Association of serum chemerin and inflammatory factors with type 2 diabetes macroangiopathy and waist-to-stature ratio

  • Mengxue Yang Department of Endocrinology, The Fifth People’s Hospital of Shanghai, Fudan University, Shanghai, China; Department of Endocrinology, Zunyi Medical University, Zunyi, China https://orcid.org/0000-0003-4189-4226
  • Xue Zhou Department of Endocrinology, Zunyi Medical University, Zunyi, China https://orcid.org/0000-0002-3810-0803
  • Jie Xu School of Public Health, Zunyi Medical University, Zunyi, China
  • Bo Yang Department of Endocrinology, Zunyi Medical University, Zunyi, China
  • Jie Yu School of Public Health, Zunyi Medical University, Zunyi, China
  • Qihai Gong Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, China
  • Xuan Zhang Department of Endocrinology, Zunyi Medical University, Zunyi, China
  • Xiaohua Sun Department of Endocrinology, Ningbo No. 2 Hospital, Ningbo, China
  • Qun Zhang Department of Endocrinology, Ningbo No. 2 Hospital, Ningbo, China
  • Jinying Xia Department of Endocrinology, Ningbo No. 2 Hospital, Ningbo, China
  • Jianhui Li Department of Endocrinology, Ningbo No. 2 Hospital, Ningbo, China
Keywords: Type 2 diabetes, T2DM, macroangiopathy, chemerin, inflammatory factor, glycolipid metabolism

Abstract

Chemerin is an adipocytokine that participates in glycolipid metabolism; however, its association with type 2 diabetes (T2DM) with lower extremity macroangiopathy (T2DM-V) has rarely been reported. This study explored the association of chemerin and inflammatory factors with body fat parameters, glucolipid metabolism, and insulin resistance (IR) in T2DM and T2DM-V. Patients were classified into normal glucose regulation (NGR), T2DM, and T2DM-V groups. Serum chemerin, glucolipid metabolic parameters, transforming growth factor (TGF)-β, interleukin (IL)-6, monocyte chemoattractant protein (MCP)-1 and fasting insulin levels were measured along with HOMA-IR, body mass index (BMI), and waist-to-stature ratio (WSR). Serum chemerin, TGF-β, IL-6 and MCP-1 levels were significantly higher in T2DM groups than in NGR group, and BMI, WSR, fasting plasma glucose (FPG), 2hPG, glycated hemoglobin (HbA1c), triglycerides (TG) and HOMA-IR were higher in T2DM-V subgroups with moderate or severe lower extremity macroangiopathy than in NGR group, simple T2DM group, and T2DM-V subgroup with mild macroangiopathy. FPG, 2hPG, HbA1c, TG and HOMA-IR were higher in T2DM-V subgroup with severe macroangiopathy than in T2DM-V with moderate macroangiopathy (p < 0.05). In all groups, serum chemerin levels were positively correlated with BMI, WSR, FPG, 2hPG, HbA1c, fasting insulin, aspartate transaminase, TG, TGF-β, IL-6 and HOMA-IR (p < 0.05) and negatively correlated with high-density lipoprotein cholesterol [HDL-c] (p < 0.05). Multiple stepwise regression analysis showed that 2hPG, HbA1c, and HDL-c were independent predictors of serum chemerin levels (β = -0.768, -0.122, -0.115, and 3.261, respectively; p < 0.01). Collectively, chemerin, factors associated with obesity, pathological and physiological changes in glucolipid metabolism, and inflammatory factors may promote the development of T2DM macroangiopathy.

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Association of serum chemerin and inflammatory factors with type 2 diabetes macroangiopathy and waist-to-stature ratio
Published
2019-04-29
How to Cite
1.
Yang M, Zhou X, Xu J, Yang B, Yu J, Gong Q, Zhang X, Sun X, Zhang Q, Xia J, Li J. Association of serum chemerin and inflammatory factors with type 2 diabetes macroangiopathy and waist-to-stature ratio. Bosn J of Basic Med Sci [Internet]. 2019Apr.29 [cited 2019May22];00. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/4002
Section
Pathology