Acute Respiratory Distress Syndrome: Insights Gained from Clinical and Translational Research

  • Marija Kojicic Institute for Pulmonary Diseases of Vojvodina
  • Emir Festic Mayo Clinic
  • Ognjen Gajic Mayo Clinic Rochester
Keywords: Respiratory distress syndrome, adult, mechanical ventilation, pulmonary edema

Abstract

Acute lung injury and its more severe form acute respiratory distress syndrome (ARDS) are characterized by diffuse impairment of alveolocapillary membrane in the settings of different predisposing conditions such as sepsis, trauma and shock. Many intrahospital exposures, including aspiration, delayed resuscitation, high tidal volume mechanical ventilation and non critical use of transfusions may contribute or worsen ARDS. Therapy is targeted to treatment of predisposing condition, life supportive measures and prevention of nosocomial complications. Rigorous adherence to lung-protective mechanical ventilation is critical to prevent ventilator induced lung injury and decrease mortality. Although survival of ARDS patients has improved in the last decades ARDS mortality rates are still high and survivors encounter significant physical and psychological impairments

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Published
2009-10-20
How to Cite
1.
Kojicic M, Festic E, Gajic O. Acute Respiratory Distress Syndrome: Insights Gained from Clinical and Translational Research. Bosn J of Basic Med Sci [Internet]. 2009Oct.20 [cited 2019Jun.17];9(1):S59-S68. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/2764
Section
Reviews