The effects of hypoglycemic and alcoholic coma on the blood-brain barrier permeability

  • Hatice Yorulmaz Department of Physiotherapy and Rehabilitation, Halic University
  • Fatma Burcu Seker Department of Physiology, Yeditepe University, Faculty of Medicine
  • Baria Oztas Department of Physiology, Istanbul University, Istanbul Faculty of Medicine
Keywords: blood-brain barrier, hypoglycemic coma, alcoholic coma

Abstract

In this investigation, the effects of hypoglycemic coma and alcoholic coma on the blood-brain barrier (BBB) permeability have been compared. Female adult Wistar albino rats weighing 180-230 g were divided into three groups: Control group (n=8), Alcoholic Coma Group (n=18), and Hypoglycemic Coma group (n=12). The animals went into coma approximately 3-4 hours after insulin administration and 3-5 minutes after alcohol administration. Evans blue (4mL/kg) was injected intravenously as BBB tracer. It was observed that the alcoholic coma did not significantly increase the BBB permeability in any of the brain regions when compared to control group. Changes in BBB permeability were significantly increased by the hypoglycemic coma in comparison to the control group values (p<0.01). Our findings suggest that hypoglycemic and alcoholic coma have different effects on the BBB permeability depending on the energy metabolism.

Downloads

Download data is not yet available.
The effects of hypoglycemic and alcoholic coma on the blood-brain barrier permeability
Published
2011-05-20
How to Cite
1.
Yorulmaz H, Burcu SekerF, Oztas B. The effects of hypoglycemic and alcoholic coma on the blood-brain barrier permeability. Bosn J of Basic Med Sci [Internet]. 2011May20 [cited 2020Nov.28];11(2):108-12. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/2591
Section
Biochemistry