Poorly differentiated clusters and tumor budding are important prognostic factors in colorectal carcinomas

  • Aura Jurescu Department of Microscopic Morphology - Morphopathology, ANAPATMOL Research Center, “Victor Babeş” University of Medicine and Pharmacy, Timișoara https://orcid.org/0000-0002-0898-795X
  • Alis Dema Department of Microscopic Morphology - Morphopathology, ANAPATMOL Research Center, “Victor Babeş” University of Medicine and Pharmacy, Timișoara, Romania; 2 Department of Pathology, “Pius Brînzeu” County Clinical Emergency Hospital, Timişoara, Romania https://orcid.org/0000-0003-0767-2718
  • Adrian Văduva Department of Microscopic Morphology - Morphopathology, ANAPATMOL Research Center, “Victor Babeş” University of Medicine and Pharmacy, Timișoara, Romania; 2Department of Pathology, “Pius Brînzeu” County Clinical Emergency Hospital, Timişoara, Romania https://orcid.org/0000-0001-9261-5309
  • Adelina Gheju Department of Microscopic Morphology - Morphopathology, ANAPATMOL Research Center, “Victor Babeş” University of Medicine and Pharmacy, Timișoara, Romania https://orcid.org/0000-0002-0060-1805
  • Octavia Vița 1 Department of Microscopic Morphology - Morphopathology, ANAPATMOL Research Center, “Victor Babeş” University of Medicine and Pharmacy, Timișoara, Romania https://orcid.org/0000-0002-8259-9437
  • Robert Barna Department of Microscopic Morphology - Morphopathology, ANAPATMOL Research Center, “Victor Babeş” University of Medicine and Pharmacy, Timișoara, Romania; 2 Department of Pathology, “Pius Brînzeu” County Clinical Emergency Hospital, Timişoara, Romania https://orcid.org/0000-0003-4634-969X
  • Codruța Lăzureanu Department of Microscopic Morphology - Morphopathology, ANAPATMOL Research Center, “Victor Babeş” University of Medicine and Pharmacy, Timișoara, Romania; 2 Department of Pathology, “Pius Brînzeu” County Clinical Emergency Hospital, Timişoara, Romania https://orcid.org/0000-0002-2291-4917
  • Marioara Cornianu Department of Microscopic Morphology - Morphopathology, ANAPATMOL Research Center, “Victor Babeş” University of Medicine and Pharmacy, Timișoara, Romania; 2 Department of Pathology, “Pius Brînzeu” County Clinical Emergency Hospital, Timişoara, Romania
  • Sorina Tăban Department of Microscopic Morphology - Morphopathology, ANAPATMOL Research Center, “Victor Babeş” University of Medicine and Pharmacy, Timișoara, Romania; 2 Department of Pathology, “Pius Brînzeu” County Clinical Emergency Hospital, Timişoara, Romania
  • Ciprian Duță Department of Surgery II, “Victor Babeş” University of Medicine and Pharmacy, Timișoara, Romania; 4 Department of Surgery II, “Pius Brînzeu” County Clinical Emergency Hospital, Timişoara, Romania
  • Stelian Pantea Department of Surgery II, “Victor Babeş” University of Medicine and Pharmacy, Timișoara, Romania; 5 Department of Surgery III, “Pius Brînzeu” County Clinical Emergency Hospital, Timişoara, Romania https://orcid.org/0000-0002-6048-6909
Keywords: Colorectal carcinomas, tumor budding, poorly differentiated clusters, grading system, prognostic factors

Abstract

The aim of our study was to assess the prognostic value of the two new grading systems based on the quantification of tumor budding - TB (GBd) and poorly differentiated clusters - PDCs (PDCs-G) in colorectal carcinomas (CRC). We performed a retrospective study on 71 CRC patients who underwent surgery at the Emergency County Hospital, Timișoara. CRC cases were classified based on haematoxylin-eosin slides, using the conventional grading system, GBd and PDCs-G, respectively. We used two-tier and three-tier grading schemes for each system. Subsequently,  we evaluated  associations with other prognostic factors in CRC. Based on the three-tier GBd (GBd-3t)  most cases (34/69, 49.27%) were classified as G3Bd-3t, while based on the conventional grading system, the majority of the cases (55/69, 79.71%) were considered G2. On the other hand, based on the three-tier PDCs-G system (PDCs-G-3t), most cases (31/69, 44.93%) were PDCs-G2-3t. We also noted a more significant association of GBd-3t with other prognostic parameters analyzed, as compared to the conventional grading system. Nodal status, tumor stage, and lymphovascular invasion were strongly correlated with GBd-3t (p=0.0001). Furthermore, we noted that PDCs-G-3t correlated more significantly than the conventional grading system with nodal status (p<0.0001), tumor stage (p=0.0003), lymphovascular invasion (p<0.0001), perineural invasion (p=0.005) and the tumor border configuration (p<0.0001). 

High GBd and PDCs-G grades correlate directly with other negative prognostic factors in CRC.Thus, these new parameters/classification methods could be used as additional tools for risk stratification in patients with CRC.



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Published
2021-09-03
How to Cite
1.
Jurescu A, Dema A, Văduva A, Gheju A, Vița O, Barna R, Lăzureanu C, Cornianu M, Tăban S, Duță C, Pantea S. Poorly differentiated clusters and tumor budding are important prognostic factors in colorectal carcinomas . Bosn J of Basic Med Sci [Internet]. 2021Sep.3 [cited 2021Sep.29];. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/6110
Section
Pathology