Correlation of the HER-2 protein expression and other clinicopathological features of ductal infiltrative breast cancer

  • Svjetlana Radović Institute of Pathology, Sarajevo University School of Medicine
  • Mirsad Babić Institute of Pathology, Sarajevo University School of Medicine
  • Mirsad Dorić Institute of Pathology, Sarajevo University School of Medicine
  • Edina Balta Clinic for Glandular Surgery, University Clinical Center Sarajevo
  • Erol Kapetanović Clinic for Glandular Surgery, University Clinical Center Sarajevo
  • Senad Šečić Clinic for Glandular Surgery, University Clinical Center Sarajevo
Keywords: HER-2, immunohistochemistry breast cancer

Abstract

The aim of the study was to investigate the relationship between the expression of the HER-2 membrane protein and other clinical-pathological parameters such as: histological size of the tumor, degree of the tumor's differentiation, presence of vascular invasion and presence of metastases in regional lymph nodes, in cases of ductal infiltrative breast cancer. We have investigated 56 cases of ductalinfiltrative breast cancer. In all patients a mastectomy with a dissection of axillary lymph nodes has been performed. All tissue samples, taken by biopsy, were embedded in the paraffin, stained by hematoxylin-eosin technique and screened, and evaluation was performed by using a semiquantitative method of the immunohistochemical expression of the HER-2 protein. A decrease of the protein HER-2 expression was noticed in cases of an increase of the tumor's diameter above 50 mm. Increased expression of the HER-2 protein was noticed in cases of moderate (grade II) and poor (grade III) differentiation of carcinoma, as well as in cases where there was no metastases in the regional lymph nodes. No relationship has been observed between the expression of HER-2 and occurrence of vascular invasion. In cases of ductalinfiltrative breast cancer the expression of HER-2 protein is in correlation with the size and degree of tumor's differentiation, as well as with the presence of metastases in regional lymph nodes.

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Author Biography

Senad Šečić, Clinic for Glandular Surgery, University Clinical Center Sarajevo
 
Correlation of the HER-2 protein expression and other clinicopathological features of ductal infiltrative breast cancer
Published
2005-02-20
How to Cite
1.
Radović S, Babić M, Dorić M, Balta E, Kapetanović E, Šečić S. Correlation of the HER-2 protein expression and other clinicopathological features of ductal infiltrative breast cancer. Bosn J of Basic Med Sci [Internet]. 2005Feb.20 [cited 2020Oct.1];5(1):3-. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/3327
Section
Pathology