Biomaterials and host versus graft response: a short review


  • Tomaz Velnar University Medical Centre Maribor, Department of Neurosurgery
  • Gorazd Bunc University Medical Centre Maribor, Department of Neurosurgery
  • Robert Klobucar Royal Berkshire Hospital, Reading, United Kingdom
  • Lidija Gradisnik Laboratory for Cell Cultures, Medical Faculty Maribor



host versus graft disease, biomaterial, wound healing, transplant, tissue


Biomaterials and biotechnology are increasing becoming an important area in modern medicine. The main aim in this area is the development of materials, which are biocompatible to normal tissue. Tissue-implant interactions with molecular, biological and cellular characteristics at the implant-tissue interface are important for the use and development of implants. Implantation may cause an inflammatory and immune response in tissue, foreign body reaction, systemic toxicity and imminent infection. Tissue-implant interactions determine the implant life-period. The aims of the study are to consider the biological response to implants. Biomaterials and host reactions to implants and their mechanisms are also briefly discussed.


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Rossomando EF. Prosthodontics and implants: From xenodontics to biodontics. Compend Contin Educ Dent 2007; 28(8):418-20.

Binyamin G, Shafi BM, Mery CM. Biomaterials: A primer for surgeons. Semin Pediatr Surg 2006; 15(4):276-83.

Latour RA Jr. Future materials for foot surgery. Clin Podiatr Med Surg 1995; 12(3):519-44.

Navarro M, Michiardi A, Castaño O, Planell JA. Biomaterials in orthopaedics. J R Soc Interface 2008; 5(27):1137-58.

Zim S. Skeletal volume enhancement: Implants and osteotomies. Curr Opin Otolaryngol Head Neck Surg 2004; 12(4):349-56.

Sepulveda P, Jones JR, Hench LL. Bioactive sol-gel foams for tissue repair. J Biomed Mater Res 2002; 59(2):340-8.

Courtney JM, Irvine L, Jones C, Mosa SM, Robertson LM, Srivastava S. Biomaterials in medicine – A bioengineering perspective. Int J Artif Organs 1993; 16(3):164-71.

Warren SM, Sylvester K, Chen CM, Hedrick MH, Longaker MT. New directions in bioabsorbable technology. Orthopedics 2002; 25 10 Suppl: s1201-10.

Wilkinson CD. Making structures for cell engineering. Eur Cell Mater 2004; 22(8):21-6.

Ashammakhi N, Ndreu A, Yang Y, Ylikauppila H, Nikkola L, Hasirci V. Tissue engineering: A new take-off using nanofiber-based scaffolds. J Craniofac Surg 2007; 18(1):3-17.

Yang J, Yamato M, Kohno C, Nishimoto A, Sekine H, Fukai F, et al. Cell sheet engineering: Recreating tissues without biodegradable scaffolds. Biomaterials 2005; 26(33):6415-22.

Sigler M, Paul T, Grabitz RG. Biocompatibility screening in cardiovascular implants. Z Kardiol 2005; 94(6):383-91.

Greisler HP, Petsikas D, Lam TM, Patel N, Ellinger J, Cabusao E, et al. Kinetics of cell proliferation as a function of vascular graft material. J Biomed Mater Res 1993; 27(7):955-61.

Padera RF, Colton CK. Time course of membrane microarchitecture-driven neovascularization. Biomaterials 1996; 17(3):277-84.

Kirkpatrick CJ, Krump-Konvalinkova V, Unger RE, Bittinger F, Otto M, Peters K. Tissue response and biomaterial integration: The efficacy of in vitro methods. Biomol Eng 2002; 19(2-6):211-7.

Tiwari A, Salacinski H, Seifalian AM, Hamilton G. New prostheses for use in bypass grafts with special emphasis on polyurethanes. Cardiovasc Surg 2002; 10(3):191-7.

Greisler HP, Cabusao EB, Lam TM, Murchan PM, Ellinger J, Kim DU. Kinetics of collagen deposition within bioresorbable and nonresorbable vascular prostheses. ASAIO Trans 1991; 37(3):M472-5.

Greisler HP, Joyce KA, Kim DU, Pham SM, Berceli SA, Borovetz HS. Spatial and temporal changes in compliance following implantation of bioresorbable vascular grafts. J Biomed Mater Res 1992; 26(11):1449-61.

Shin H. Fabrication methods of an engineered microenvironment for analysis of cell-biomaterial interactions. Biomaterials 2007; 28(2):126-33.

Brauker JH, Carr-Brendel VE, Martinson LA, Crudele J, Johnston WD, Johnson RC. Neovascularization of synthetic membranes directed by membrane microarchitecture. J Biomed Mater Res 1995; 29(12):1517-24.

Anderson JM, Gristina AG, Hanson SR, Harker LA, Johnson RJ, Meritt K, et al. Host reactions to biomaterials and their evaluation. In: Rattner BD, Hoffman AS, editors. Biomaterials Science. San Diego: Academic Press; 1996. p. 165-214.

Greisler HP, Dennis JW, Endean ED, Ellinger J, Buttle KF, Kim DU. Derivation of neointima in vascular grafts. Circulation 1988; 78:I6-12.

Tardito E, Biondo B, Caputo V, Freddi G, Grosso E, Mantero S, et al. Biodegradation of dacron vascular prostheses. Physico-chemical, histological, morphometric and ultra-structural study. Minerva Cardioangiol 1993; 41(3):59-80.

Lindenauer SM, Stanley JC, Zelenock GB, Cronenwett JL, Whitehouse WM Jr, Erlandson EE. Aorto-iliac reconstruction with Dacron double velour. J Cardiovasc Surg (Torino) 1984; 25(1):36-42.

Esposito M, Grusovin MG, Worthington HV. Interventions for replacing missing teeth: Antibiotics at dental implant placement to prevent complications. Cochrane Database Syst Rev 2013; 7:CD004152.

Orenstein SB, Saberski ER, Klueh U, Kreutzer DL, Novitsky YW. Effects of mast cell modulation on early host response to implanted synthetic meshes. Hernia 2010; 14(5):511-6.

Anderson JM. Inflammatory response to implants. Asaio Trans 1988; 34(2):101-7.

Albrektsson T. Hard tissue implant interface. Aust Dent J 2008; 53(1):34-8.

Christensen L. Normal and pathologic tissue reactions to soft tissue gel fillers. Dermatol Surg 2007;33 Suppl 2:S168-75.,

Robson MC, Steed DL, Franz MG. Wound healing: Biologic features and approaches to maximize healing trajectories. Curr Probl Surg 2001; 38(2):72-140.

Labler L, Mica L, Härter L, Trentz O, Keel M. Influence of V.A.C.-therapy on cytokines and growth factors in traumatic wounds. Zentralbl Chir 2006; 131 Suppl 1:S62-7.

Broughton G 2nd, Janis JE, Attinger CE. The basic science of wound healing. Plast Reconstr Surg 2006; 117 Suppl 7:12S-34.

Lawrence WT. Physiology of the acute wound. Clin Plast Surg 1998; 25(3):321-40.

Richardson M. Acute wounds: An overview of the physiological healing process. Nurs Times 2004; 100:50-3.

Okan D, Woo K, Ayello EA, Sibbald G. The role of moisture balance in wound healing. Adv Skin Wound Care 2007; 20(1):39-53.,

Strecker-McGraw MK, Jones TR, Baer DG. Soft tissue wounds and principles of healing. Emerg Med Clin North Am 2007; 25(1):1-22.

Attinger CE, Janis JE, Steinberg J, Schwartz J, Al-Attar A, Couch K. Clinical approach to wounds: Débridement and wound bed preparation including the use of dressings and wound-healing adjuvants. Plast Reconstr Surg 2006; 117 7 Suppl:72S-109.

Broughton G, Janis JE, Attinger CE. Wound healing: An overview. Plast Reconstr Surg 2006; 117 Suppl 7:1-32.,

Rice J. Secondary intention wound healing – Pathphysiology and management. Collegian 2000; 7(3):40-1.

Vanwijck R. Surgical biology of wound healing. Bull Mem Acad R Med Belg 2001; 156(3-4):175-84.

Degreef HJ. How to heal a wound fast. Dermatol Clin 1998; 16(2):365-75.

Panuncialman J, Falanga V. The science of wound bed preparation. Surg Clin North Am 2009; 89(3):611-26.

Szycher M, Lee SJ. Modern wound dressings: A systematic approach to wound healing. J Biomater Appl 1992; 7(2):142-213.

Pool JG. Normal hemostatic mechanisms: A review. Am J Med Technol 1977; 43(8):776-80.

Whitney JD. Overview: Acute and chronic wounds. Nurs Clin North Am 2005; 40(2):191-205.

Natarajan S, Williamson D, Stiltz AJ, Harding K. Advances in wound care and healing technology. Am J Clin Dermatol 2000; 1(5):269-75.

Jespersen J. Pathophysiology and clinical aspects of fibrinolysis and inhibition of coagulation. Experimental and clinical studies with special reference to women on oral contraceptives and selected groups of thrombosis prone patients. Dan Med Bull 1988; 35(1):1-33.

Hart J. Inflammation 1: Its role in the healing of acute wounds. J Wound Care 2002; 11(6):205-9.

Steed DL. Wound-healing trajectories. Surg Clin North Am 2003; 83(3):547-55, vi-vii.

Flanga M. The physiology of wound healing. J Wound Care 2000; 9(6):299-300.

Edwards SL. Tissue viability: Understanding the mechanisms of injury and repair. Nurs Stand 2006; 21(13):48-56; quiz 58.

Diegelmann RF, Evans MC. Wound healing: An overview of acute, fibrotic and delayed healing. Front Biosci 2004; 9:283-9.

Hunt TK, Hopf H, Hussain Z. Physiology of wound healing. Adv Skin Wound Care 2000; 13 2 Suppl:6-11.

Glat PM, Longaker MT. Wound healing. In: Aston SJ, Beasley RW, Thorne CH, editors. Grabb and Smith’s Plastic Surgery. 5th ed. Philadelphia: Lippincott; 1997. p. 3-12.

Sieggreen MY. Healing of physical wounds. Nurs Clin North Am 1987; 22(2):439-47.

Ennis WJ, Meneses P. Wound healing at the local level: The stunned wound. Ostomy Wound Manage 2000; 46 1A Suppl:39S-48S; quiz 49S-50.

Hess CT. Skin care basics. Adv Skin Wound Care 2000; 13:127-8.

Witte MB, Barbul A. General principles of wound healing. Surg Clin North Am 1997; 77(3):509-28.

Ramasastry SS. Acute wounds. Clin Plast Surg 2005; 32(2):195-208.

Greenhalgh DG. The role of apoptosis in wound healing. Int J Biochem Cell Biol 1998; 30(9):1019-30.

Walmsley GG, Maan ZN, Wong VW, Duscher D, Hu MS, Zielins ER, et al. Scarless wound healing: Chasing the holy grail. Plast Reconstr Surg 2015; 135(3):907-17.

Yates CC, Hebda P, Wells A. Skin wound healing and scarring: Fetal wounds and regenerative restitution. Birth Defects Res C Embryo Today 2012; 96(4):325-33.

Baum CL, Arpey CJ. Normal cutaneous wound healing: Clinical correlation with cellular and molecular events. Dermatol Surg 2005; 31(6):674-86.

Servold SA. Growth factor impact on wound healing. Clin Podiatr Med Surg 1991; 8(4):937-53.

Moon JJ, Matsumoto M, Patel S, Lee L, Guan JL, Li S. Role of cell surface heparan sulfate proteoglycans in endothelial cell migration and mechanotransduction. J Cell Physiol 2005; 203(1):166-76.

Gouverneur M, Berg B, Nieuwdorp M, Stroes E, Vink H. Vasculoprotective properties of the endothelial glycocalyx: Effects of fluid shear stress. J Intern Med 2006; 259(4):393-400.

Clark RA. Regulation of fibroplasia in cutaneous wound repair. Am J Med Sci 1993; 306(1):42-8.

Mulder GD, Vande Berg JS. Cellular senescence and matrix metalloproteinase activity in chronic wounds. Relevance to debridement and new technologies. J Am Podiatr Med Assoc 2002; 92(1):34-7.

Falanga V. Wound healing and chronic wounds. J Cutan Med Surg 1998; 3 Suppl 1:S1-1-5.

Luttikhuizen DT, Harmsen MC, Van Luyn MJ. Cellular and molecular dynamics in the foreign body reaction. Tissue Eng 2006; 12(7):1955-70.

Anderson JM, Rodriguez A, Chang DT. Foreign body reaction to biomaterials. Semin Immunol 2008; 20(2):86-100.

Okada F. Beyond foreign-body-induced carcinogensis: Impact of reactive oxigen species derived from inflammatory cells in tumorigenic conversion and tumor progression. Int J Cancer 2007; 121(11):2364-72.

Lim HW. The complement system. Activation, modulation, and clinical relevance. Dermatol Clin 1990; 8(4):609-18.

Bohana-Kashtan O, Ziporen L, Donin N, Kraus S, Fishelson Z. Cell signals transduced by complement. Mol Immunol 2004; 41(6-7):583-97.

Podack ER, Tschopp J. Membrane attack by complement. Mol Immunol 1984; 21(7):589-603.

Müller-Eberhard HJ. The killer molecule of complement. J Invest Dermatol 1985; 85 1 Suppl:47s-52.

Morgan BP. Regulation of the complement membrane attack pathway. Crit Rev Immunol 1999; 19(3):173-98.

Zhou H, Li Q, Zou P, You Y. Endothelial cells: A novel key player in immunoregulation in acute graft-versus-host disease? Med Hypotheses 2009; 72(5):567-9.

Biedermann BC. Vascular endothelium and graft-versus-host disease. Best Pract Res Clin Haematol 2008; 21(2):129-38.

Patel ZS, Mikos AG. Angiogenesis with biomaterial-based drug- and cell-delivery systems. J Biomater Sci Polym Ed 2004; 15(6):701-26.

Kanczler JM, Oreffo RO. Osteogenesis and angiogenesis: The potential for engineering bone. Eur Cell Mater 2008; 15:100-14.

Naderi H, Matin MM, Bahrami AR. Review paper: Critical issues in tissue engineering: Biomaterials, cell sources, angiogenesis, and drug delivery systems. J Biomater Appl 2011; 26(4):383-417.

Binzen E, Rickert D, Kelch S, Fuhrmann R. Angiogenesis around new AB-polymer networks after one week of implantation in mice. Clin Hemorheol Microcirc 2003; 28(3):183-8.

Dhir S, Slatter M, Skinner R. Recent advances in the management of graft-versus-host disease. Arch Dis Child 2014; 99(12):1150-7.

Holtan SG, Pasquini M, Weisdorf DJ. Acute graft-versus-host disease: A bench-to-bedside update. Blood 2014; 124(3):363-73.

Jaglowski SM, Devine SM. Graft-versus-host disease: Why have we not made more progress? Curr Opin Hematol 2014; 21(2):141-7.

Guenther DA, Madsen JC. Advances in strategies for inducing central tolerance in organ allograft recipients. Pediatr Transplant 2005; 9(3):277-81.

Adams DH, Afford SC. Effector mechanisms of nonsuppurative destructive cholangitis in graft-versus-host disease and allograft rejection. Semin Liver Dis 2005; 25(3):281-97.

Biomaterials and host versus graft response: a short review


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Biomaterials and host versus graft response: a short review. Biomol Biomed [Internet]. 2016 Feb. 19 [cited 2024 Apr. 22];16(2):82-90. Available from: