergency Medicine, Faculty of Medicine, Çanakkale Onsekiz Mart University School of Medicine, Çanakkale, Turkey
  • Esen Simsek Department of Anesthesiology and Reanimation, Faculty of Medicine, Çanakkale Onsekiz Mart University School of Medicine, Çanakkale, Turkey https://orcid.org/0009-0000-1663-1972
  • Ozgur Kurtkulagi Department of General Surgery, Çanakkale State Hospital, Çanakkale, Turkey
  • Adil Ugur Cetin Department of Internal Medicine, Çanakkale State Hospital, Çanakkale, Turkey https://orcid.org/0000-0002-2640-5386
  • Yavuz Beyazit Department of Gastroenterology, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey https://orcid.org/0000-0001-6247-2714

DOI:

https://doi.org/10.17305/bb.2025.12562

Keywords:

Sepsis prognosis, risk assessment, intensive care unit, blood lactate levels

Abstract

Prognostic assessment plays a crucial role in guiding therapeutic decision-making for patients with sepsis, particularly in intensive care settings. This study aimed to develop a multivariable model to predict 28-day mortality among intensive care unit (ICU) patients with sepsis by integrating serum lactate levels, the National Early Warning Score (NEWS), and the Predisposition, Infection, Response, and Organ Dysfunction (PIRO) score. Demographic information, clinical characteristics, and laboratory findings routinely collected at ICU admission were used to calculate the NEWS and PIRO scores for each patient. Patients were categorized as survivors or non-survivors based on their outcome. Both logistic regression and Cox proportional hazards models were applied for mortality prediction analysis. The final analysis included 205 patients diagnosed with sepsis (mean age: 73.6 ± 13.2 years; 53.2% male), of whom 109 died during hospitalization. Logistic regression analysis revealed that lactate, NEWS, and PIRO scores were independently associated with 28-day mortality. Combining lactate levels with NEWS and PIRO significantly enhanced mortality prediction, with the greatest accuracy observed when all three parameters were integrated. Pairwise analyses demonstrated that adding lactate to the base model significantly improved predictive accuracy (DBA: −0.103, p = 0.003), and incorporating lactate into a model already including NEWS further enhanced its predictive value (DBA: −0.042, p = 0.037). In conclusion, serum lactate measured at initial ICU admission provides valuable prognostic information for predicting 28-day mortality in sepsis patients. Furthermore, combining lactate levels with NEWS and PIRO scores substantially enhances the accuracy of mortality prediction in these patients.

Citations

Downloads

Download data is not yet available.
Development of a novel clinical prediction model for sepsis related mortality by combining NEWS, PIRO and lactate

Published

30-06-2025

How to Cite

1.
Development of a novel clinical prediction model for sepsis related mortality by combining NEWS, PIRO and lactate. Biomol Biomed [Internet]. 2025 Jun. 30 [cited 2025 Jul. 1];. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/12562