Clinical features and major bleeding predictors for 161 fatal cases of COVID-19: A retrospective observational study

  • Gokhan Alici Okmeydani Training and Research Hospital, Department of Cardiology, Istanbul, Turkey https://orcid.org/0000-0002-4589-7566
  • Hasan Ali Barman Istanbul University – Cerrahpaşa, Institute of Cardiology, Department of Cardiology, Istanbul, Turkey
  • Ramazan Asoglu Adiyaman Training ve Research Hospital, Department of Cardiology, Adiyaman, Turkey https://orcid.org/0000-0002-4777-1166
  • Adem Atici Istanbul Medeniyet University, Faculty of Medicine, Goztepe Training and Research Hospital, Department of Cardiology, Istanbul, Turkey
  • Atike Nazli Akciger University of Health Sciences, Okmeydani Training and Research Hospital, Department of Cardiology, Istanbul, Turkey
  • Omer Sit University of Health Sciences, Okmeydani Training and Research Hospital, Department of Cardiology, Istanbul, Turkey
  • Omer Dogan Istanbul University – Cerrahpaşa, Institute of Cardiology, Department of Cardiology, Istanbul, Turkey https://orcid.org/0000-0003-2279-6110
  • Yucel Yavuz University of Health Sciences, Okmeydani Training and Research Hospital, Department of Anesthesiology and Intensive Care, Istanbul, Turkey
  • Songul Borahan University of Health Sciences, Okmeydani Training and Research Hospital, Department of Anesthesiology and Intensive Care, Istanbul, Turkey
  • Omer Genc Agri Training ve Research Hospital, Department of Cardiology, Agri, Turkey https://orcid.org/0000-0002-9097-5391
  • Baris Gungor University of Health Sciences, Dr. Siyami Ersek Training and Research Hospital, Department of Cardiology, Istanbul, Turkey https://orcid.org/0000-0002-8883-117X
Keywords: Major bleeding, COVID-19, mortality, acute respiratory distress syndrome, cardiac injury

Abstract

The aim of this study was to investigate the patient characteristics and laboratory parameters for COVID-19 non-survivors as well as to find risk factors for major bleeding complications. For this retrospective study, the data of patients who died with COVID-19 in our intensive care unit were collected in the period of March 20 - April 30, 2020. D-dimer, platelet count, C-reactive protein (CRP), troponin, and international normalized ratio (INR) levels were recorded on the 1st, 5th, and 10th days of hospitalization in order to investigate the possible correlation of laboratory parameter changes with in-hospital events. A total of 161 non-survivors patients with COVID-19 were included in the study.  The median age was 69.8±10.9 years, and 95 (59%) of the population were male. Lung-related complications were the most common in-hospital complications. Patients with COVID-19 had in-hospital complications such as major bleeding (39%), hemoptysis (14%), disseminated intravascular coagulation (13%), liver failure (21%), ARDS (85%), acute kidney injury (40%), and myocardial injury (70%). A multiple logistics regression analysis determined that age, hypertension, diabetes mellitus, use of acetylsalicylic acid (ASA) or low molecular weight heparin (LMWH), hemoglobin, D-dimer, INR, and acute kidney injury were independent predictors of major bleeding. Our results showed that a high proportion of COVID-19 non-survivors suffered from major bleeding complications.

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Clinical features and major bleeding predictors for 161fatal cases of  COVID-19: A retrospective observational study
Published
2021-11-22
How to Cite
1.
Gokhan Alici, Hasan Ali Barman, Ramazan Asoglu, Atici A, Akciger AN, Sit O, Dogan O, Yucel Yavuz, Songul Borahan, Omer Genc, Baris Gungor. Clinical features and major bleeding predictors for 161 fatal cases of COVID-19: A retrospective observational study. Bosn J of Basic Med Sci [Internet]. 2021Nov.22 [cited 2021Dec.6];. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/6577
Section
Translational and Clinical Research