Genetic predictors of the response to the treatment of hepatitis C virus infection

Pavlina Dzekova-Vidimliski; Igor G. Nikolov; Nadica Matevska-Geshkovska; Yana Boyanova; Nina Nikolova; Grigore Romanciuc; Dan Dumitrascu; Viktorija Caloska-Ivanova; Nenad Joksimovic; Krasimir Antonov; Lyudmila Mateva; Lionel Rostaing; Aleksandar Dimovski; Aleksandar Sikole

doi:10.17305/bjbms.2015.632

Authors

Pavlina Dzekova-Vidimliski University Hospital of Nephrology, Skopje, R. Macedonia
Igor G. Nikolov University Hospital of Nephrology, Skopje, R. Macedonia
Nadica Matevska-Geshkovska Faculty of Farmacy, University “Ss Cyril and Methodius”, Skopje, R. Macedonia
Yana Boyanova Clinic of Gastroenterology, St Ivan Rilski University Hospital, Sofia, R.Bulgaria
Nina Nikolova Clinic of Gastroenterology, St Ivan Rilski University Hospital, Sofia, R.Bulgaria
Grigore Romanciuc Université de Medicine "Nicolae Testemitanu" Chisinau, Moldova
Dan Dumitrascu University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, Romania
Viktorija Caloska-Ivanova University Hospital of Gastroenterohepatology, Skopje, R. Macedonia
Nenad Joksimovic University Hospital of Gastroenterohepatology, Skopje, R. Macedonia
Krasimir Antonov Clinic of Gastroenterology, St Ivan Rilski University Hospital, Sofia, R.Bulgaria
Lyudmila Mateva Clinic of Gastroenterology, St Ivan Rilski University Hospital, Sofia, R.Bulgaria
Lionel Rostaing Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, Toulouse, France
Aleksandar Dimovski Faculty of Farmacy, University “Ss Cyril and Methodius”, Skopje, R. Macedonia
Aleksandar Sikole University Hospital of Nephrology, Skopje, R. Macedonia

DOI:

https://doi.org/10.17305/bjbms.2015.632

Keywords:

single nucleotide polymorphisms, interferon-lambda protein, hepatitis C chronic, treatment

Abstract

The genome-wide association studies have identified a strong association between interleukin 28B (IL28B) gene polymorphisms and the response to treatment in patients with hepatitis C virus (HCV) infection. The aim of the study was to evaluate the association between three most widely studied IL28B gene polymorphisms and the response to antiviral treatment of chronic hepatitis C. We performed the genotyping of the three IL28B gene polymorphisms: rs12979860, rs8099917, and rs12980275 in 72 Caucasian patients with chronic hepatitis C, previously treated with the combination therapy of pegylated interferon alpha (PEGIFN α) and ribavirin (RBV). The patients included in the study had finished the treatment regimen at least 6 months before enrolling in the study. We used the sustained viral response (SVR) for the evaluation of the effectiveness of the antiviral treatment, and it was tested with an assay with a sensitivity of 20 IU/mL. An SVR was achieved in 59.7% (43/72) of the treated patients. The three IL28B gene polymorphisms (CC genotype of rs12979860, TT genotype of rs8099917, and AA genotype of rs12980275) were associated with the SVR (p = 0.029, p = 0.016, and p = 0.028, respectively) in the study patients with chronic hepatitis C treated with the combination therapy of PEGIFN α and RBV. The association of IL28B gene polymorphisms with the treatment response points to the possibility of personalized medicine for the treatment of HCV infection.

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