Can telomere length predict bone health? A review of current evidence

  • Sok Kuan Wong Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia https://orcid.org/0000-0003-1184-4551
  • Soelaiman Ima-Nirwana Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia
  • Kok-Yong Chin Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia; State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China https://orcid.org/0000-0001-6628-1552
Keywords: Bone health, osteoblast, osteoclast, osteoporosis, telomerase, telomere

Abstract

Telomeres are repetitive DNA sequences located at the end of chromosomes that serve as a protective barrier against chromosomal deterioration during cell division. Approximately 50–200 base pairs of nucleotides are lost per cell division, and new repetitive nucleotides are added by the enzyme telomerase, allowing telomere maintenance. Telomere shortening has been proposed as an indicator for biological aging, but its relationship with age-related osteoporosis is ambiguous. We summarize the current evidence on the relationship between telomere length and bone health in experimental and epidemiological studies, which serve as a scientific reference for the development of novel diagnostic markers of osteoporosis or novel therapeutics targeting telomere and telomerase of bone cells to treat osteoporosis.

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Can telomere length predict bone health? A review of current evidence
Published
2020-03-10
How to Cite
1.
Wong SK, Ima-Nirwana S, Chin K-Y. Can telomere length predict bone health? A review of current evidence. Bosn J of Basic Med Sci [Internet]. 2020Mar.10 [cited 2020Jul.14];. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/4664
Section
Reviews

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