Adjunct corticosteroid treatment in patients with pneumonia: A precision medicine approach

  • Srdjan Gavrilovic Intensive Care Unit, Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia https://orcid.org/0000-0002-7752-3833
  • Ana Andrijevic Intensive Care Unit, Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia
  • Aida Mujakovic Department of Internal Medicine, General Hospital “Prim. Dr. Abdulah Nakaš”, Sarajevo, Bosnia and Herzegovina Sarajevo Medical School, Sarajevo School of Science and Technology, Sarajevo, Bosnia and Herzegovina https://orcid.org/0000-0002-0022-1482
  • Yewande Odeyemi Department of Pulmonary Medicine, Mayo Clinic, Rochester, Minnesota, USA https://orcid.org/0000-0002-4446-198X
  • Belma Paralija Clinic for Pulmonary Diseases, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina https://orcid.org/0000-0001-7556-671X
  • Ognjen Gajic Department of Pulmonary Medicine, Mayo Clinic, Rochester, Minnesota, USA https://orcid.org/0000-0003-4218-0890
Keywords: Pneumonia, corticosteroids, C-reactive protein, biomarkers, intensive care unit, ICU

Abstract

Pneumonia is the leading infectious cause of death worldwide. While inflammation is critically important in host response to microbial invasion, exaggerated inflammation can damage the lungs, contributing to respiratory failure and mortality. Corticosteroids are effective in reducing inflammation and can also cause immune suppression. Presently, clinicians are unable to reliably distinguish between exaggerated and appropriate immune response and thus cannot rapidly identify patients most likely to benefit from adjunctive corticosteroids. In this review, we propose a biomarker-guided, precision medicine approach to corticosteroid treatment, aimed to give these medications at appropriate dose and time and only to patients who have exaggerated inflammation.

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Author Biographies

Aida Mujakovic, Department of Internal Medicine, General Hospital “Prim. Dr. Abdulah Nakaš”, Sarajevo, Bosnia and Herzegovina Sarajevo Medical School, Sarajevo School of Science and Technology, Sarajevo, Bosnia and Herzegovina
Department of Internal Medicine
Yewande Odeyemi, Department of Pulmonary Medicine, Mayo Clinic, Rochester, Minnesota, USA
Department of Pulmonary Medicine
Ognjen Gajic, Department of Pulmonary Medicine, Mayo Clinic, Rochester, Minnesota, USA
Department of Pulmonary Medicine
Adjunct corticosteroid treatment in patients with pneumonia: A precision medicine approach
Published
2019-11-08
How to Cite
1.
Gavrilovic S, Andrijevic A, Mujakovic A, Odeyemi Y, Paralija B, Gajic O. Adjunct corticosteroid treatment in patients with pneumonia: A precision medicine approach. Bosn J of Basic Med Sci [Internet]. 2019Nov.8 [cited 2019Nov.18];19(4):315-20. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/3977
Section
Reviews