Amino-Terminal Pro-Brain Natriuretic Peptid in Prediction of Left Ventricular Ejection Fraction

  • Mugdim Bajrić Internal Clinic, University Clinical Center
  • Fahir Baraković Internal Clinic, University Clinical Center
  • Zumreta Kušljugić Internal Clinic, University Clinical Center
  • Nermin Salkić Internal Clinic, University Clinical Center
  • Elmir Jahić Internal Clinic, University Clinical Center
  • Mensura Aščerić Department of Pharmacology and Toxicology, Faculty of Medicine, University of Tuzla
  • Farid Ljuca Department of Pharmacology and Toxicology, Faculty of Medicine, University of Tuzla
  • Denis Mršić Internal Clinic, University Clinical Center
  • Elnur Smajić Internal Clinic, University Clinical Center
  • Jasmin Čaluk Cardiovascular Clinic, University Clinical Center
  • Ramiz Hajrić Cardiovascular Clinic, University Clinical Center
Keywords: natriuretic peptides, heart failure, LVEF, prediction

Abstract

We aimed to evaluate levels of amino-terminal pro-brain natriuretic peptid (NT-proBNP) in prediction of left ventricular ejection fraction (LVEF) in heart failure patients. Prospective study on 60 consecutive patients with symptoms and signs of heart failure was performed. Blood samples for NT-proBNP analysis was taken from all test subjects and echocardiography was also done in all of them. According to LVEF value, patients were divided into four groups; those with <30%, 31 to 39%, 40 to 49% and >50%. NT-proBNP values correlated with LVEF value. Regression analyis was used to evaluate how well NT-proBNP values predict LVEF. We used Receiver Operating Characteristic Curve calculation to evaluate diagnostic performance of NT-proBNP in estimation of LVEF. Average value of NT-proBNP in test group was 3191,69±642,89 pg/ml (p<0,001). Average value of NT-proBNP decreased with higher LVEF categories with significant (p<0,001) and high negative correlation (r = -0,75). Stepwise multivariate linear regression analysis showed that logarithmic value of NT-proBNP was excellent predictor of LVEF value (p<0,05). Model equation based on regression analysis was LVEF=88,645-15,311 x log (NT-proBNP). Predictive model for LVEF yielded from regression analysis had sensitivities of 98% and 81%, specificities of 20% and 90%, positive predictive values of 86% and 78% and negative predictive values of 67% and 92% for predicting patients with LVEF<50% and LVEF<40%, respectively. There was negative linear correlation between NT-proBNP and LVEF. NT-proBNP was excellent predictor of LVEF value (p<0,05).

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Published
2008-08-20
How to Cite
1.
Bajrić M, Baraković F, Kušljugić Z, Salkić N, Jahić E, Aščerić M, Ljuca F, Mršić D, Smajić E, Čaluk J, Hajrić R. Amino-Terminal Pro-Brain Natriuretic Peptid in Prediction of Left Ventricular Ejection Fraction. BJBMS [Internet]. 20Aug.2008 [cited 22Mar.2019];8(3):282-6. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/2934
Section
Translational and Clinical Research