The prognostic significance of different proportion of signet-ring cells of colorectal carcinoma

  • Wei Chen Department of Gynecology, The Affiliated Hospital of Putian University, Putian, China
  • Huajun Cai Department of Colorectal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China
  • Kui Chen Department of General Surgery, The First Hospital of Fuzhou City Affiliated Fujian Medical University, Fuzhou, China
  • Xing Liu Department of Colorectal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China
  • Weizhong Jiang Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, China
  • Shoufeng Li Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, China
  • Yiyi Zhang Department of Colorectal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China
  • Zhifen Chen Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, China https://orcid.org/0000-0001-7199-7061
  • Guoxian Guan Department of Colorectal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China
Keywords: Rectal cancer, signet-ring cell carcinoma, prognosis, nomogram

Abstract

While the prognosis of patients with partial SRCC (PSRCC) has been rarely reported, colorectal signet-ring cell carcinoma (SRCC) has been associated with poor prognosis. The aim of this study was to analyze the prognosis of patients with different SRCC composition and establish a prediction model. A total of 91 patients with SRC component were included in the study. These patients were divided into two groups: SRCC group (SRC composition > 50%; n=41) and partial SRCC (PSRCC) group (SRC composition ≤ 50%; n=50). COX regression model was used to identify independent prognostic factors for overall survival (OS). A predictive nomogram was established and compared with the 7th AJCC staging system. After a median follow-up of 16 months, no significant difference in OS was observed in either group. Preoperative carcinoembryonic antigen (CEA) level, pN stage, M stage, preoperative ileus, and adjuvant chemotherapy were independent prognostic risk factors for OS (p<0.05). A nomogram for predicting the overall survival of colorectal SRCC was established with a C-index of 0.800, and it showed better performance than that of the 7th AJCC staging system (p<0.001). In summary, the ratio of SRC component was not an independent prognostic factor of the OS. Those patients with less than 50% of SRC component should be given the same clinical attention. A predictive nomogram for survival based on five independent prognostic factors was developed and showed better performance than the 7th AJCC staging system. This resulted to be helpful for individualized prognosis prediction and risk assessment.

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The prognostic significance of different proportion of signet-ring cells of colorectal carcinoma
Published
2021-05-29
How to Cite
1.
Chen W, Cai H, Chen K, Liu X, Jiang W, Li S, Zhang Y, Chen Z, Guan G. The prognostic significance of different proportion of signet-ring cells of colorectal carcinoma. Bosn J of Basic Med Sci [Internet]. 2021May29 [cited 2021Sep.17];. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/5856
Section
Translational and Clinical Research