DOI: http://dx.doi.org/10.17305/bjbms.2018.3539 | Full Text: [PDF]

Recent advances in research on aspartate β-hydroxylase (ASPH) in pancreatic cancer: A brief update

Guofang Hou, Boran Xu, Yanghui Bi, Chuanlin Wu, Beibei Ru, Bei Sun, Xuewei Bai

Abstract


Pancreatic cancer (PC) is a highly aggressive tumor, often difficult to diagnose and treat. Aspartate β-hydroxylase (ASPH) is a type II transmembrane protein and the member of α-ketoglutarate-dependent dioxygenase family, found to be overexpressed in different cancer types, including PC. ASPH appears to be involved in the regulation of proliferation, invasion and metastasis of PC cells through multiple signaling pathways, suggesting its role as a tumor biomarker and therapeutic target. In this review, we briefly summarize the possible mechanisms of action of ASPH in PC and recent progress in the therapeutic approaches targeting ASPH.



Keywords


Aspartate β-hydroxylase; pancreatic cancer; Notch signaling pathway; Mitochondrial DNA; NK cell

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References


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