Audiological and vestibular evaluations in vitiligo patients

Keywords: VEMPs, vitiligo, vestibular system, hearing loss, otic melanocytes


The aim of this paper was to investigate audiological abnormalities and potential vestibular injury in a sample of vitiligo subjects. Thirty-five patients with non-segmental vitiligo (NSV) were enrolled in the study. They underwent pure tonal audiometry (PTA), vestibular Fitzgerald-Hallpike caloric test, C-VEM, and O-VEMP testing.  The χ2 test and multiple regression analysis were performed. At PTA, 69% of patients presented with bilateral hearing loss, 8% monaural hearing loss, and 23% normal values. Bilateral caloric stimulations were performed and demonstrated that 14% of patients had a monolateral and 9% had a bilateral pathological response. VEMPs analysis showed that  20% of patients had no O-VEMPs response and 3% had no C-VEMPs response. Comparison between the normal values of healthy subjects and NSV patients showed an alteration of VEMPs in 44%. Multiple regression showed no statistical differences. We propose a specific diagnostic protocol employing PTA, bithermal caloric tests, C-VEMP, and O-VEMP testing to evaluate audio-vestibular damage. Our data were concordant with the anatomic-physiological melanocytic distribution and their possible degeneration linked with NSV. 


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Audiological and vestibular evaluations in vitiligo patients
How to Cite
Manno A, Pace A, Iannella G, Rossetti V, Polimeni R, Milani A, Cocuzza S, Maniaci A, Magliulo G. Audiological and vestibular evaluations in vitiligo patients. Bosn J of Basic Med Sci [Internet]. 2021Aug.9 [cited 2022Jan.17];. Available from:
Translational and Clinical Research