Evaluation of pulmonary artery pressure in patients with juvenile systemic lupus erythematosus (jSLE)

  • Amra Adrovic Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
  • Reyhan Dedeoglu Department of Pediatric Cardiology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
  • Sezgin Sahin Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
  • Kenan Barut Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
  • Aida Koka Department of Pediatric Cardiology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
  • Dicle Cengiz Department of Statistics, Istanbul Commerce University, Istanbul, Turkey
  • Funda Oztunc Department of Pediatric Cardiology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
  • Ozgur Kasapcopur Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
Keywords: Doppler echocardiography, juvenile systemic lupus erythematosus, pulmonary artery pressure, pulmonary artery hypertension, right ventricle, jSLE, PAH, PAP, PASP, mPAP

Abstract

Juvenile systemic lupus erythematosus (jSLE) is a chronic multisystemic autoimmune disease. Previous studies among adults have shown impaired right ventricular (RV) function in patients with SLE. Also, these patients may develop pulmonary artery hypertension (PAH), which is one of the most threatening complications of SLE. Nevertheless, studies on PAH among jSLE patients are still rare. The aim of this study was to assess the RV function in jSLE patients by Doppler echocardiography (Echo Doppler). We also estimated pulmonary artery systolic pressure (PASP) and mean pulmonary artery pressure (mPAP) in these patients. A total of 38 jSLE patients and 40 sex- and age-matched controls were retrospectively analyzed. All patients underwent combined M-mode, cross-sectional echo, and Doppler Echo examination. The RV function was significantly impaired in jSLE patients compared to controls. PASP and mPAP were normal in 37 out of 38 patients (97.37%), however, the mean values of PASP and mPAP were significantly higher in jSLE patients compared to controls (26.90 mmHg versus 21.71 mmHg and 12.63 mmHg versus 9.89 mmHg, respectively) [p < 0.05]. Only one patient (2.6 %) had elevated mPAP (60 mmHg). The right cardiac catheterization confirmed PAH in this patient. Although PAH was detected only in one patient, there was a marked increase of PAP in our jSLE patients. Overall, PASP and mPAP were significantly higher in jSLE patients compared to healthy controls. Prospective studies with ethnically diverse cohorts could give more insight on the relevance of PAP and PHT in patients with jSLE.

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Author Biographies

Amra Adrovic, Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
Department of Pediatric Rheumatology
Reyhan Dedeoglu, Department of Pediatric Cardiology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
Department of Pediatric Cardiology
Sezgin Sahin, Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
Department of Pediatric Rheumatology
Kenan Barut, Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
Department of Pediatric Rheumatology
Aida Koka, Department of Pediatric Cardiology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
Department of Pediatric Cardiology
Dicle Cengiz, Department of Statistics, Istanbul Commerce University, Istanbul, Turkey
Department of Statistics
Funda Oztunc, Department of Pediatric Cardiology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
Department of Pediatric Cardiology
Ozgur Kasapcopur, Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
Department of Pediatric Rheumatology

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Published
2018-02-20
How to Cite
1.
Adrovic A, Dedeoglu R, Sahin S, Barut K, Koka A, Cengiz D, Oztunc F, Kasapcopur O. Evaluation of pulmonary artery pressure in patients with juvenile systemic lupus erythematosus (jSLE). Bosn J of Basic Med Sci [Internet]. 2018Feb.20 [cited 2019Mar.25];18(1):66-1. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/2178
Section
Translational and Clinical Research