Can NLR, PLR and LMR be used as prognostic indicators in patients with pulmonary embolism? Author’s reply on commentary

  • Nuri Kose Private Yuvelen Hospital https://orcid.org/0000-0001-8658-2598
  • Tarık Yıldırım Department of Cardiology, Faculty of Medicine, Balikesir University, Balikesir, Turkey
  • Fatih Akın Department of Cardiology, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, Turkey
  • Seda Elçim Yıldırım Department of Cardiology, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, Turkey
  • Ibrahim Altun Department of Cardiology, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, Turkey
Keywords: neutrophil-lymphocyte-ratio, platelet-lymphocyte-ratio, monocyte-lymphocyte-ratio, NLR, PLR, MLR

Abstract

We appreciate the comments made by Dr Bedel and colleagues. NLR, PLR and LMR are affected by various diseases such as oncological, collagen tissue, inflammatory, or severe renal/liver diseases [1]. Because of this, we have listed some of the above-mentioned disorders in the tables. Hematological diseases, collagen tissue disease, inflammatory diseases, congenital heart disease, or severe renal/liver disease were therefore excluded from the study. However, the presence of malignancy did not affect our results in regression analysis.
Platelets swell until 120 minutes in ethylene diamine tetra acetic (EDTA) and until 60 minutes in citrate [2]. Authors suggest that optimal measuring time should not exceed 120 minutes. The blood samples of the patients were taken within 1 hour after their emergency admission. All blood samples in our study were tested within 1 hour of collection [3]. We used EDTA for whole blood anticoagulation. The mean duration of symptoms prior to admission was 5.04 ± 6.9 days.
The drugs such as corticosteroids affect inflammatory parameters. Therefore, we excluded inflammatory diseases without emphasizing corticosteroids or other anti-inflammatory drugs.

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Can NLR, PLR and LMR be used as prognostic indicators in patients with pulmonary embolism? Author’s reply on commentary
Published
2020-11-06
How to Cite
1.
Kose N, Yıldırım T, Akın F, Elçim YıldırımS, AltunI. Can NLR, PLR and LMR be used as prognostic indicators in patients with pulmonary embolism? Author’s reply on commentary. Bosn J of Basic Med Sci [Internet]. 2020Nov.6 [cited 2020Dec.1];. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/5292
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