Red Blood Cell Storage Lesion

Authors

  • Daryl J. Kor Mayo Clinic, Rochester, MN
  • Camille M Van Buskirk Mayo Clinic, Rochester, MN
  • Ognjen Gajic Mayo Clinic, Rochester, MN

DOI:

https://doi.org/10.17305/bjbms.2009.2750

Keywords:

red blood cell transfusion, storage lesion, transfusion effiacacy, transfusion risks

Abstract

The past two decades have witnessed increased scrutiny regarding efficacy and risk of the once unquestioned therapy of red blood cell (RBC) transfusion. Simultaneously, a variety of changes have been identified within the RBC and storage media during RBC preservation that are correlated with reduced tissue oxygenation and transfusion-associated adverse effects. These alterations are collectively termed the storage lesion and include extensive biochemical, biomechanical, and immunologic changes involving cells of diverse origin. Time-dependent falls is 2,3-diphosphoglycerate, intracellular RBC adenosine triphosphate, and nitric oxide have been shown to impact RBC deformability and delivery of oxygen to the end-organ. The accumulation of biologic response modifiers such as soluble CD40 ligand (sCD40L), lysophosphatidylcholine (lyso-PC), and Regulated on Activation, Normal T-cell Expressed and Secreted (RANTES) have been associated with altered recipient immune function as well. This review will address the alterations occurring within the RBC and storage media during RBC preservation and will address the potential clinical consequence thereof.

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Red Blood Cell Storage Lesion

Published

20-10-2009

Issue

Section

Review

Categories

How to Cite

1.
Red Blood Cell Storage Lesion. Biomol Biomed [Internet]. 2009 Oct. 20 [cited 2024 Dec. 4];9(1):S21-S27. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/2750