An insight into osteoarthritis susceptibility: Integration of immunological and genetic background

Debora Stefik; Vladimir Vranic; Nemanja Ivkovic; Dzihan Abazovic; Dusan  Maric; Danilo Vojvodic; Gordana  Supic

doi:10.17305/bjbms.2020.4735

Authors

Debora Stefik Institute for Medical Research, Military Medical Academy, Belgrade, Serbia https://orcid.org/0000-0001-6610-4812
Vladimir Vranic Clinic for Orthopedic Surgery and Traumatology, Military Medical Academy, Belgrade, Serbia https://orcid.org/0000-0003-4625-0155
Nemanja Ivkovic Institute for Medical Research, Military Medical Academy, Belgrade, Serbia https://orcid.org/0000-0001-8982-8848
Dzihan Abazovic Renova Clinic, Belgrade, Serbia https://orcid.org/0000-0002-7676-458X
Dusan Maric Institute for Child and Youth Health Care of Vojvodina, Novi Sad, Serbia https://orcid.org/0000-0002-3981-3215
Danilo Vojvodic Institute for Medical Research, Military Medical Academy, Belgrade, Serbia; Medical Faculty of Military Medical Academy, University of Defense, Belgrade, Serbia https://orcid.org/0000-0001-9308-3076
Gordana Supic Institute for Medical Research, Military Medical Academy, Belgrade, Serbia; Medical Faculty of Military Medical Academy, University of Defense, Belgrade, Serbia https://orcid.org/0000-0003-0350-4733

DOI:

https://doi.org/10.17305/bjbms.2020.4735

Keywords:

osteoarthritis, immunology, genetic polymorphisms, genetic susceptibility

Abstract

Osteoarthritis (OA) is a progressive degenerative disease that affects all synovial joints, causing the disability of the main locomotor diarthrodial joints. OA pathogenesis is caused by a complex interplay between a number of genetic and environmental risk factors, involved in the early onset and progression of this chronic inflammatory joint disease. Uncovering the underlying immunological and genetic mechanisms will enable an insight into OA pathophysiology and lead to novel and integrative approaches in the treatment of OA patients, together with a reduction of the disease risk, or a delay of its onset in susceptible patients.