How latent viruses cause breast cancer: An explanation based on the microcompetition model

Authors

  • Hanan Polansky The Center for the Biology of Chronic Disease (CBCD), New York, NY, USA
  • Hava Schwab The Center for the Biology of Chronic Disease (CBCD), New York, NY, USA

DOI:

https://doi.org/10.17305/bjbms.2018.3950

Keywords:

Breast cancer, microcompetition, GABP, p300/CBP, HPV, EBV, latent viruses, BRCA1, BRCA1 mutation

Abstract

Most breast cancer cases show a decrease in the concentration of the breast cancer type 1 susceptibility protein (BRCA1). However, only a small portion of these cases have a mutated BRCA1 gene. Although many attempts have been made to identify the reason for the decrease in BRCA1 concentration in sporadic, non-heritable breast cancer cases, the cause is still unknown. In this review, we use the Microcompetition Model to explain how certain latent viruses, which are frequently detected in breast cancer tumors, can decrease the expression of the BRCA1 gene and cause the development of breast tumors.

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How latent viruses cause breast cancer: An explanation based on the microcompetition model

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Published

20-08-2019

Issue

Vol. 19 No. 3 (2019)

Section

Review

Categories

How to Cite

1.
How latent viruses cause breast cancer: An explanation based on the microcompetition model. Biomol Biomed [Internet]. 2019 Aug. 20 [cited 2025 May 2];19(3):221-6. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/3950
Received 2018-10-25
Accepted 2018-12-11
Published 2019-08-20