Chronic mechanical irritation and oral squamous cell carcinoma: A systematic review and meta-analysis

Keywords: Chronic trauma, carcinogenesis, oral squamous cell carcinoma, risk factor

Abstract

The objective of the present article was to qualitatively and quantitatively review the association between chronic mechanical irritation and oral squamous cell carcinoma (OSCC). PubMed, SCOPUS, and Web of Science databases were searched using the keyword combinations “chronic trauma and oral squamous cell carcinoma; chronic irritation and oral squamous cell carcinoma; chronic irritation and oral cancer; and chronic trauma and oral cancer.” Duplicates and irrelevant articles were excluded after the title and abstract screening. The full texts of the remaining articles were assessed using selection criteria. A total of 375 (PubMed-126; SCOPUS-152; WOS-97) articles were screened, and 343 duplicates and irrelevant articles were excluded from the study. Only 9 of the remaining 32 articles met the selection criteria and were included in the qualitative analysis. Buccal mucosa and tongue, being highly prone to chronic irritation through the dental prosthesis, were the common sites for OSCC. Edentulous subjects with ill-fitting dentures were at a high risk of developing chronic irritation associated-OSCC. According to the Joanna Briggs Institute of risk assessment, eight of the nine included studies had a low risk of bias. The quantitative analysis showed a significant association (p < 0.00001) between the chronic oral mucosal irritation and OSCC with an overall risk ratio of 2.56 at a confidence interval of 1.96-3.35. Chronic oral mucosa irritation has a significant association with OSCC, and the nature of association could be that of a potential co-factor (dependent risk factor) rather than an independent risk factor.

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Author Biographies

Archana A. Gupta, Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pune, India

Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth

Supriya Kheur, Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pune, India

Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth

Saranya Varadarajan, Department of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital, Chennai, India

Department of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital

Sameena Parveen, Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia

Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University

Harisha Dewan, Department of Prosthetic Dental Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia

Department of Prosthetic Dental Sciences, College of Dentistry, Jazan University

Yaser Ali Alhazmi, Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia

Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University

Thirumal A. Raj , Department of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital, Chennai, India

Department of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital

Luca Testarelli, Department of Oral and Maxillofacial Sciences, Sapienza University, University of Rome, Rome, Italy

Department of Oral and Maxillofacial Sciences, Sapienza University, University of Rome

Chronic mechanical irritation and oral squamous cell carcinoma: A systematic review and meta-analysis
Published
2021-04-02
How to Cite
1.
Gupta AA, Kheur S, Varadarajan S, Parveen S, Dewan H, Alhazmi YA, Raj TA, Testarelli L, Patil S. Chronic mechanical irritation and oral squamous cell carcinoma: A systematic review and meta-analysis. Bosn J of Basic Med Sci [Internet]. 2021Apr.2 [cited 2021Sep.18];. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/5577
Section
Reviews