The influence of chronic intake of saccharin on rat hepatic and pancreatic function and morphology: gender differences

  • Bojana M. Andrejić Department of Histology and Embryology, Faculty of Medicine, University of Novi Sa
  • Vesna M. Mijatović Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad
  • Isidora N. Samojlik Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad
  • Olga J. Horvat Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad
  • Jelena D. Ćalasan Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad
  • Matilda A. Đolai Department of Histology and Embryology, Faculty of Medicine, University of Novi Sa
Keywords: saccharin, pancrea, liver, glucose, transaminases, rats

Abstract

There are opposite hypotheses on the effect of saccharin. Our aim was reviewing the influence of chronically ingested saccharin on the function and histological structure of liver and pancreas and all this in light of gender differences.

The rats were divided into control group – (Group C) and saccharin-treated group – (Group S) which was given a normal diet and 0.0005% saccharin in drinking water for 6 weeks. Liver and pancreas were histologically processed and quantitative histological analysis was performed. Glucose blood levels and plasma activities of aspartate transaminase (AST) and alanine transaminase (ALT), body weight, and food intake were analyzed.

Quantitative histological analysis determined that the values of diameter and volume density of both Langerhans islets and exocrine acini were significantly higher in S group, especially in males. AST levels were significantly higher in treated group. Glucose levels were higher in treated group, mainly due to the values of the female subgroup. Food intake was significantly higher in control group, while weight gain was higher in treated group. Treated males had significantly higher food intake and weight gain in comparison with treated females.

The data presented here suggests that chronic saccharin intake affects the examined parameters. Reported facts reflect various metabolic, hormonal and neural responses in males and females.

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The influence of chronic intake of saccharin on rat hepatic and pancreatic function and morphology: gender differences
Published
2013-05-20
How to Cite
1.
M. Andrejić B, M. Mijatović V, N. Samojlik I, J. Horvat O, D. Ćalasan J, A. Đolai M. The influence of chronic intake of saccharin on rat hepatic and pancreatic function and morphology: gender differences. Bosn J of Basic Med Sci [Internet]. 2013May20 [cited 2020Sep.30];13(2):94-9. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/2372
Section
Biochemistry