Recent advances of targeted therapy in relapsed/refractory acute myeloid leukemia

  • Jiale Ma Department of Hematology, Zhongda Hospital, School of Medicine, Southeast University, Institute of Hematology Southeast University, Nanjing, China; Department of Hematology, Xuzhou Central Hospital, Xuzhou, China https://orcid.org/0000-0002-5925-2996
  • Zheng Ge Department of Hematology, Zhongda Hospital, School of Medicine, Southeast University, Institute of Hematology Southeast University, Nanjing, China https://orcid.org/0000-0001-8028-1612
Keywords: Relapsed/refractory acute myeloid leukemia, targeted therapy, novel genetic mutations, immunotherapy

Abstract

Despite advances in the understanding of disease pathobiology, treatment for relapsed or refractory acute myeloid leukemia (R/R AML) remains challenging. The prognosis of R/R AML remains extremely poor despite chemotherapy and bone marrow transplants. Discoveries on recurrent and novel genetic mutations, such as FLT3-ITD and IDH1/IDH2, critical signaling pathways, and unique molecular markers expressed on the surface of leukemic cells have been under investigation for the management of R/R AML. Other than monoclonal antibodies, diabodies, and triabodies are new targeted therapies developed in recent years and will be the new direction of immunotherapy. Targeted agents combined intensive regimens can be viable options for salvage therapy and as bridges to allogeneic transplant. Future directions will focus on novel, efficient and targeted combinations, low-toxicity maintenance, and individualized precision strategies. Here, we review the major recent advances of targeted therapies in the treatment of R/R AML.

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Recent advances of targeted therapy in relapsed/refractory acute myeloid leukemia
Published
2021-01-27
How to Cite
1.
Ma J, Ge Z. Recent advances of targeted therapy in relapsed/refractory acute myeloid leukemia. Bosn J of Basic Med Sci [Internet]. 2021Jan.27 [cited 2021Jun.18];. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/5485
Section
Reviews

Funding data