Development and validation of radiomics machine learning model based on contrast-enhanced computed tomography to predict axillary lymph node metastasis in breast cancer

Authors

  • Jieqiu Zhang School of Public Health, Southwest Medical University, Luzhou, China https://orcid.org/0000-0002-5554-5329
  • Gaofei Cao School of Medical Information and Engineering, Southwest Medical University, Luzhou, China https://orcid.org/0000-0002-6815-0051
  • Haowen Pang Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, China
  • Jin Li School of Medical Information and Engineering, Southwest Medical University, Luzhou, China https://orcid.org/0000-0001-8947-8892
  • Xiaopeng Yao School of Medical Information and Engineering, Southwest Medical University, Luzhou, China; Central Nervous System Drug Key Laboratory of Sichuan Province, Southwest Medical University, Luzhou, China https://orcid.org/0000-0003-1586-2079

DOI:

https://doi.org/10.17305/bjbms.2022.7853

Keywords:

breast cancer, axillary lymph node metastasis, radiomics, machine learning, contrast-enhanced computed tomography, nomogram

Abstract

Preoperative identification of axillary lymph node metastasis can play an important role in treatment selection strategy and prognosis evaluation. This study aimed to establish a clinical nomogram based on lymph node images to predict lymph node metastasis in breast cancer patients. A total of 193 patients with non-specific invasive breast cancer were divided into training (n = 135) and validation set (n = 58). Radiomics features were extracted from lymph node images instead of tumor region, and the least absolute shrinkage and selection operator logistic algorithm was used to select the extracted features and generate radiomics score. Then, the important clinical factors and radiomics score were integrated into a nomogram. A receiver operating characteristic curve was used to evaluate the nomogram, and the clinical benefit of using the nomogram was evaluated by decision curve analysis. We found that clinical N stage and radiomics score were independent clinical predictors. Besides, the nomogram accurately predicted axillary lymph node metastasis, yielding an area under the receiver operating characteristic curve of 0.95 (95% confidence interval 0.93-0.98) in the validation set, indicating satisfactory calibration. Decision curve analysis confirmed that the nomogram had higher clinical utility than clinical N stage or radiomics score alone. Overall, the nomogram based on radiomics features and clinical factors can help radiologists to predict axillary lymph node metastasis preoperatively and provide valuable information for individual treatment.

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Development and validation of radiomics machine learning model based on contrast-enhanced computed tomography to predict axillary lymph node metastasis in breast cancer

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Published

16-03-2023

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Section

Translational and Clinical Research

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How to Cite

1.
Development and validation of radiomics machine learning model based on contrast-enhanced computed tomography to predict axillary lymph node metastasis in breast cancer. Biomol Biomed [Internet]. 2023 Mar. 16 [cited 2024 Jun. 22];23(2):317–326. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/7853