Significantly Reduced Salivary Nitric Oxide Synthesis in Patients with Parkinson’s Disease

Jasminko Huskić; Alma Paperniku; Azra Husić; Faruk Alendar; Nedžad Mulabegović

doi:10.17305/bjbms.2005.3277

Authors

Jasminko Huskić Institute of Physiology and Biochemistry, School ofMedicine, University of Sarajevo
Alma Paperniku Institute of Pharmacology, School of Medicine, University of Sarajevo
Azra Husić Clinic for Gastroenterohepatology, University of Sarajevo Clinics Center
Faruk Alendar Dermatovenerology Clinic, University of Sarajevo Clinics Center
Nedžad Mulabegović Clinic for Gastroenterohepatology, University of Sarajevo Clinics Center

DOI:

https://doi.org/10.17305/bjbms.2005.3277

Keywords:

nitric oxide, Parkinson’s disease, saliva

Abstract

In order to study concentration of nitric oxide (NO) in the saliva of patients with Parkinson’s disease (PD), we measured the concentration of its stable metabolite nitrite (NO2-) in the saliva of these patients and healthy subjects. We analyzed saliva flow rate and salivary NO concentrations in 16 subjects with Parkinson’s disease and in 16 healthy subjects. Concentration of nitrite was determined by colorimetric method using Griess reaction. Saliva flow rate was significantly lower in patients with Parkinson’s disease (0,2±0,03 mL/min; X±SEM) than in healthy subjects. Salivary NO2-concen-tration was significantly lower (5,0210,64) than in healthy individuals (22,3911,24; p<0,0001).