Cardiotrophin-1: A new predictor of atrial fibrillation relapses after successful cardioversion


  • Ibrahim Altun Mugla Sitki Kocman University, Faculty of Medicine, Department of Cardiology
  • Burak Pamukcu Istanbul University, Istanbul Medical Faculty, Department of Cardiology
  • Cenk Eray Yildiz Istanbul University, Institute of Cardiology, Department of Cardiovascular Surgery
  • Selda Can Arkaya Istanbul University, Istanbul Medical Faculty, Department of Biochemistry
  • Goksel Guz Istanbul University, Istanbul Medical Faculty, Department of Cardiology
  • Akar Yilmaz Istanbul University, Istanbul Medical Faculty, Department of Cardiology
  • Ahmet Kaya Bilge Istanbul University, Istanbul Medical Faculty, Department of Cardiology
  • Umit Mutlu Turkoglu Istanbul University, Istanbul Medical Faculty, Department of Biochemistry
  • Kamil Adalet Istanbul University, Istanbul Medical Faculty, Department of Cardiology



Atrial fibrillation, cardioversion, cardiotrophin-1


We aimed to investigate whether or not cardiotrophin-1 (CT-1) can be used as a predictor of sinus rhythm constancy in patients with atrial fibrillation (AF) converted to sinus rhythm. Thirty two patients with AF (48-78 years), without any structural heart disease were enrolled for the study. The control group consisted of 32, age and gender matched healthy persons. Measurements of CT-1 were made after transthoracic and transesophageal echocardiography prior to cardioversion (CV). Relapses of AF were investigated by monthly electrocardiograms (ECGs) and ambulatory ECGs at 1st, 3rd, and 6th month. At the end of 6th month, measurements of CT-1 were repeated. At the beginning patients with AF had increased CT-1 levels when compared to controls (0.94 ± 0.32 pg/mL vs. 0.30 ± 0.12 pg/mL, [p < 0.001]). At the end of follow-up of the 32 patients, 17 (53%) had AF relapse. Age, initial duration of AF, left ventricle diameters, ejection fraction, left atrium appendix flow rates were similar among patients with and without AF relapse. However, basal left atrium diameter (4.24 ± 0.14 cm vs. 4.04 ± 0.22 cm, p = 0.005), pulmonary artery pressure (32.82 ± 5 vs. 28.60 ± 6.23 mmHg, p = 0.004) and CT-1 values (1.08 ± 0.37 vs. 0.82 ± 0.16 pg/mL, p = 0.02) were significantly increased in patients with AF relapse. Furthermore, patients with relapsed AF had higher CT-1 levels at 6th month when compared to those in sinus rhythm (1.00 ± 0.40 vs. 0.71 ± 0.23 pg/mL). We conclude that post-CV, AF relapses are more frequent among patients with increased baseline CT-1 levels, and CT-1 may be a potential predictor of AF relapse.


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Cardiotrophin-1: A new predictor of atrial fibrillation relapses after successful cardioversion


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Cardiotrophin-1: A new predictor of atrial fibrillation relapses after successful cardioversion. Biomol Biomed [Internet]. 2015 Jul. 23 [cited 2024 Mar. 1];15(3):68-73. Available from: