Plasma nitric oxide and left ventricular function in rabbits after cardiac lymphatic obstruction

  • Ying-Li Wang Liaocheng People’s Hospital and Liaocheng Clinical School of Taishan Medical University, Department of Cardiology
  • Xiao-Hua Wang Liaocheng People’s Hospital and Liaocheng Clinical School of Taishan Medical University, Department of Cardiology
  • Ye Jin Liaocheng People’s Hospital and Liaocheng Clinical School of Taishan Medical University, Department of Cardiology
  • De-Gui Kong Liaocheng People’s Hospital and Liaocheng Clinical School of Taishan Medical University, Department of Cardiology
  • Le-Xin Wang Charles Sturt University, School of Biomedical Sciences
Keywords: cardiac lymphatic vessels, endothelium, nitric oxide, left ventricular function, rabbits

Abstract

This study was designed to investigate the effect of cardiac lymphatic obstruction on plasma nitric oxide (NO) and left ventricular function. The plasma NO was measured in study group (n=21) and control group rabbits (n=12) before, and 3, 7, 14, 30 and 90 days after the obstruction of cardiac lymphatic vessels. Left ventricular ejection fraction was measured with echocardiography. There was a significant reduction in the left ventricular ejection fraction following the lymphatic obstruction (0.72±0.02 vs. 0.61±0.02, p<0.01). Plasma NO in the control group remained unchanged during the observation period (54.2±4.4 vs. 52.0±4.2 μmol/L, p>0.05). In the study group, there was a small but significant increase in the plasma NO on day 3, 7 and 14 following the lymphatic obstruction (52.3±4.1 vs. 73.4±5.9 μmol/L, p<0.01). The plasma NO returned to the baseline levels on day 30 but reduced to 44.9±3.6 pmol/L on 90 days after the lymphatic obstruction (p<0.05). In conclusion, cardiac lymphatic obstruction was associated with a significant reduction in left ventricular function. It was also associated with an increase in the plasma NO in the first 2 weeks but there was a significant reduction in the NO levels three months after the lymphatic obstruction.

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Plasma nitric oxide and left ventricular function in rabbits after cardiac lymphatic obstruction
Published
2011-02-20
How to Cite
1.
Wang Y-L, Wang X-H, Jin Y, Kong D-G, Wang L-X. Plasma nitric oxide and left ventricular function in rabbits after cardiac lymphatic obstruction. Bosn J of Basic Med Sci [Internet]. 2011Feb.20 [cited 2020Oct.1];11(1):17-9. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/2617
Section
Biochemistry