Predictors of COVID-19 severity among pregnant patients

Authors

  • Marcin Januszewski Department of Obstetrics and Gynecology, Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland https://orcid.org/0000-0001-5098-0156
  • Laura Ziuzia-Januszewska Department of Otolaryngology, Central Clinical Hospital of the Ministry of Interior and Administration, Warsaw, Poland https://orcid.org/0000-0002-8839-6489
  • Alicja A. Jakimiuk Department of Plastic Surgery, Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland https://orcid.org/0000-0003-0216-8600
  • Tomasz Oleksik Department of Obstetrics and Gynecology, Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland https://orcid.org/0000-0002-3904-097X
  • Marek Pokulniewicz Department of Obstetrics and Gynecology, Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland
  • Waldemar Wierzba Department of Obstetrics and Gynecology, Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland; University of Humanities and Economics in Lodz, Satellite Campus in Warsaw, Warsaw, Poland https://orcid.org/0000-0002-8134-2955
  • Krzysztof Kozlowski Department of Constitutional Law, Jagiellonian University in Krakow, Krakow, Poland https://orcid.org/0000-0002-7439-7165
  • Artur J. Jakimiuk Department of Obstetrics and Gynecology, Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland; Center for Reproductive Health, Institute of Mother and Child, Warsaw, Poland https://orcid.org/0000-0002-7373-7690

DOI:

https://doi.org/10.17305/bjbms.2022.7181

Keywords:

COVID-19, pregnancy, SARS-CoV-2, clinical course, predictors, disease severity, lymphocytopenia, hypocalcemia, low total protein, inflammation biomarkers

Abstract

Coronavirus disease 2019 (COVID-19) was declared a pandemic and has spread around the globe, unsparingly affecting vulnerable populations. Effective prevention measures for pregnant women, who are particularly affected, include early identification of those patients at risk of developing in-hospital complications, and the continuous improvement of maternal-fetal treatment strategies to ensure the efficient use of health resources. The objective of our retrospective study was to determine which patient biomarkers on hospital admission correlate with disease severity as measured by disease course classification, the need for oxygen supplementation and higher demand for oxygen, the need for mechanical ventilation, intensive care unit admission, and length of hospital stay. Analysis of 52 PCR SARS-CoV-2 positive pregnant women revealed that the median date of hospital admission was the 30th gestational week, with dyspnoea, cough, and fever as the leading symptoms. The presence of diabetes and hypertension predisposed pregnant women to the severe course of illness. Lung involvement shown by CT scans on admission correlated with the greater clinical severity. The main laboratory predictors of disease progression were lymphocytopenia, hypocalcemia, low total cholesterol, low total protein levels, and high serum levels of C-reactive protein, ferritin, interleukin-6, glucose, lactate dehydrogenase, procalcitonin, and troponin I. Further research with a larger cohort of pregnant women is needed to determine the utility of these results for everyday practice.

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Predictors of COVID-19 severity among pregnant patients

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Published

2022-06-05

How to Cite

1.
Januszewski M, Ziuzia-Januszewska L, Jakimiuk AA, Oleksik T, Pokulniewicz M, Wierzba W, Kozlowski K, Jakimiuk AJ. Predictors of COVID-19 severity among pregnant patients. Bosn J of Basic Med Sci [Internet]. 2022Jun.5 [cited 2022Aug.18];. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/7181

Issue

Section

New and Emerging Medical Entities