Perineural spread in head and neck malignancies: imaging findings - an updated literature review

Keywords: Head and neck tumors, perineural invasion, cranial nerves, neuroanatomy imaging methods

Abstract

Perineural spread (PNS) represents the tumor’s ability to disseminate along nerves. The aim of this article is to review the relevant literature about the PNS in head and neck tumors (HN). The important information for imaging analysis is summarized in a diagnostic flow-chart. The pathogenesis, clinical signs, prognostic importance, and technical considerations for computer tomography and magnetic resonance imaging are briefly discussed. The anatomical pathways of the cranial nerves (CNs) and the main check-points are synthesized. Most commonly affected nerves are the trigeminal and facial, although any of the CNs may be involved. The described imaging features represent important clues for an optimal differential diagnosis. PNS worsens the prognosis and significantly changes the treatment, thus radiologists should be aware of this entity and be able to find it on imaging in the appropriate clinical context.

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Perineural spread in head and neck malignancies: imaging findings - an updated literature review
Published
2021-06-29
How to Cite
1.
Medvedev O, Hedesiu M, Ciurea A, Lenghel M, Rotar H, Dinu C, Roman R, Termure D, Csutak C. Perineural spread in head and neck malignancies: imaging findings - an updated literature review. Bosn J of Basic Med Sci [Internet]. 2021Jun.29 [cited 2021Sep.29];. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/5897
Section
Reviews