Chronic mechanical irritation and oral squamous cell carcinoma: A systematic review and meta-analysis

Authors

  • Archana A. Gupta Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pune, India https://orcid.org/0000-0002-5050-4288
  • Supriya Kheur Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pune, India https://orcid.org/0000-0002-2440-3547
  • Saranya Varadarajan Department of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital, Chennai, India https://orcid.org/0000-0002-7051-1143
  • Sameena Parveen Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia https://orcid.org/0000-0002-0800-4511
  • Harisha Dewan Department of Prosthetic Dental Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia https://orcid.org/0000-0002-2294-4710
  • Yaser Ali Alhazmi Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia
  • Thirumal A. Raj Department of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital, Chennai, India https://orcid.org/0000-0002-1079-1024
  • Luca Testarelli Department of Oral and Maxillofacial Sciences, Sapienza University, University of Rome, Rome, Italy https://orcid.org/0000-0003-3904-3000
  • Shankargouda Patil Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia https://orcid.org/0000-0001-7246-5497

DOI:

https://doi.org/10.17305/bjbms.2021.5577

Keywords:

Chronic trauma, carcinogenesis, oral squamous cell carcinoma, risk factor

Abstract

The objective of the present article was to qualitatively and quantitatively review the association between chronic mechanical irritation and oral squamous cell carcinoma (OSCC). PubMed, SCOPUS, and Web of Science databases were searched using the keyword combinations “chronic trauma and oral squamous cell carcinoma; chronic irritation and oral squamous cell carcinoma; chronic irritation and oral cancer; and chronic trauma and oral cancer.” Duplicates and irrelevant articles were excluded after the title and abstract screening. The full texts of the remaining articles were assessed using selection criteria. A total of 375 (PubMed-126; SCOPUS-152; WOS-97) articles were screened, and 343 duplicates and irrelevant articles were excluded from the study. Only 9 of the remaining 32 articles met the selection criteria and were included in the qualitative analysis. Buccal mucosa and tongue, being highly prone to chronic irritation through the dental prosthesis, were the common sites for OSCC. Edentulous subjects with ill-fitting dentures were at a high risk of developing chronic irritation associated-OSCC. According to the Joanna Briggs Institute of risk assessment, eight of the nine included studies had a low risk of bias. The quantitative analysis showed a significant association (p < 0.00001) between the chronic oral mucosal irritation and OSCC with an overall risk ratio of 2.56 at a confidence interval of 1.96-3.35. Chronic oral mucosa irritation has a significant association with OSCC, and the nature of association could be that of a potential co-factor (dependent risk factor) rather than an independent risk factor.

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Author Biographies

  • Archana A. Gupta, Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pune, India

    Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth

  • Supriya Kheur, Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pune, India

    Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth

  • Saranya Varadarajan, Department of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital, Chennai, India

    Department of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital

  • Sameena Parveen, Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia

    Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University

  • Harisha Dewan, Department of Prosthetic Dental Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia

    Department of Prosthetic Dental Sciences, College of Dentistry, Jazan University

  • Yaser Ali Alhazmi, Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia

    Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University

  • Thirumal A. Raj , Department of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital, Chennai, India

    Department of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital

  • Luca Testarelli, Department of Oral and Maxillofacial Sciences, Sapienza University, University of Rome, Rome, Italy

    Department of Oral and Maxillofacial Sciences, Sapienza University, University of Rome

Chronic mechanical irritation and oral squamous cell carcinoma: A systematic review and meta-analysis

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Published

01-12-2021

How to Cite

1.
Chronic mechanical irritation and oral squamous cell carcinoma: A systematic review and meta-analysis. Biomol Biomed [Internet]. 2021 Dec. 1 [cited 2024 Jun. 14];21(6):647-58. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/5577