Significantly Reduced Salivary Nitric Oxide Synthesis in Patients with Parkinson’s Disease

  • Jasminko Huskić Institute of Physiology and Biochemistry, School ofMedicine, University of Sarajevo
  • Alma Paperniku Institute of Pharmacology, School of Medicine, University of Sarajevo
  • Azra Husić Clinic for Gastroenterohepatology, University of Sarajevo Clinics Center
  • Faruk Alendar Dermatovenerology Clinic, University of Sarajevo Clinics Center
  • Nedžad Mulabegović Clinic for Gastroenterohepatology, University of Sarajevo Clinics Center
Keywords: nitric oxide, Parkinson’s disease, saliva

Abstract

In order to study concentration of nitric oxide (NO) in the saliva of patients with Parkinson’s disease (PD), we measured the concentration of its stable metabolite nitrite (NO2-) in the saliva of these patients and healthy subjects. We analyzed saliva flow rate and salivary NO concentrations in 16 subjects with Parkinson’s disease and in 16 healthy subjects. Concentration of nitrite was determined by colorimetric method using Griess reaction. Saliva flow rate was significantly lower in patients with Parkinson’s disease (0,2±0,03 mL/min; X±SEM) than in healthy subjects. Salivary NO2-concen-tration was significantly lower (5,0210,64) than in healthy individuals (22,3911,24; p<0,0001).

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Significantly Reduced Salivary Nitric Oxide Synthesis in Patients with Parkinson’s Disease
Published
2005-08-20
How to Cite
1.
Huskić J, Paperniku A, Husić A, Alendar F, Mulabegović N. Significantly Reduced Salivary Nitric Oxide Synthesis in Patients with Parkinson’s Disease. Bosn J of Basic Med Sci [Internet]. 2005Aug.20 [cited 2021Oct.28];5(3):86-9. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/3277
Section
Translational and Clinical Research