Evaluation of qualitative and quantitative taste alterations in COVID-19

Authors

  • Angela Pia Cazzolla Department of Clinical and Experimental Medicine, Università degli Studi di Foggia, Foggia, Italy https://orcid.org/0000-0003-0842-7351
  • Roberto Lovero Clinical Pathology Unit, AOU Policlinico Consorziale di Bari - Ospedale Giovanni XXIII, Bari, Italy https://orcid.org/0000-0001-7580-5733
  • Francesca Spirito Department of Clinical and Experimental Medicine, Università degli Studi di Foggia, Foggia, Italy https://orcid.org/0000-0002-8364-2425
  • Michele Di Cosola Department of Clinical and Experimental Medicine, Università degli Studi di Foggia, Foggia, Italy
  • Luigi Santacroce Ionian Department (DJSGEM), Microbiology and Virology Lab, Università Degli Studi di Bari, Bari, Italy https://orcid.org/0000-0001-5671-8124
  • Eleonora Lo Muzio Department of Translational Medicine and for Romagna, School of Orthodontics, University of Ferrara, Ferrara, Italy https://orcid.org/0000-0002-3588-1034
  • Domenico Ciavarella Department of Clinical and Experimental Medicine, Università degli Studi di Foggia, Foggia, Italy https://orcid.org/0000-0003-3114-6048
  • Mario Dioguardi Department of Basic Medical Sciences, Neurosciences and Sensory Organs, "Aldo Moro" University of Bari, Bari, Italy
  • Vito Crincoli Department of Basic Medical Sciences, Neurosciences and Sensory Organs, "Aldo Moro" University of Bari, Bari, Italy
  • Maria Pepe Transfusional Medicine Unit, University-Policlinico, Bari, Italy https://orcid.org/0000-0003-1127-8967
  • Lucia Varraso Clinical Pathology Unit, AOU Policlinico Consorziale di Bari - Ospedale Giovanni XXIII, Bari, Italy https://orcid.org/0000-0002-8292-923X
  • Renato Contino Clinical Pathology Unit, AOU Policlinico Consorziale di Bari - Ospedale Giovanni XXIII, Bari, Italy https://orcid.org/0000-0001-7538-3219
  • Francesca Di Serio Clinical Pathology Unit, AOU Policlinico Consorziale di Bari - Ospedale Giovanni XXIII, Bari, Italy https://orcid.org/0000-0001-6089-1165
  • Lorenzo Lo Muzio Department of Clinical and Experimental Medicine, Università degli Studi di Foggia, Foggia, Italy; Consorzio Interuniversitario Nazionale per la Bio-Oncologia (C.I.N.B.O), Chieti, Italy https://orcid.org/0000-0003-4633-4893

DOI:

https://doi.org/10.17305/bjbms.2022.6973

Keywords:

COVID-19, taste dysfunction, dysgeusia

Abstract

Taste dysfunctions occur in a large proportion of COVID-19 patients. This observational study compared interleukin-6 (IL-6) levels in mild and moderate COVID-19 patients with the type (quantitative or qualitative) of taste disorders. The 208 COVID-19 patients (118 men and 90 women) showing only taste dysfunctions as prodromic symptoms were classified as mild and moderate patients. The evaluation of the taste disorder was carried out using a survey. The IL-6 levels were measured with a chemiluminescence assay. Statistical analysis was performed using the Wilcoxon rank, Welch’s, and Mann-Whitney tests (p <0.05). The results showed that there were no statistically significant differences in the perception of sour and salty, nor in the presence of dysgeusia and phantogeusia in moderate versus mild patients (p>0.05). However, there were statistically significant differences in the perception of umami, bitter, sweet, and the presence of parageusia in moderate versus mild patients (p<0.05). There was an impairment of multiple tastes up to ageusia in patients with high IL-6 levels. The results showed that dysfunctions in the perception of sweet, bitter, umami, and the presence of parageusia can be considered as signs of more severe forms of COVID-19.

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Evaluation of qualitative and quantitative taste alterations in COVID-19

Published

2022-07-07

How to Cite

1.
Cazzolla AP, Lovero R, Spirito F, Di Cosola M, Santacroce L, Lo Muzio E, Ciavarella D, Dioguardi M, Crincoli V, Pepe M, Varraso L, Contino R, Di Serio F, Lo Muzio L. Evaluation of qualitative and quantitative taste alterations in COVID-19. Bosn J of Basic Med Sci [Internet]. 2022Jul.7 [cited 2022Aug.18];. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/6973

Issue

Section

New and Emerging Medical Entities