Correlation of Autoantibodies Presence Detected By IFA-anti-dsDNA, IFA-AMA and Immunoblotting with Corresponding Data in Clinical Management of Autoimmune Diseases

  • Đemo Subašić Institute of Clinical Immunology - University of Sarajevo Clinics Centre
  • Jasenko Karamehić Institute of Clinical Immunology - University of Sarajevo Clinics Centre
  • Farid Ljuca Department of Physiology, Faculty of Medicine, University of Tuzla
  • Faris Gavrankapetanović Institute of Clinical Immunology - University of Sarajevo Clinics Centre
  • Marina Delić-Šarac Institute of Clinical Immunology - University of Sarajevo Clinics Centre
  • Izet Eminović Faculty of Science, University of Tuzla
  • Dragan Kovačević Institute of Clinical Immunology - University of Sarajevo Clinics Centre
Keywords: SLE, AIH, PBC, IFA, AMA, anti-dsDNA, M-2, LKM-1, LC-1, SLA/LP

Abstract

Diagnosis and management of patients with SLE (Systemic Lupus Eritematosus), autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), involves specific diagnostic tests, such as IFA-AMA, IFA anti-dsDNA and immunoblotting for the detection of autoantibodies for specific autoantigens (mitochondria, dsDNA, M2, LKM-1, LC-1, SLA/LP). We established specific correlation between the detected autoantibodies and corresponding clinical findings.

The total of 813 serum specimens were probed with IFA-anti-dsDNA, 98 of which tested positive. We also performed dilution analysis to the end point for all the positive specimens. Numerous specimens were tested by IFA, AMA and immunoblotting.

Downloads

Download data is not yet available.
Correlation of Autoantibodies Presence Detected By IFA-anti-dsDNA, IFA-AMA and Immunoblotting with Corresponding Data in Clinical Management of Autoimmune Diseases
Published
2008-02-20
How to Cite
1.
Subašić Đemo, Karamehić J, Ljuca F, Gavrankapetanović F, Delić-Šarac M, Eminović I, Kovačević D. Correlation of Autoantibodies Presence Detected By IFA-anti-dsDNA, IFA-AMA and Immunoblotting with Corresponding Data in Clinical Management of Autoimmune Diseases. Bosn J of Basic Med Sci [Internet]. 2008Feb.20 [cited 2020Oct.22];8(1):86-2. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/3004
Section
Immunology