Morphologic Findings of the Ischemic Myocardium

  • Aida Hasanović Department of Anatomy, Faculty of Medicine, University of Sarajevo
  • Zakira Mornjaković Department of Hystology and Embriology, Faculty of Medicine, University of Sarajevo
  • Branko Faruk Dilberović Department of Clinical Pathology, Medical University of Vienna
  • Faruk Dilberović Department of Anatomy, Faculty of Medicine, University of Sarajevo
Keywords: anemia, diabetes mellitus, heart failure, kidney failure

Abstract

This study assesses the relation between qualitative and quantitative findings of myocytes and interstitial connective tissue in the ischemic heart disease. Qualitative and quantitative changes of myocytes and interstitial connective tissue were studied on the serial cross myocardial sections from 20 autopsied hearts with ischemic lesions, stained by immunohistochemistry using a monoclonal antibody (von Willebrand factor) and with hematoxylin-eosin method. Myocardial sections included proximal and distal part of occlusion and area of occlusion of coronary vessels. The volume densities (V V) of the cardiac myocytes and interstitial fibrosis in the group with coronary occlusion were examined stereologically and compared with control group. The findings showed a significant reduction in the volume density of myocytes and an increase in the volume density of interstitial fibrosis in patients with coronary occlusion compared with control group. Significant reduction in the volume density of myocytes and an increase in volume density of interstitial fibrosis were greater in the distal part of occlusion and area of occlusion, than in the proximal part of the occlusion. Our stereological results give useful quantitative information's of changes in myocardium parts during coronary occlusion as well as in normal conditions, and represent objective proof of significant changes in ischemic myocardium described by qualitative analyses.

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Published
2006-02-20
How to Cite
1.
Hasanović A, Mornjaković Z, Faruk Dilberović B, Dilberović F. Morphologic Findings of the Ischemic Myocardium. Bosn J of Basic Med Sci [Internet]. 2006Feb.20 [cited 2019Apr.19];6(1):82-5. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/3218
Section
Anatomy